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    Tfdp1 transcription factor Dp-1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361178, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Tfdp1provided by RGD
    Official Full Name
    transcription factor Dp-1provided by RGD
    Primary source
    RGD:1560344
    See related
    EnsemblRapid:ENSRNOG00000019222 AllianceGenome:RGD:1560344
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding activity; and cis-regulatory region sequence-specific DNA binding activity. Predicted to contribute to DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including negative regulation of fat cell proliferation; positive regulation of G1/S transition of mitotic cell cycle; and regulation of DNA-templated transcription. Predicted to act upstream of or within anoikis; epidermis development; and regulation of nucleobase-containing compound metabolic process. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of Rb-E2F complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in mismatch repair cancer syndrome. Orthologous to several human genes including TFDP1 (transcription factor Dp-1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Thymus (RPKM 213.1), Spleen (RPKM 176.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tfdp1 in Genome Data Viewer
    Location:
    16q12.5
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (82864220..82903166, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (76162040..76200871, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (81088642..81127244)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor kinase 1 Neighboring gene ATPase H+/K+ transporting subunit beta Neighboring gene uncharacterized LOC102548465 Neighboring gene transmembrane and coiled-coil domains 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The Interaction Mode of the Acidic Region of the Cell Cycle Transcription Factor DP1 with TFIIH. Okuda M, et al. J Mol Biol, 2016 Dec 4. PMID 27825926
    2. The DP-1 transcription factor is required for keratinocyte growth and epidermal stratification. Chang WY, et al. J Biol Chem, 2004 Dec 3. PMID 15448153
    3. Kelch Repeat and BTB Domain Containing Protein 5 (Kbtbd5) Regulates Skeletal Muscle Myogenesis through the E2F1-DP1 Complex. Gong W, et al. J Biol Chem, 2015 Jun 12. PMID 25940086, Free PMC Article
    4. Repression of transcriptional activity of C/EBPalpha by E2F-dimerization partner complexes. Zaragoza K, et al. Mol Cell Biol, 2010 May. PMID 20176812, Free PMC Article
    5. Functional analysis of bacterial artificial chromosomes in mammalian cells: mouse Cdc6 is associated with the mitotic spindle apparatus. Illenye S, et al. Genomics, 2004 Jan. PMID 14667810

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC112830

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    contributes_to DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within anoikis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within epidermis development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of fat cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of DNA biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Rb-E2F complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transcription factor Dp-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025718.1 → NP_001020889.1  transcription factor Dp-1

      Status: PROVISIONAL

      Source sequence(s)
      BC098789
      UniProtKB/TrEMBL
      Q4KM53
      Conserved Domains (3) summary
      cd14458
      Location:78 → 124
      DP_DD; coiled coil [structural motif]
      pfam02319
      Location:1 → 73
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain
      pfam08781
      Location:80 → 219
      DP; Transcription factor DP

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      82864220..82903166 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039094677.2 → XP_038950605.1  transcription factor Dp-1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JXN0, A6IWH7, G3V8H9
      Conserved Domains (3) summary
      cd14458
      Location:198 → 244
      DP_DD; coiled coil [structural motif]
      pfam02319
      Location:113 → 193
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain
      pfam08781
      Location:200 → 338
      DP; Transcription factor DP

    2. XM_039094682.2 → XP_038950610.1  transcription factor Dp-1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GIG6, A6IWH8
      Conserved Domains (3) summary
      cd14458
      Location:78 → 124
      DP_DD; coiled coil [structural motif]
      pfam02319
      Location:1 → 73
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain
      pfam08781
      Location:80 → 218
      DP; Transcription factor DP

    3. XM_039094676.2 → XP_038950604.1  transcription factor Dp-1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JXN0, A6IWH7, G3V8H9
      Related
      ENSRNOP00000070337.1, ENSRNOT00000087192.3
      Conserved Domains (3) summary
      cd14458
      Location:198 → 244
      DP_DD; coiled coil [structural motif]
      pfam02319
      Location:113 → 193
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain
      pfam08781
      Location:200 → 338
      DP; Transcription factor DP

    4. XM_008771398.4 → XP_008769620.1  transcription factor Dp-1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JXN0, A6IWH7, G3V8H9
      Conserved Domains (3) summary
      cd14458
      Location:198 → 244
      DP_DD; coiled coil [structural motif]
      pfam02319
      Location:113 → 193
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain
      pfam08781
      Location:200 → 338
      DP; Transcription factor DP

    5. XM_008771397.4 → XP_008769619.1  transcription factor Dp-1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JXN0, A6IWH7, G3V8H9
      Conserved Domains (3) summary
      cd14458
      Location:198 → 244
      DP_DD; coiled coil [structural motif]
      pfam02319
      Location:113 → 193
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain
      pfam08781
      Location:200 → 338
      DP; Transcription factor DP

    6. XM_063275572.1 → XP_063131642.1  transcription factor Dp-1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GIG6, A6IWH8

    7. XM_063275573.1 → XP_063131643.1  transcription factor Dp-1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GIG6, A6IWH8
      Related
      ENSRNOP00000089894.1, ENSRNOT00000096795.2
    Nucleotide Protein Strain
    Heading Accession and Version

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