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    NiPp1 Nuclear inhibitor of Protein phosphatase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44748, updated on 27-Dec-2024

    Summary

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    Official Symbol
    NiPp1provided by FlyBase
    Official Full Name
    Nuclear inhibitor of Protein phosphatase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0026402
    Locus tag
    Dmel_CG8980
    See related
    AllianceGenome:FB:FBgn0026402
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8980; Dmel\CG8980; NiPp-1; NIPP-1Dm; nipp1; NIPP1; NIPP1Dm
    Summary
    Enables mRNA binding activity; protein phosphatase 1 binding activity; and protein serine/threonine phosphatase inhibitor activity. Involved in axon guidance and positive regulation of BMP signaling pathway. Located in nuclear speck. Is expressed in organism. Orthologous to human PPP1R8 (protein phosphatase 1 regulatory subunit 8). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See NiPp1 in Genome Data Viewer
    Location:
    53E4-53E4; 2-81 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17003563..17005149, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12891068..12892654, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene ste24b prenyl protease type I Neighboring gene prenyl protease type I Neighboring gene Asparaginyl-tRNA synthetase, mitochondrial Neighboring gene uncharacterized protein Neighboring gene Eps15 homology domain containing protein-binding protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Vectors for the expression of tagged proteins in Drosophila. Parker L, et al. Biotechniques, 2001 Dec. PMID 11768656
    2. Juvenile Hormone Suppresses Resistance to Infection in Mated Female Drosophila melanogaster. Schwenke RA, et al. Curr Biol, 2017 Feb 20. PMID 28190728, Free PMC Article
    3. Functional interaction between nuclear inhibitor of protein phosphatase type 1 (NIPP1) and protein phosphatase type 1 (PP1) in Drosophila: consequences of over-expression of NIPP1 in flies and suppression by co-expression of PP1. Parker L, et al. Biochem J, 2002 Dec 15. PMID 12358598, Free PMC Article
    4. Hormonal control of motivational circuitry orchestrates the transition to sexuality in Drosophila. Zhang SX, et al. Sci Adv, 2021 Jun. PMID 34134981, Free PMC Article
    5. Cooperative interaction between phosphorylation sites on PERIOD maintains circadian period in Drosophila. Garbe DS, et al. PLoS Genet, 2013. PMID 24086144, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. nuclear inhibitor of protein phosphatase type 1 (NIPP1) and protein phosphatase type 1 (PP1c) interact in vivo in Drosophila
      Title: Functional interaction between nuclear inhibitor of protein phosphatase type 1 (NIPP1) and protein phosphatase type 1 (PP1) in Drosophila: consequences of over-expression of NIPP1 in flies and suppression by co-expression of PP1.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein phosphatase 1 binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein phosphatase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine phosphatase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine phosphatase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of BMP signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nuclear speck IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nuclear inhibitor of protein phosphatase 1
    Names
    CG8980-PA
    NiPp1-PA
    nuclear inhibitor of PP1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      17003563..17005149 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137333.4 → NP_611177.1  nuclear inhibitor of protein phosphatase 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611177.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V7W9
      Related
      FBpp0086206
      Conserved Domains (2) summary
      COG1716
      Location:40 → 87
      FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
      cd00060
      Location:18 → 110
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V7W9 Q9V7W9

    Gene LinkOut

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