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    HisRS Histidyl-tRNA synthetase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32841, updated on 9-Dec-2024

    Summary

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    Official Symbol
    HisRSprovided by FlyBase
    Official Full Name
    Histidyl-tRNA synthetaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0027087
    Locus tag
    Dmel_CG6335
    See related
    AllianceGenome:FB:FBgn0027087
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Aats-his; CG6335; dHARS; Dmel\CG6335; Harsl; HRS; l(1)G0165; l(1)G0358
    Summary
    Predicted to enable RNA binding activity and histidine-tRNA ligase activity. Predicted to be involved in histidyl-tRNA aminoacylation and mitochondrial translation. Located in cytosol. Is expressed in adult gnathal ganglion; larval muscle system; and supraesophageal ganglion. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease, axonal type 2W; Perrault syndrome; and Usher syndrome type 3B. Orthologous to human HARS1 (histidyl-tRNA synthetase 1) and HARS2 (histidyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See HisRS in Genome Data Viewer
    Location:
    17C1-17C1; 1-60 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (18515428..18520445)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (18409461..18414478)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene gamma-glutamyl transpeptidase Neighboring gene uncharacterized protein Neighboring gene Beadex Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Adipocyte amino acid sensing controls adult germline stem cell number via the amino acid response pathway and independently of Target of Rapamycin signaling in Drosophila. Armstrong AR, et al. Development, 2014 Dec. PMID 25359724, Free PMC Article
    2. WRS-85D: A tryptophanyl-tRNA synthetase expressed to high levels in the developing Drosophila salivary gland. Seshaiah P, et al. Mol Biol Cell, 1999 May. PMID 10233165, Free PMC Article
    3. An SMN-dependent U12 splicing event essential for motor circuit function. Lotti F, et al. Cell, 2012 Oct 12. PMID 23063131, Free PMC Article
    4. Asparaginyl-tRNA Synthetase, a Novel Component of Hippo Signaling, Binds to Salvador and Enhances Yorkie-Mediated Tumorigenesis. Yeom E, et al. Front Cell Dev Biol, 2020. PMID 32117966, Free PMC Article
    5. Synaptotagmins are trafficked to distinct subcellular domains including the postsynaptic compartment. Adolfsen B, et al. J Cell Biol, 2004 Jul 19. PMID 15263020, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histidine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histidine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histidine-tRNA ligase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in histidyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in histidyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in histidyl-tRNA aminoacylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in mitochondrial translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Histidyl-tRNA synthetase
    Names
    CG6335-PA
    CG6335-PC
    CG6335-PD
    CG6335-PE
    HisRS-PA
    HisRS-PC
    HisRS-PD
    HisRS-PE
    hars
    NP_001259685.1
    NP_001259686.1
    NP_573305.2
    NP_728180.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      18515428..18520445
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272757.1 → NP_001259686.1  Histidyl-tRNA synthetase, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259686.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PHI2
      Conserved Domains (4) summary
      COG0124
      Location:88 → 551
      HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
      cd00773
      Location:104 → 442
      HisRS-like_core; Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent ...
      cd00859
      Location:457 → 547
      HisRS_anticodon; HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is ...
      cl00349
      Location:64 → 82
      S15_NS1_EPRS_RNA-bind; S15/NS1/EPRS_RNA-binding domain. This short domain consists of a helix-turn-helix structure, which can bind to several types of RNA. It is found in the ribosomal protein S15, the influenza A viral nonstructural protein (NSA) and in several eukaryotic ...

    2. NM_001272756.1 → NP_001259685.1  Histidyl-tRNA synthetase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259685.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PHI2
      Conserved Domains (4) summary
      COG0124
      Location:88 → 551
      HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
      cd00773
      Location:104 → 442
      HisRS-like_core; Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent ...
      cd00859
      Location:457 → 547
      HisRS_anticodon; HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is ...
      cl00349
      Location:64 → 82
      S15_NS1_EPRS_RNA-bind; S15/NS1/EPRS_RNA-binding domain. This short domain consists of a helix-turn-helix structure, which can bind to several types of RNA. It is found in the ribosomal protein S15, the influenza A viral nonstructural protein (NSA) and in several eukaryotic ...

    3. NM_133077.2 → NP_573305.2  Histidyl-tRNA synthetase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573305.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IQX8
      Conserved Domains (4) summary
      COG0124
      Location:98 → 561
      HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
      cd00773
      Location:114 → 452
      HisRS-like_core; Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent ...
      cd00859
      Location:467 → 557
      HisRS_anticodon; HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is ...
      cl00349
      Location:6 → 92
      S15_NS1_EPRS_RNA-bind; S15/NS1/EPRS_RNA-binding domain. This short domain consists of a helix-turn-helix structure, which can bind to several types of RNA. It is found in the ribosomal protein S15, the influenza A viral nonstructural protein (NSA) and in several eukaryotic ...

    4. NM_167624.3 → NP_728180.1  Histidyl-tRNA synthetase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728180.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VWT1
      Related
      FBpp0074365
      Conserved Domains (4) summary
      COG0124
      Location:56 → 519
      HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
      cd00773
      Location:72 → 410
      HisRS-like_core; Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent ...
      cd00859
      Location:425 → 515
      HisRS_anticodon; HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is ...
      cd00938
      Location:6 → 50
      HisRS_RNA; HisRS_RNA binding domain. This short RNA-binding domain is found at the N-terminus of HisRS in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). This domain consists of a helix- turn- helix structure, which is similar to other RNA-binding ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PHI2 M9PHI2
    Q8IQX8 Q8IQX8
    Q9VWT1 Q9VWT1

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