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    Zcchc7 zinc finger, CCHC domain containing 7 [ Mus musculus (house mouse) ]

    Gene ID: 319885, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zcchc7provided by MGI
    Official Full Name
    zinc finger, CCHC domain containing 7provided by MGI
    Primary source
    MGI:MGI:2442912
    See related
    Ensembl:ENSMUSG00000035649 AllianceGenome:MGI:2442912
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D4Wsu132e; 4930572I07Rik
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in nuclear RNA surveillance. Predicted to be located in cytosol and nucleolus. Predicted to be part of TRAMP complex. Is expressed in several structures, including central nervous system; dorsal root ganglion; extraembryonic component; sensory organ; and vibrissa. Orthologous to human ZCCHC7 (zinc finger CCHC-type containing 7). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in bladder adult (RPKM 10.8), frontal lobe adult (RPKM 10.3) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zcchc7 in Genome Data Viewer
    Location:
    4 B1; 4 23.57 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (44756556..44932215)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (44756558..44932215)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene paired box 5 Neighboring gene RIKEN cDNA 5730488B01 gene Neighboring gene Pax5 promoter region Neighboring gene Pax5 mhb enhancer Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:44769412-44769521 Neighboring gene aurora kinase C pseudogene Neighboring gene STARR-seq mESC enhancer starr_10082 Neighboring gene STARR-positive B cell enhancer mm9_chr4:44899270-44899570 Neighboring gene STARR-positive B cell enhancer mm9_chr4:44918473-44918774 Neighboring gene STARR-positive B cell enhancer ABC_E11237 Neighboring gene STARR-seq mESC enhancer starr_10084 Neighboring gene predicted gene 12678 Neighboring gene predicted gene, 30763

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Ko MS, et al. Hum Mol Genet, 1998 Nov. PMID 9811942
    2. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article
    3. A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Mural RJ, et al. Science, 2002 May 31. PMID 12040188
    4. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article
    5. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC62855

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in TRAMP-dependent tRNA surveillance pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in nuclear mRNA surveillance of mRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear polyadenylation-dependent CUT catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear polyadenylation-dependent rRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear polyadenylation-dependent snRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear polyadenylation-dependent snoRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of TRAMP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger CCHC domain-containing protein 7
    Names
    TRAMP-like complex RNA-binding factor ZCCHC7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138590.4 → NP_613056.2  zinc finger CCHC domain-containing protein 7

      See identical proteins and their annotated locations for NP_613056.2

      Status: VALIDATED

      Source sequence(s)
      AA277854, AL805896, CF732773, CJ150974, CJ155194
      Consensus CDS
      CCDS18127.2
      UniProtKB/Swiss-Prot
      B1AX39, Q3TZN5, Q8C915, Q9CYZ9
      Related
      ENSMUSP00000103454.3, ENSMUST00000107824.9
      Conserved Domains (1) summary
      COG5082
      Location:233 → 362
      AIR1; Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      44756556..44932215
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006537985.4 → XP_006538048.1  zinc finger CCHC domain-containing protein 7 isoform X2

      Conserved Domains (1) summary
      COG5082
      Location:233 → 362
      AIR1; Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

    2. XM_006537984.5 → XP_006538047.1  zinc finger CCHC domain-containing protein 7 isoform X1

      See identical proteins and their annotated locations for XP_006538047.1

      UniProtKB/Swiss-Prot
      B1AX39, Q3TZN5, Q8C915, Q9CYZ9
      Conserved Domains (1) summary
      COG5082
      Location:233 → 362
      AIR1; Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

    3. XM_006537986.4 → XP_006538049.1  zinc finger CCHC domain-containing protein 7 isoform X3

      Conserved Domains (1) summary
      COG5082
      Location:86 → 215
      AIR1; Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

    RNA

    1. XR_004941921.1 RNA Sequence

    2. XR_003954962.2 RNA Sequence

    3. XR_003954965.2 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_177027.3: Suppressed sequence

      Description
      NM_177027.3: This RefSeq was permanently suppressed because the transcript was incompletely processed at the 3' end.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B1AX39.1 GenPept UniProtKB/Swiss-Prot:B1AX39

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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