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    Mnat9 microtubule-associated Nat9 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43726, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Mnat9provided by FlyBase
    Official Full Name
    microtubule-associated Nat9provided by FlyBase
    Primary source
    FLYBASE:FBgn0039859
    Locus tag
    Dmel_CG11539
    See related
    AllianceGenome:FB:FBgn0039859
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11539; Dmel\CG11539; NAT9
    Summary
    Enables microtubule binding activity and tubulin N-terminal N-acetyltransferase activity. Involved in negative regulation of intracellular signal transduction and regulation of microtubule cytoskeleton organization. Orthologous to human NAT9 (N-acetyltransferase 9). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Mnat9 in Genome Data Viewer
    Location:
    100D1-100D1; 3-102 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (31615284..31616160, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (27441006..27441882, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Ribosomal protein L6 Neighboring gene Cyclin G Neighboring gene Medea Neighboring gene uncharacterized protein Neighboring gene partner of drosha Neighboring gene kekkon 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Targeted recombination of homologous chromosomes using CRISPR-Cas9. Son W, et al. FEBS Open Bio, 2023 Sep. PMID 37462508, Free PMC Article
    2. Modulation of Hippo signaling by Mnat9 N-acetyltransferase for normal growth and tumorigenesis in Drosophila. Mok JW, et al. Cell Death Dis, 2022 Feb 2. PMID 35110540, Free PMC Article
    3. N-Acetyltransferase 9 ameliorates Aβ42-mediated neurodegeneration in the Drosophila eye. Deshpande P, et al. Cell Death Dis, 2023 Jul 28. PMID 37507384, Free PMC Article
    4. Novel function of N-acetyltransferase for microtubule stability and JNK signaling in Drosophila organ development. Mok JW, et al. Proc Natl Acad Sci U S A, 2021 Jan 26. PMID 33479178, Free PMC Article
    5. Global and specific responses of the histone acetylome to systematic perturbation. Feller C, et al. Mol Cell, 2015 Feb 5. PMID 25578876

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-Acetyltransferase 9 ameliorates Abeta42-mediated neurodegeneration in the Drosophila eye.
      Title: N-Acetyltransferase 9 ameliorates Aβ42-mediated neurodegeneration in the Drosophila eye.
    2. Modulation of Hippo signaling by Mnat9 N-acetyltransferase for normal growth and tumorigenesis in Drosophila.
      Title: Modulation of Hippo signaling by Mnat9 N-acetyltransferase for normal growth and tumorigenesis in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables N-acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tubulin N-terminal N-acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of JNK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of hippo signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of microtubule depolymerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of microtubule polymerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of mitotic spindle assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    microtubule-associated Nat9
    Names
    CG11539-PA
    CG11539-PB
    Mnat9-PA
    Mnat9-PB
    NP_001263148.1
    NP_651877.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      31615284..31616160 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001276219.1 → NP_001263148.1  microtubule-associated Nat9, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263148.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V9V9
      UniProtKB/TrEMBL
      A0A0B4KHX9
      Conserved Domains (2) summary
      pfam00583
      Location:76 → 160
      Acetyltransf_1; Acetyltransferase (GNAT) family
      pfam13302
      Location:13 → 158
      Acetyltransf_3; Acetyltransferase (GNAT) domain

    2. NM_143620.2 → NP_651877.1  microtubule-associated Nat9, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651877.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V9V9
      UniProtKB/TrEMBL
      A0A0B4KHX9
      Related
      FBpp0085227
      Conserved Domains (2) summary
      pfam00583
      Location:76 → 160
      Acetyltransf_1; Acetyltransferase (GNAT) family
      pfam13302
      Location:13 → 158
      Acetyltransf_3; Acetyltransferase (GNAT) domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KHX9 A0A0B4KHX9
    Q9V9V9.1 Q9V9V9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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