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    SGT UDP-Glycosyltransferase superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819887, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SGT
    Official Full Name
    UDP-Glycosyltransferase superfamily protein
    Primary source
    TAIR:AT3G07020
    Locus tag
    AT3G07020
    See related
    Araport:AT3G07020
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    sterol glucosyltransferase; UDP-glucosyl transferase 80A2; UGT80A2
    Summary
    encodes a 3beta-hydroxy sterol UDP-glucosyltransferase. ugt80a2 mutant plants have reduced steryl glycoside and acyl steryl glycoside levels and reduced seed size. ugt80a2/b1 double mutants have normal levels of celluose and normal cold stress tolerance.
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    Genomic context

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    See SGT in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    15
    Sequence:
    Chromosome: 3; NC_003074.8 (2217622..2221956, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Cysteine/Histidine-rich C1 domain family protein Neighboring gene Pectin lyase-like superfamily protein Neighboring gene low-molecular-weight cysteine-rich 43 Neighboring gene tRNA-Val Neighboring gene Alba DNA/RNA-binding protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and characterization of one member of 3beta-hydroxy sterol glucosyltransferase gene family in Withania somnifera. Sharma LK, et al. Arch Biochem Biophys, 2007 Apr 1. PMID 17324374
    2. Mutations in UDP-Glucose:sterol glucosyltransferase in Arabidopsis cause transparent testa phenotype and suberization defect in seeds. DeBolt S, et al. Plant Physiol, 2009 Sep. PMID 19641030, Free PMC Article
    3. Functional diversification of two UGT80 enzymes required for steryl glucoside synthesis in Arabidopsis. Stucky DF, et al. J Exp Bot, 2015 Jan. PMID 25316063, Free PMC Article
    4. Large-scale analysis of in vivo phosphorylated membrane proteins by immobilized metal ion affinity chromatography and mass spectrometry. Nühse TS, et al. Mol Cell Proteomics, 2003 Nov. PMID 14506206
    5. Arabidopsis G-protein interactome reveals connections to cell wall carbohydrates and morphogenesis. Klopffleisch K, et al. Mol Syst Biol, 2011 Sep 27. PMID 21952135, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Both UGT80A2 and UGT80B1, but not UGT713B1 were shown to be coordinately down-regulated during seed imbibition when SG levels decline, consistent with similar functions as UGT80 enzymes.
      Title: Functional diversification of two UGT80 enzymes required for steryl glucoside synthesis in Arabidopsis.
    2. Arabidopsis lines having mutations in UGT80A2, UGT80B1, or both UGT80A2 and UGT80B1 were identified and characterized.
      Title: Mutations in UDP-Glucose:sterol glucosyltransferase in Arabidopsis cause transparent testa phenotype and suberization defect in seeds.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001337686.1
    NM_111582.3
    NM_180198.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables glycosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables sterol 3-beta-glucosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sterol 3-beta-glucosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT involved_in cellulose biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    NOT involved_in cold acclimation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in lipid glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within seed development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within sterol metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    UDP-Glycosyltransferase superfamily protein
    NP_566297.2
    • UDP-Glycosyltransferase superfamily protein; FUNCTIONS IN: transferase activity, transferring glycosyl groups; INVOLVED IN: lipid glycosylation, carbohydrate metabolic process, metabolic process; LOCATED IN: plasma membrane, membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Glycosyl transferase, family 28 (InterPro:IPR004276), UDP-glucuronosyl/UDP-glucosyltransferase (InterPro:IPR002213); BEST Arabidopsis thaliana protein match is: UDP-Glycosyltransferase superfamily protein (TAIR:AT1G43620.3); Has 2464 Blast hits to 2426 proteins in 636 species: Archae - 0; Bacteria - 1528; Metazoa - 298; Fungi - 386; Plants - 152; Viruses - 3; Other Eukaryotes - 97 (source: NCBI BLink).
    NP_850529.1
    • UDP-Glycosyltransferase superfamily protein; FUNCTIONS IN: transferase activity, transferring glycosyl groups; INVOLVED IN: lipid glycosylation, carbohydrate metabolic process, metabolic process; LOCATED IN: plasma membrane, membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Glycosyl transferase, family 28 (InterPro:IPR004276), UDP-glucuronosyl/UDP-glucosyltransferase (InterPro:IPR002213); BEST Arabidopsis thaliana protein match is: UDP-Glycosyltransferase superfamily protein (TAIR:AT1G43620.3); Has 2447 Blast hits to 2409 proteins in 631 species: Archae - 0; Bacteria - 1513; Metazoa - 298; Fungi - 386; Plants - 150; Viruses - 3; Other Eukaryotes - 97 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      2217622..2221956 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_180198.3 → NP_850529.1  UDP-Glycosyltransferase superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850529.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2EMW6, W8PUV4
      Conserved Domains (2) summary
      cd03784
      Location:193 → 609
      GT1_Gtf_like; This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the ...
      COG1819
      Location:192 → 609
      YjiC; UDP:flavonoid glycosyltransferase YjiC, YdhE family [Carbohydrate transport and metabolism]

    2. NM_111582.3 → NP_566297.2  UDP-Glycosyltransferase superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566297.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DFL3, O23649, Q93ZJ2, Q9M8Z7
      UniProtKB/TrEMBL
      A0A178VKP8, A0A5S9X9Y6
      Conserved Domains (2) summary
      cd03784
      Location:193 → 609
      GT1_Gtf_like; This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the ...
      COG1819
      Location:192 → 609
      YjiC; UDP:flavonoid glycosyltransferase YjiC, YdhE family [Carbohydrate transport and metabolism]

    3. NM_001337686.1 → NP_001326118.1  UDP-Glycosyltransferase superfamily protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VKP8, A0A1I9LNA9, A0A5S9X9Y6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9M8Z7.1

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