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    HES1 hes family bHLH transcription factor 1 [ Homo sapiens (human) ]

    Gene ID: 3280, updated on 4-Jan-2025

    Summary

    Official Symbol
    HES1provided by HGNC
    Official Full Name
    hes family bHLH transcription factor 1provided by HGNC
    Primary source
    HGNC:HGNC:5192
    See related
    Ensembl:ENSG00000114315 MIM:139605; AllianceGenome:HGNC:5192
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HHL; HRY; HES-1; bHLHb39
    Summary
    This protein belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in prostate (RPKM 46.7), thyroid (RPKM 44.9) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See HES1 in Genome Data Viewer
    Location:
    3q29
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (194136148..194138732)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (196832819..196835403)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (193853937..193856521)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2026 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr3:193714630-193715557 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15011 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:193721507-193722022 Neighboring gene developmental pluripotency associated 2 pseudogene 3 Neighboring gene long intergenic non-protein coding RNA 2028 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:193749967-193750544 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:193774732-193775677 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21011 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:193780351-193780851 Neighboring gene uncharacterized LOC102724877 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15012 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21012 Neighboring gene Sharpr-MPRA regulatory region 14852 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21013 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21014 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15013 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15014 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:193853895-193855094 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15015 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21016 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:193858467-193859461 Neighboring gene RNA, 7SL, cytoplasmic 215, pseudogene Neighboring gene uncharacterized LOC107986172 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:193878773-193879704

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of hairy and enhancer of split 1 (HES1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • FLJ20408

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific  
    enables E-box binding  
    enables E-box binding  
    enables HLH domain binding  
    enables JUN kinase binding  
    enables N-box binding  
    enables N-box binding  
    enables RNA polymerase II-specific DNA-binding transcription factor binding  
    enables chromatin binding  
    enables histone deacetylase binding PubMed 
    enables protein binding PubMed 
    enables protein homodimerization activity  
    enables protein-containing complex binding  
    enables protein-folding chaperone binding  
    enables sequence-specific DNA binding  
    enables sequence-specific double-stranded DNA binding PubMed 
    enables transcription corepressor binding  
    Items 1 - 25 of 96
    Process Evidence Code Pubs
    involved_in BMP signaling pathway  
    involved_in Cajal-Retzius cell differentiation  
    involved_in Notch signaling pathway  
    involved_in Notch signaling pathway PubMed 
    involved_in Notch signaling pathway PubMed 
    involved_in S-shaped body morphogenesis  
    involved_in T cell proliferation  
    involved_in adenohypophysis development  
    involved_in amacrine cell differentiation  
    involved_in anterior/posterior pattern specification  
    involved_in artery morphogenesis  
    involved_in ascending aorta morphogenesis  
    involved_in cardiac neural crest cell development involved in outflow tract morphogenesis  
    involved_in cell adhesion  
    involved_in cell fate determination  
    involved_in cell maturation  
    involved_in cell migration  
    involved_in cell morphogenesis involved in neuron differentiation  
    involved_in cellular response to fatty acid  
    involved_in cellular response to interleukin-1  
    involved_in cellular response to nerve growth factor stimulus  
    involved_in cellular response to tumor necrosis factor  
    involved_in cochlea development  
    involved_in comma-shaped body morphogenesis  
    involved_in common bile duct development  
    involved_in embryonic heart tube morphogenesis  
    involved_in establishment of epithelial cell polarity  
    involved_in forebrain radial glial cell differentiation  
    involved_in glomerulus vasculature development  
    involved_in hindbrain morphogenesis  
    involved_in inner ear auditory receptor cell differentiation  
    involved_in inner ear receptor cell stereocilium organization  
    involved_in labyrinthine layer blood vessel development  
    involved_in lateral inhibition  
    involved_in liver development  
    involved_in lung development  
    involved_in metanephric nephron tubule morphogenesis  
    involved_in midbrain development  
    involved_in midbrain-hindbrain boundary morphogenesis  
    involved_in negative regulation of DNA-binding transcription factor activity  
    involved_in negative regulation of DNA-templated transcription PubMed 
    involved_in negative regulation of amacrine cell differentiation  
    involved_in negative regulation of calcium ion import  
    involved_in negative regulation of cell fate determination  
    involved_in negative regulation of forebrain neuron differentiation  
    involved_in negative regulation of gene expression  
    involved_in negative regulation of glial cell proliferation  
    involved_in negative regulation of inner ear auditory receptor cell differentiation  
    involved_in negative regulation of neuron differentiation  
    involved_in negative regulation of neuron projection development  
    involved_in negative regulation of oligodendrocyte differentiation  
    involved_in negative regulation of pancreatic A cell differentiation  
    involved_in negative regulation of pro-B cell differentiation PubMed 
    involved_in negative regulation of stem cell differentiation PubMed 
    involved_in negative regulation of stomach neuroendocrine cell differentiation  
    involved_in negative regulation of transcription by RNA polymerase II PubMed 
    involved_in nervous system development PubMed 
    involved_in neuronal stem cell population maintenance PubMed 
    involved_in oculomotor nerve development  
    involved_in outflow tract morphogenesis  
    involved_in pancreatic A cell differentiation  
    involved_in pharyngeal arch artery morphogenesis  
    involved_in positive regulation of BMP signaling pathway  
    involved_in positive regulation of DNA binding  
    involved_in positive regulation of Notch signaling pathway  
    involved_in positive regulation of T cell proliferation  
    involved_in positive regulation of astrocyte differentiation  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of mitotic cell cycle, embryonic  
    involved_in positive regulation of receptor signaling pathway via JAK-STAT  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of tyrosine phosphorylation of STAT protein  
    involved_in protein-containing complex assembly  
    involved_in regulation of epithelial cell proliferation  
    involved_in regulation of fat cell differentiation  
    involved_in regulation of neurogenesis  
    involved_in regulation of protein-containing complex assembly  
    involved_in regulation of receptor signaling pathway via JAK-STAT  
    involved_in regulation of secondary heart field cardioblast proliferation  
    involved_in regulation of timing of neuron differentiation  
    involved_in regulation of transcription by RNA polymerase II  
    involved_in renal interstitial fibroblast development  
    involved_in response to alkaloid  
    involved_in response to organic cyclic compound  
    involved_in response to thyroid hormone  
    involved_in smoothened signaling pathway  
    involved_in somatic stem cell population maintenance  
    involved_in stomach neuroendocrine cell differentiation  
    involved_in telencephalon development  
    involved_in thymus development  
    involved_in trochlear nerve development  
    involved_in ureteric bud morphogenesis  
    involved_in vascular associated smooth muscle cell development  
    involved_in ventricular septum development  
    involved_in ventricular septum morphogenesis  
    Items 1 - 25 of 96
    Component Evidence Code Pubs
    located_in chromatin  
    located_in cytoplasm  
    located_in nuclear matrix  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus  
    part_of protein-containing complex  

    General protein information

    Preferred Names
    transcription factor HES-1
    Names
    class B basic helix-loop-helix protein 39
    hairy homolog
    hairy-like protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005524.4 → NP_005515.1  transcription factor HES-1

      See identical proteins and their annotated locations for NP_005515.1

      Status: REVIEWED

      Source sequence(s)
      AC080129, AI370424, AK000415
      Consensus CDS
      CCDS3305.1
      UniProtKB/Swiss-Prot
      Q14469, Q6FHB2
      UniProtKB/TrEMBL
      Q8IXV0
      Related
      ENSP00000232424.3, ENST00000232424.4
      Conserved Domains (2) summary
      cd11459
      Location:33 → 95
      bHLH-O_HES1_4; basic helix-loop-helix-orange (bHLH-O) domain found in hairy and enhancer of split HES-1, HES-4 and similar proteins
      pfam07527
      Location:110 → 148
      Hairy_orange; Hairy Orange

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      194136148..194138732
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      196832819..196835403
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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