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    Trmt112 tRNA methyltransferase subunit 11-2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40343, updated on 9-Dec-2024

    Summary

    Official Symbol
    Trmt112provided by FlyBase
    Official Full Name
    tRNA methyltransferase subunit 11-2provided by FlyBase
    Primary source
    FLYBASE:FBgn0037061
    Locus tag
    Dmel_CG12975
    See related
    AllianceGenome:FB:FBgn0037061
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RE57810; CG12975; Dmel\CG12975
    Summary
    Predicted to enable tRNA methyltransferase activator activity. Involved in rRNA methylation. Predicted to be part of tRNA (m2G10) methyltransferase complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human TRMT112 (tRNA methyltransferase activator subunit 11-2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Trmt112 in Genome Data Viewer
    Location:
    78C2-78C2; 3-47 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21215995..21216839, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21209095..21209939, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Terminal ADP-ribose protein glycohydrolase 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Integrin linked kinase Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding PubMed 
    enables protein heterodimerization activity  
    enables tRNA methyltransferase activator activity  
    Process Evidence Code Pubs
    involved_in maturation of LSU-rRNA  
    involved_in maturation of SSU-rRNA  
    involved_in positive regulation of rRNA processing  
    involved_in rRNA methylation PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    is_active_in nucleus  
    part_of tRNA (m2G10) methyltransferase complex  
    part_of tRNA (m2G10) methyltransferase complex  

    General protein information

    Preferred Names
    tRNA methyltransferase subunit 11-2
    Names
    CG12975-PA
    Trmt112-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      21215995..21216839 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141036.4 → NP_649293.1  tRNA methyltransferase subunit 11-2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649293.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A1B2AL65, Q9VP65
      Related
      FBpp0077965
      Conserved Domains (1) summary
      pfam03966
      Location:90 → 113
      Trm112p; Trm112p-like protein
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