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    GPX4 glutathione peroxidase 4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819427, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GPX4
    Official Full Name
    glutathione peroxidase 4
    Primary source
    TAIR:AT2G48150
    Locus tag
    AT2G48150
    See related
    Araport:AT2G48150
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATGPX4; F11L15.5; glutathione peroxidase 4
    Summary
    Encodes glutathione peroxidase.
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    Genomic context

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    See GPX4 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    6
    Sequence:
    Chromosome: 2; NC_003071.7 (19687831..19689229, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein Neighboring gene Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein Neighboring gene ncRNA Neighboring gene Tudor/PWWP/MBT domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Glutathione peroxidase-like enzymes cover five distinct cell compartments and membrane surfaces in Arabidopsis thaliana. Attacha S, et al. Plant Cell Environ, 2017 Aug. PMID 28102911
    2. Glutathione peroxidase genes in Arabidopsis are ubiquitous and regulated by abiotic stresses through diverse signaling pathways. Rodriguez Milla MA, et al. Plant J, 2003 Dec. PMID 14617062
    3. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article
    4. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    NM_001337302.1
    NM_130382.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables glutathione peroxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in cytosol NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in endomembrane system IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glutathione peroxidase 4
    NP_566128.1
    • glutathione peroxidase 4 (GPX4); FUNCTIONS IN: glutathione peroxidase activity; INVOLVED IN: oxidation reduction, response to oxidative stress, N-terminal protein myristoylation; LOCATED IN: cytosol; EXPRESSED IN: 6 plant structures; EXPRESSED DURING: L mature pollen stage, M germinated pollen stage, 4 anthesis, petal differentiation and expansion stage; CONTAINS InterPro DOMAIN/s: Thioredoxin fold (InterPro:IPR012335), Thioredoxin-like fold (InterPro:IPR012336), Glutathione peroxidase (InterPro:IPR000889); BEST Arabidopsis thaliana protein match is: glutathione peroxidase 5 (TAIR:AT3G63080.1); Has 7346 Blast hits to 7345 proteins in 1724 species: Archae - 2; Bacteria - 3554; Metazoa - 785; Fungi - 210; Plants - 383; Viruses - 8; Other Eukaryotes - 2404 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      19687831..19689229 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_130382.2 → NP_566128.1  glutathione peroxidase 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566128.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8L910
      UniProtKB/TrEMBL
      A0A178VXC8, A0A5S9X803
      Conserved Domains (1) summary
      cd00340
      Location:11 → 163
      GSH_Peroxidase; Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per ...

    2. NM_001337302.1 → NP_001324284.1  glutathione peroxidase 4 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AZN1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8L910.1

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