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    Dpit47 DNA polymerase interacting tpr containing protein of 47kD [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35565, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dpit47provided by FlyBase
    Official Full Name
    DNA polymerase interacting tpr containing protein of 47kDprovided by FlyBase
    Primary source
    FLYBASE:FBgn0266518
    Locus tag
    Dmel_CG3189
    See related
    AllianceGenome:FB:FBgn0266518
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3189; cn20; Dmel\CG3189
    Summary
    Enables Hsp70 protein binding activity and Hsp90 protein binding activity. Predicted to be involved in protein folding. Located in nucleoplasm. Orthologous to human TTC4 (tetratricopeptide repeat domain 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Dpit47 in Genome Data Viewer
    Location:
    42C3-42C3; 2-55 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (6660645..6662118, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (2548150..2549623, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene geminin Neighboring gene scrambled Neighboring gene long non-coding RNA:CR45128 Neighboring gene Adh transcription factor 1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. nalyot, a mutation of the Drosophila myb-related Adf1 transcription factor, disrupts synapse formation and olfactory memory. DeZazzo J, et al. Neuron, 2000 Jul. PMID 10939338
    2. Natural variation in sugar tolerance associates with changes in signaling and mitochondrial ribosome biogenesis. Melvin RG, et al. Elife, 2018 Nov 27. PMID 30480548, Free PMC Article
    3. The Drosophila Dpit47 protein is a nuclear Hsp90 co-chaperone that interacts with DNA polymerase alpha. Crevel G, et al. J Cell Sci, 2001 Jun. PMID 11493638
    4. Transcriptional signature of an adult brain tumor in Drosophila. Loop T, et al. BMC Genomics, 2004 Apr 16. PMID 15090076, Free PMC Article
    5. Systems genetics of complex traits in Drosophila melanogaster. Ayroles JF, et al. Nat Genet, 2009 Mar. PMID 19234471, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables Hsp70 protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables Hsp70 protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables Hsp90 protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables Hsp90 protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables Hsp90 protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA polymerase interacting tpr containing protein of 47kD
    Names
    CG3189-PA
    CG3189-PB
    Dpit47-PA
    Dpit47-PB
    cn20

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      6660645..6662118 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080367.3 → NP_525106.2  DNA polymerase interacting tpr containing protein of 47kD, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_525106.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1Z6M6, Q6NMU5
      Related
      FBpp0085479
      Conserved Domains (2) summary
      TIGR00990
      Location:84 → 179
      3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
      sd00006
      Location:91 → 119
      TPR; TPR repeat [structural motif]

    2. NM_001273800.1 → NP_001260729.1  DNA polymerase interacting tpr containing protein of 47kD, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260729.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1Z6M6, Q6NMU5
      Conserved Domains (2) summary
      TIGR00990
      Location:84 → 179
      3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
      sd00006
      Location:91 → 119
      TPR; TPR repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z6M6.1 A1Z6M6

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