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    Spn42De Serpin 42De [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35602, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Spn42Deprovided by FlyBase
    Official Full Name
    Serpin 42Deprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033115
    Locus tag
    Dmel_CG9460
    See related
    AllianceGenome:FB:FBgn0033115
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9460; Dmel\CG9460; dSERPINA1; spn42De
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of proteolysis. Predicted to be active in extracellular space. Is expressed in several structures, including embryonic dorsal epidermis; embryonic epipharynx; embryonic foregut; embryonic head epidermis; and embryonic hypopharynx. Human ortholog(s) of this gene implicated in Alzheimer's disease and familial encephalopathy with neuroserpin inclusion bodies. Orthologous to several human genes including SERPINI1 (serpin family I member 1) and SERPINI2 (serpin family I member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Spn42De in Genome Data Viewer
    Location:
    42D6-42D6; 2-55 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (6885552..6888262)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (2773057..2775767)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44169 Neighboring gene Serpin 42Db Neighboring gene Serpin 42Dc Neighboring gene Serpin 42Dd Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene missing-in-metastasis

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Serpin Facilitates Tumor-Suppressive Cell Competition by Blocking Toll-Mediated Yki Activation in Drosophila. Katsukawa M, et al. Curr Biol, 2018 Jun 4. PMID 29804808
    2. Stable Binding of the Conserved Transcription Factor Grainy Head to its Target Genes Throughout Drosophila melanogaster Development. Nevil M, et al. Genetics, 2017 Feb. PMID 28007888, Free PMC Article
    3. The Drosophila serpins: multiple functions in immunity and morphogenesis. Reichhart JM, et al. Methods Enzymol, 2011. PMID 21683256
    4. Identification and analysis of serpin-family genes by homology and synteny across the 12 sequenced Drosophilid genomes. Garrett M, et al. BMC Genomics, 2009 Oct 22. PMID 19849829, Free PMC Article
    5. Molecular phylogeny of the antiangiogenic and neurotrophic serpin, pigment epithelium derived factor in vertebrates. Xu X, et al. BMC Genomics, 2006 Oct 4. PMID 17020603, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serpin 42De
    Names
    CG9460-PA
    CG9460-PB
    Spn42De-PA
    Spn42De-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      6885552..6888262
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259226.2 → NP_001246155.1  serpin 42De, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246155.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K6Q4
      Conserved Domains (1) summary
      cd00172
      Location:13 → 383
      SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...

    2. NM_136402.4 → NP_610246.3  serpin 42De, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610246.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SZF4
      Related
      FBpp0085497
      Conserved Domains (1) summary
      cd00172
      Location:31 → 401
      SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K6Q4 A0A0B4K6Q4
    Q8SZF4 Q8SZF4

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