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    GIP1 GBF-interacting protein 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820513, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GIP1
    Official Full Name
    GBF-interacting protein 1
    Primary source
    TAIR:AT3G13222
    Locus tag
    AT3G13222
    See related
    Araport:AT3G13222
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    GBF-interacting protein 1
    Summary
    Encodes a protein that binds to G-box binding transcription factors and enhances their binding affinities to G-box in vitro. This protein localizes to the nucleus and is expressed predominantly in the root.
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    Genomic context

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    See GIP1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    9
    Sequence:
    Chromosome: 3; NC_003074.8 (4250958..4254278, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene crooked neck protein, putative / cell cycle protein Neighboring gene ABC-2 type transporter family protein Neighboring gene tRNA-Leu Neighboring gene RNA-binding (RRM/RBD/RNP motifs) family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of GIP1, an Arabidopsis thaliana protein that enhances the DNA binding affinity and reduces the oligomeric state of G-box binding factors. Sehnke PC, et al. Cell Res, 2005 Aug. PMID 16117846
    2. MGO3 and GIP1 act synergistically for the maintenance of centromeric cohesion. Batzenschlager M, et al. Nucleus, 2017 Jan 2. PMID 28033038, Free PMC Article
    3. GIP1 may act as a coactivator that enhances transcriptional activity of LBD18 in Arabidopsis. Lee HW, et al. J Plant Physiol, 2014 Mar 1. PMID 24484953
    4. Arabidopsis MZT1 homologs GIP1 and GIP2 are essential for centromere architecture. Batzenschlager M, et al. Proc Natl Acad Sci U S A, 2015 Jul 14. PMID 26124146, Free PMC Article
    5. GIP1 protein is a novel cofactor that regulates DNA-binding affinity of redox-regulated members of bZIP transcription factors involved in the early stages of Arabidopsis development. Shaikhali J. Protoplasma, 2015 May. PMID 25387999

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the contribution of both MGO3 and GIP1 to the regulation of centromeric cohesion in Arabidopsis
      Title: MGO3 and GIP1 act synergistically for the maintenance of centromeric cohesion.
    2. GIP1 functions to promote hypocotyl elongation during the early stages of Arabidopsis seedling development.
      Title: GIP1 protein is a novel cofactor that regulates DNA-binding affinity of redox-regulated members of bZIP transcription factors involved in the early stages of Arabidopsis development.
    3. ascribe a central function to GIPs for the proper recruitment and/or stabilization of centromeric proteins essential in the specification of the centromere identity, as well as for centromeric cohesion in somatic cells
      Title: Arabidopsis MZT1 homologs GIP1 and GIP2 are essential for centromere architecture.
    4. GBF INTERACTING PROTEIN1 (GIP1) interacts with LBD18 in yeast and Arabidopsis protoplasts. Reverse-transcription-pcr analysis showed overlapping expression of GIP1 and LBD18 in roots, aerial parts, and rosette leaves of Arabidopsis.
      Title: GIP1 may act as a coactivator that enhances transcriptional activity of LBD18 in Arabidopsis.
    5. The possible role of this protein during the nucleation process is discussed
      Title: Identification of a novel small Arabidopsis protein interacting with gamma-tubulin complex protein 3.
    6. GIP1 functions to enhance GBF DNA binding activity by acting as a potent nuclear chaperone or crowbar, and potentially regulates the multimeric state of GBFs, thereby contributing to bZIP-mediated gene regulation.
      Title: Identification and characterization of GIP1, an Arabidopsis thaliana protein that enhances the DNA binding affinity and reduces the oligomeric state of G-box binding factors.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_112163.6

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables unfolded protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    GBF-interacting protein 1
    NP_187929.4
    • GBF-interacting protein 1 (GIP1); CONTAINS InterPro DOMAIN/s: Protein of unknown function DUF1296 (InterPro:IPR009719); BEST Arabidopsis thaliana protein match is: Kinase-related protein of unknown function (DUF1296) (TAIR:AT1G55820.1); Has 232 Blast hits to 194 proteins in 50 species: Archae - 0; Bacteria - 13; Metazoa - 29; Fungi - 32; Plants - 145; Viruses - 0; Other Eukaryotes - 13 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      4250958..4254278 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_112163.6 → NP_187929.4  GBF-interacting protein 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_187929.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q84U77, Q8VZS6, Q9LK49
      UniProtKB/TrEMBL
      A0A178VMU4, A0A5S9XBM4
      Conserved Domains (1) summary
      pfam06972
      Location:14 → 74
      DUF1296; Protein of unknown function (DUF1296)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VZS6.1

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