TTG2 WRKY family transcription factor family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: TTG2
Official Full Name: WRKY family transcription factor family protein
Primary source: TAIR:AT2G37260
Locus tag: AT2G37260
See related: Araport:AT2G37260
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATWRKY44; DR. STRANGELOVE 1; DSL1; F3G5.5; F3G5_5; TRANSPARENT TESTA GLABRA 2; WRKY44
Summary: Encodes a protein similar to WRKY transcription factors that is expressed in the seed integument and endosperm. Mutants are defective in proanthocyanidin synthesis and seed mucilate deposition. Seeds are yellow colored. Seed size is also affected; seeds are reduced in size but only when the mutant allele is transmitted through the female parent.Loss of function alleles are associated with a reduction in interploidy lethality.
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Genomic context

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See TTG2 in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 5

Sequence:: Chromosome: 2; NC_003071.7 (15644811..15647076)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TRANSPARENT TESTA GLABRA2 defines trichome cell shape by modulating actin cytoskeleton in Arabidopsis thaliana.
Title: TRANSPARENT TESTA GLABRA2 defines trichome cell shape by modulating actin cytoskeleton in Arabidopsis thaliana.
Genetic interaction between TTG2 and AtPLC1 reveals a role for phosphoinositide signaling in a co-regulated suite of Arabidopsis epidermal pathways.
Title: Genetic interaction between TTG2 and AtPLC1 reveals a role for phosphoinositide signaling in a co-regulated suite of Arabidopsis epidermal pathways.
TOP1alpha, UPF1, and TTG2 regulate seed size in a parental dosage-dependent manner.
Title: TOP1α, UPF1, and TTG2 regulate seed size in a parental dosage-dependent manner.
TTG2 regulates two vacuolar transport genes, TT12 and AHA10. TTG2 is dependent on TTG1 WDR protein. TTG2 and TTG1 physically interact.TTG2 can bind to the upstream regulatory region of TT12 suggesting that TTG2 directly regulates TT12.
Title: TTG2 controls the developmental regulation of seed coat tannins in Arabidopsis by regulating vacuolar transport steps in the proanthocyanidin pathway.
Data show that TRANSPARENT TESTA GLABRA 2 (TTG2) is a specific activator of TRYPTICHON protein (TRY) by binding to W-boxes in a minimal promoter fragment of TRY.
Title: Arabidopsis TTG2 regulates TRY expression through enhancement of activator complex-triggered activation.
GIGANTEA-miRNA172-WRKY44 may regulate drought escape and drought tolerance by affecting sugar signaling in Arabidopsis.
Title: The suppression of WRKY44 by GIGANTEA-miR172 pathway is involved in drought response of Arabidopsis thaliana.
the role of the sporophytically active TTG2 gene in interploidy crosses indicates that the developmental programming of the mother regulates the viability of interploidy hybrid offspring.
Title: The maternally expressed WRKY transcription factor TTG2 controls lethality in interploidy crosses of Arabidopsis.
Complexes containing R2R3 MYB and bHLH transcription factors regulate the expression of TTG2, which then regulates GL2 expression with complexes containing R2R3 MYB.
Title: Arabidopsis TRANSPARENT TESTA GLABRA2 is directly regulated by R2R3 MYB transcription factors and is involved in regulation of GLABRA2 transcription in epidermal differentiation.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001084546.1

Supported by ESTs:

NM_001336644.1

Supported by ESTs:

NM_129282.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within plant epidermal cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within seed coat development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: WRKY family transcription factor family protein

NP_001078015.1

TRANSPARENT TESTA GLABRA 2 (TTG2); CONTAINS InterPro DOMAIN/s: DNA-binding WRKY (InterPro:IPR003657); BEST Arabidopsis thaliana protein match is: WRKY DNA-binding protein 3 (TAIR:AT2G03340.1); Has 5962 Blast hits to 3069 proteins in 194 species: Archae - 0; Bacteria - 4; Metazoa - 2; Fungi - 0; Plants - 5906; Viruses - 0; Other Eukaryotes - 50 (source: NCBI BLink).

NP_181263.2

TRANSPARENT TESTA GLABRA 2 (TTG2); CONTAINS InterPro DOMAIN/s: DNA-binding WRKY (InterPro:IPR003657); BEST Arabidopsis thaliana protein match is: WRKY DNA-binding protein 3 (TAIR:AT2G03340.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

15644811..15647076

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_129282.4 → NP_181263.2 WRKY family transcription factor family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_181263.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9ZUU0

UniProtKB/TrEMBL

A0A178VZZ8, A0A384L2V3, A7BI37

Conserved Domains (1) summary

smart00774
Location:348 → 405

WRKY; DNA binding domain
NM_001084546.1 → NP_001078015.1 WRKY family transcription factor family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001078015.1

Status: REVIEWED

UniProtKB/TrEMBL

A8MRJ2

Conserved Domains (1) summary

smart00774
Location:266 → 323

WRKY; DNA binding domain
NM_001336644.1 → NP_001323504.1 WRKY family transcription factor family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

C0SV76