PP2A-2 protein phosphatase 2A-2 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: PP2A-2
Official Full Name: protein phosphatase 2A-2
Primary source: TAIR:AT1G10430
Locus tag: AT1G10430
See related: Araport:AT1G10430
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: PROTEIN PHOSPHATASE 2A; protein phosphatase 2A-2; T10O24.4; T10O24_4
Summary: Encodes one of the isoforms of the catalytic subunit of protein phosphatase 2A: AT1G59830/PP2A-1, AT1G10430/PP2A-2, At2g42500/PP2A-3, At3g58500/PP2A-4 [Plant Molecular Biology (1993) 21:475-485 and (1994) 26:523-528; Note that in more recent publications, there is mixed use of gene names for PP2A-3 and PP2A-4 - some refer to At2g42500 as PP2A-3 and some as PP2A-4]. It regulates the activation of ADF/cofilin, which, in turn, regulates actin cytoskeleton remodeling and is involved in phot2-mediated chloroplast avoidance movements.
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Genomic context

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See PP2A-2 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 7

Sequence:: Chromosome: 1; NC_003070.9 (3428478..3430924, complement)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PP2A-2 regulated the activation of ADF/cofilin, which, in turn, regulated actin cytoskeleton remodeling and was involved in phot2-mediated chloroplast avoidance movements.
Title: A protein phosphatase 2A catalytic subunit modulates blue light-induced chloroplast avoidance movements through regulating actin cytoskeleton in Arabidopsis.
Phenotypic, genetic and gene expression data strongly suggest that PP2Ac-2 is a negative regulator of the abscisic acid pathway.
Title: A protein phosphatase 2A catalytic subunit is a negative regulator of abscisic acid signalling.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_100918.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within chloroplast avoidance movement	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of abscisic acid-activated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of fatty acid beta-oxidation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein dephosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein dephosphorylation	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
NOT located_in cytosol	RCA inferred from Reviewed Computational Analysis more info	PubMed
located_in nucleus	HDA more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	HDA more info	PubMed

General protein information

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Preferred Names: protein phosphatase 2A-2

NP_172514.1

protein phosphatase 2A-2 (PP2A-2); FUNCTIONS IN: protein serine/threonine phosphatase activity; INVOLVED IN: biological_process unknown; LOCATED IN: nucleus, plasma membrane, cytoplasm; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Metallophosphoesterase (InterPro:IPR004843), Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase (InterPro:IPR006186); BEST Arabidopsis thaliana protein match is: protein phosphatase 2A-2 (TAIR:AT1G59830.1); Has 6751 Blast hits to 6569 proteins in 471 species: Archae - 80; Bacteria - 183; Metazoa - 2378; Fungi - 1410; Plants - 970; Viruses - 5; Other Eukaryotes - 1725 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

3428478..3430924 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001331905.1 → NP_001322206.1 protein phosphatase 2A-2 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q07098

UniProtKB/TrEMBL

A0A178W6R4, A0A5S9TMG9, A0A7G2E239

Conserved Domains (1) summary

cd07415
Location:6 → 290

MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain
NM_100918.3 → NP_172514.1 protein phosphatase 2A-2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_172514.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q07098

UniProtKB/TrEMBL

A0A178W6R4, A0A5S9TMG9, A0A7G2E239

Conserved Domains (1) summary

cd07415
Location:6 → 290

MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain