cbt cabut [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: cbtprovided by FlyBase
Official Full Name: cabutprovided by FlyBase
Primary source: FLYBASE:FBgn0043364
Locus tag: Dmel_CG4427
See related: AllianceGenome:FB:FBgn0043364
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Cabot; Cabut; Cbt; CG4427; Dmel\CG4427; dTIEG; EP(2)2237; EP2237
Summary: Enables sequence-specific DNA binding activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; positive regulation of BMP signaling pathway; and wing disc development. Located in nucleus. Is expressed in several structures, including embryonic/larval midgut primordium; epithelium; germline cell; gut section; and imaginal disc. Orthologous to human KLF13 (KLF transcription factor 13). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (476446..479688, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (476446..479688, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

A stress-responsive miRNA regulates BMP signaling to maintain tissue homeostasis.
Title: A stress-responsive miRNA regulates BMP signaling to maintain tissue homeostasis.
The Kruppel-like factor Cabut has cell cycle regulatory properties similar to E2F1.
Title: The Krüppel-like factor Cabut has cell cycle regulatory properties similar to E2F1.
Cbt is a novel partner of Yki that is required as a transcriptional co-activator in growth control.
Title: Cabut/dTIEG associates with the transcription factor Yorkie for growth control.
perturbation of CBT levels leads to deregulation of the circadian transcriptome and circadian behavioral patterns.
Title: The transcription factor Cabut coordinates energy metabolism and the circadian clock in response to sugar sensing.
characterization of the molecular mechanisms of Cbt-mediated transcriptional control as well as of Cbt nuclear import
Title: Transcriptional activity and nuclear localization of Cabut, the Drosophila ortholog of vertebrate TGF-β-inducible early-response gene (TIEG) proteins.
Cabut is localized on the surface of mitotic chromosomes at all mitotic phases
Title: Expression of Drosophila Cabut during early embryogenesis, dorsal closure and nervous system development.
Cbt functions downstream of Jun regulating dpp expression in the leading edge cells during dorsal closure
Title: Cabut, a C2H2 zinc finger transcription factor, is required during Drosophila dorsal closure downstream of JNK signaling.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in dorsal closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory organ development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wing disc dorsal/ventral pattern formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in wing disc morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

Names: CG4427-PA; CG4427-PB; CG4427-PC; TGF-beta-inducible early gene; cabot; cbt-PA; cbt-PB; cbt-PC

NEW Try the new Transcript table

The following sections contain reference sequences that belong to a specific genome build. Explain