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    Afti Aftiphilin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41744, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Aftiprovided by FlyBase
    Official Full Name
    Aftiphilinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038223
    Locus tag
    Dmel_CG8538
    See related
    AllianceGenome:FB:FBgn0038223
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8538; dAfti; Dmel\CG8538
    Summary
    Enables AP-1 adaptor complex binding activity and clathrin adaptor activity. Involved in compound eye photoreceptor development and intracellular transport. Located in trans-Golgi network membrane. Orthologous to human AFTPH (aftiphilin). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See Afti in Genome Data Viewer
    Location:
    88B3-88B4; 3-55 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (14320191..14326689, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (10145913..10152411, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Corazonin Neighboring gene SET domain containing 8 Neighboring gene ATP synthase, subunit E Neighboring gene spindle B Neighboring gene NK7.1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. AP-1 clathrin adaptor and CG8538/Aftiphilin are involved in Notch signaling during eye development in Drosophila melanogaster. Kametaka S, et al. J Cell Sci, 2012 Feb 1. PMID 22389401
    2. Prevalence of off-target effects in Drosophila RNA interference screens. Ma Y, et al. Nature, 2006 Sep 21. PMID 16964239
    3. A genome-wide CRISPR screen identifies DPM1 as a modifier of DPAGT1 deficiency and ER stress. Dalton HM, et al. PLoS Genet, 2022 Sep. PMID 36166480, Free PMC Article
    4. Ribosome profiling reveals pervasive and regulated stop codon readthrough in Drosophila melanogaster. Dunn JG, et al. Elife, 2013 Dec 3. PMID 24302569, Free PMC Article
    5. Identification of genes that promote or inhibit olfactory memory formation in Drosophila. Walkinshaw E, et al. Genetics, 2015 Apr. PMID 25644700, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CG8538p, an uncharacterized Drosophila protein, shares significant structural and functional characteristics with Aftiphilin, a mammalian AP-1 accessory protein.
      Title: AP-1 clathrin adaptor and CG8538/Aftiphilin are involved in Notch signaling during eye development in Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables AP-1 adaptor complex binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables clathrin adaptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables clathrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables clathrin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in compound eye development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in compound eye photoreceptor development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of AP-1 adaptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in trans-Golgi network membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in trans-Golgi network membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    aftiphilin
    Names
    Afti-PB
    Afti-PC
    Afti-PD
    Afti-PE
    CG8538-PB
    CG8538-PC
    CG8538-PD
    CG8538-PE
    dAftiphilin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      14320191..14326689 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001260173.2 → NP_001247102.1  aftiphilin, isoform D [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86P42, Q9VFK5
      Conserved Domains (1) summary
      pfam15045
      Location:459 → 516
      Clathrin_bdg; Clathrin-binding box of Aftiphilin, vesicle trafficking

    2. NM_001260172.2 → NP_001247101.1  aftiphilin, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86P42, Q9VFK5
      Conserved Domains (1) summary
      pfam15045
      Location:459 → 516
      Clathrin_bdg; Clathrin-binding box of Aftiphilin, vesicle trafficking

    3. NM_001370051.1 → NP_001356916.1  aftiphilin, isoform E [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4D6K2J4
      Conserved Domains (1) summary
      pfam15045
      Location:462 → 516
      Clathrin_bdg; Clathrin-binding box of Aftiphilin, vesicle trafficking

    4. NM_142098.4 → NP_650355.2  aftiphilin, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86P42, Q9VFK5
      Conserved Domains (1) summary
      pfam15045
      Location:459 → 516
      Clathrin_bdg; Clathrin-binding box of Aftiphilin, vesicle trafficking
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A4D6K2J4 A0A4D6K2J4
    Q9VFK5 Q9VFK5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
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