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    PHV Homeobox-leucine zipper family protein / lipid-binding START domain-containing protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 839928, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PHV
    Official Full Name
    Homeobox-leucine zipper family protein / lipid-binding START domain-containing protein
    Primary source
    TAIR:AT1G30490
    Locus tag
    AT1G30490
    See related
    Araport:AT1G30490
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATHB9; F26G16.11; F26G16_11; PHAVOLUTA
    Summary
    Dominant PHV mutations cause transformation of abaxial leaf fates into adaxial leaf fates. Has overlapping functions with PHABULOSA, REVOLUTA and CORONA/ATHB15 in patterning the apical portion of the embryo. Encodes a member of HD-Zip family which contains homeodomain-leucine zipper domains and domain similar to a mammalian sterol binding domain.
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    Genomic context

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    See PHV in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    18
    Sequence:
    Chromosome: 1; NC_003070.9 (10796124..10801093, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Heavy metal transport/detoxification superfamily protein Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene D111/G-patch domain-containing protein Neighboring gene ncRNA Neighboring gene nuclear factor Y, subunit A7

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Conserved homeodomain cysteines confer redox sensitivity and influence the DNA binding properties of plant class III HD-Zip proteins. Comelli RN, et al. Arch Biochem Biophys, 2007 Nov 1. PMID 17900520
    2. Role of PHABULOSA and PHAVOLUTA in determining radial patterning in shoots. McConnell JR, et al. Nature, 2001 Jun 7. PMID 11395776
    3. The AP2 transcription factors DORNROSCHEN and DORNROSCHEN-LIKE redundantly control Arabidopsis embryo patterning via interaction with PHAVOLUTA. Chandler JW, et al. Development, 2007 May. PMID 17376809
    4. A WUSCHEL-Independent Stem Cell Specification Pathway Is Repressed by PHB, PHV and CNA in Arabidopsis. Lee C, et al. PLoS One, 2015. PMID 26011610, Free PMC Article
    5. Roles of polarity determinants in ovule development. Kelley DR, et al. Plant J, 2009 Mar. PMID 19054366, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The branching ovules of the mutant resemble those of some fossil gymnosperms, implicating BEL1 and HD-ZIPIII genes as players in the evolution of the unbranched ovule form in extant angiosperms.
      Title: CORONA, PHABULOSA and PHAVOLUTA collaborate with BELL1 to confine WUSCHEL expression to the nucellus in Arabidopsis ovules.
    2. stem cell specification pathway is normally repressed by the activity of the HD-zip III transcription factors PHABULOSA (PHB), PHAVOLUTA (PHV) and CORONA (CNA).
      Title: A WUSCHEL-Independent Stem Cell Specification Pathway Is Repressed by PHB, PHV and CNA in Arabidopsis.
    3. Athb-9 is sensitive to redox conditions
      Title: Conserved homeodomain cysteines confer redox sensitivity and influence the DNA binding properties of plant class III HD-Zip proteins.
    4. A yeast two-hybrid screen with DRN followed by co-immunoprecipitation and bimolecular fluorescence complementation revealed PHAVOLUTA (PHV) to be a protein interaction partner in planta
      Title: The AP2 transcription factors DORNROSCHEN and DORNROSCHEN-LIKE redundantly control Arabidopsis embryo patterning via interaction with PHAVOLUTA.
    5. Class III HD-Zip AND KANADI genes required for root development [PHAVOLUTA (PHV)]
      Title: Roles for Class III HD-Zip and KANADI genes in Arabidopsis root development.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_102785.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within adaxial/abaxial axis specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within determination of bilateral symmetry IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within embryonic pattern specification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within integument development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within meristem initiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within polarity specification of adaxial/abaxial axis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within primary shoot apical meristem specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Homeobox-leucine zipper family protein / lipid-binding START domain-containing protein
    NP_174337.1
    • PHAVOLUTA (PHV); CONTAINS InterPro DOMAIN/s: Homeobox (InterPro:IPR001356), Homeodomain-like (InterPro:IPR009057), Lipid-binding START (InterPro:IPR002913), MEKHLA (InterPro:IPR013978), Homeodomain-related (InterPro:IPR012287); BEST Arabidopsis thaliana protein match is: Homeobox-leucine zipper family protein / lipid-binding START domain-containing protein (TAIR:AT2G34710.1); Has 3472 Blast hits to 3351 proteins in 286 species: Archae - 0; Bacteria - 32; Metazoa - 920; Fungi - 121; Plants - 2372; Viruses - 0; Other Eukaryotes - 27 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      10796124..10801093 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_102785.5 → NP_174337.1  Homeobox-leucine zipper family protein / lipid-binding START domain-containing protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_174337.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O04292, Q56ZC0, Q9S9Q0
      UniProtKB/TrEMBL
      A0A178WF17, A0A5S9WEB0
      Conserved Domains (4) summary
      cd08875
      Location:164 → 380
      START_ArGLABRA2_like; C-terminal lipid-binding START domain of the Arabidopsis homeobox protein GLABRA 2 and related proteins
      cd14686
      Location:73 → 112
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
      pfam00046
      Location:21 → 79
      Homeobox; Homeobox domain
      pfam08670
      Location:695 → 840
      MEKHLA; MEKHLA domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O04292.1

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