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    mmm missing minor mitochondria [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38851, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mmmprovided by FlyBase
    Official Full Name
    missing minor mitochondriaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035799
    Locus tag
    Dmel_CG14838
    See related
    AllianceGenome:FB:FBgn0035799
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14838; Dmel\CG14838
    Summary
    Predicted to enable dynein heavy chain binding activity and dynein light chain binding activity. Involved in flagellated sperm motility. Located in sperm flagellum. Is expressed in gonad; spermatogonium; and spermatozoon. Orthologous to human DNAI3 (dynein axonemal intermediate chain 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mmm in Genome Data Viewer
    Location:
    66A6-66A6; 3-21 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (7583454..7587248)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (7576554..7580348)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene faulty attraction Neighboring gene testis-specific gamma-tubulin ring protein 84 Neighboring gene Puratrophin-1-like Neighboring gene long non-coding RNA:CR45866

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Impact of cilia-related genes on mitochondrial dynamics during Drosophila spermatogenesis. Bauerly E, et al. Dev Biol, 2022 Feb. PMID 34822845
    2. Environmental chemical mediated male reproductive toxicity: Drosophila melanogaster as an alternate animal model. Tiwari AK, et al. Theriogenology, 2011 Jul 15. PMID 21356551
    3. Diverse Roles of Axonemal Dyneins in Drosophila Auditory Neuron Function and Mechanical Amplification in Hearing. Karak S, et al. Sci Rep, 2015 Nov 26. PMID 26608786, Free PMC Article
    4. Functional analysis of the Drosophila embryonic germ cell transcriptome by RNA interference. Jankovics F, et al. PLoS One, 2014. PMID 24896584, Free PMC Article
    5. Structure and molecular basis of spermatid elongation in the Drosophila testis. Huang Q, et al. Open Biol, 2023 Nov. PMID 37935354, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables dynein heavy chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein light chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cilium movement involved in cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in flagellated sperm motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in inner dynein arm assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of inner dynein arm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sperm flagellum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    missing minor mitochondria
    Names
    CG14838-PA
    mmm-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      7583454..7587248
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139881.2 → NP_648138.1  missing minor mitochondria [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648138.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8WHE4, Q9VS90
      Related
      FBpp0076513
      Conserved Domains (3) summary
      COG2319
      Location:328 → 599
      WD40; WD40 repeat [General function prediction only]
      pfam09522
      Location:807 → 863
      RE_R_Pab1; R.Pab1 restriction endonuclease
      sd00039
      Location:462 → 505
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VS90 Q9VS90

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