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    ROPGEF12 RHO guanyl-nucleotide exchange factor 12 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 844325, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ROPGEF12
    Official Full Name
    RHO guanyl-nucleotide exchange factor 12
    Primary source
    TAIR:AT1G79860
    Locus tag
    AT1G79860
    See related
    Araport:AT1G79860
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATROPGEF12; F19K16.18; F19K16_18; KINASE PARTNER PROTEIN-LIKE; KPP-LIKE; MATERNAL EFFECT EMBRYO ARREST 64; MEE64; RHO guanyl-nucleotide exchange factor 12; ROP (rho of plants) guanine nucleotide exchange factor 12
    Summary
    Encodes a member of KPP-like gene family, homolog of KPP (kinase partner protein) gene in tomato. Also a member of the RopGEF (guanine nucleotide exchange factor) family, containing the novel PRONE domain (plant-specific Rop nucleotide exchanger), which is exclusively active towards members of the Rop subfamily. Coexpression of AtPRK2a with AtRopGEF12 resulted in isotropic pollen tube growth Growth.
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    Genomic context

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    See ROPGEF12 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    5
    Sequence:
    Chromosome: 1; NC_003070.9 (30041989..30044297, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Major facilitator superfamily protein Neighboring gene golgin Putative 5 Neighboring gene HD-ZIP IV family of homeobox-leucine zipper protein with lipid-binding START domain-containing protein Neighboring gene ncRNA Neighboring gene ribosomal protein S17 Neighboring gene D-isomer specific 2-hydroxyacid dehydrogenase family protein Neighboring gene RAD3-like DNA-binding helicase protein Neighboring gene RNA recognition motif (RRM)-containing protein Neighboring gene Mitochondrial substrate carrier family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The juxtamembrane and carboxy-terminal domains of Arabidopsis PRK2 are critical for ROP-induced growth in pollen tubes. Zhao XY, et al. J Exp Bot, 2013 Dec. PMID 24136420, Free PMC Article
    2. A distinct mechanism regulating a pollen-specific guanine nucleotide exchange factor for the small GTPase Rop in Arabidopsis thaliana. Zhang Y, et al. Proc Natl Acad Sci U S A, 2007 Nov 20. PMID 18000057, Free PMC Article
    3. AtPRK2 promotes ROP1 activation via RopGEFs in the control of polarized pollen tube growth. Chang F, et al. Mol Plant, 2013 Jul. PMID 23024212, Free PMC Article
    4. Members of a novel class of Arabidopsis Rho guanine nucleotide exchange factors control Rho GTPase-dependent polar growth. Gu Y, et al. Plant Cell, 2006 Feb. PMID 16415208, Free PMC Article
    5. A new family of RhoGEFs activates the Rop molecular switch in plants. Berken A, et al. Nature, 2005 Aug 25. PMID 15980860

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AtPRK2-induced tube depolarization depends on its interaction with RopGEF12.
      Title: The juxtamembrane and carboxy-terminal domains of Arabidopsis PRK2 are critical for ROP-induced growth in pollen tubes.
    2. AtRopGEF12 interacts with an Arabidopsis pollen receptor kinase AtPRK2a through its C terminus, and BiFC to show that they interact in pollen tubes
      Title: A distinct mechanism regulating a pollen-specific guanine nucleotide exchange factor for the small GTPase Rop in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within embryo development ending in seed dormancy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen tube growth IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of pollen tube growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in pollen tube IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    RHO guanyl-nucleotide exchange factor 12
    NP_178104.1
    • RHO guanyl-nucleotide exchange factor 12 (ROPGEF12); CONTAINS InterPro DOMAIN/s: Rop nucleotide exchanger, PRONE (InterPro:IPR005512); BEST Arabidopsis thaliana protein match is: RHO guanyl-nucleotide exchange factor 11 (TAIR:AT1G52240.1); Has 305 Blast hits to 303 proteins in 16 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 305; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      30041989..30044297 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_106635.4 → NP_178104.1  RHO guanyl-nucleotide exchange factor 12 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_178104.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9CA89
      UniProtKB/TrEMBL
      A0A178WIS4, A0A5S9WVW2
      Conserved Domains (1) summary
      pfam03759
      Location:91 → 441
      PRONE; PRONE (Plant-specific Rop nucleotide exchanger)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CA89.1

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