U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CYP78A5 cytochrome P450, family 78, subfamily A, polypeptide 5 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837932, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    CYP78A5
    Official Full Name
    cytochrome P450, family 78, subfamily A, polypeptide 5
    Primary source
    TAIR:AT1G13710
    Locus tag
    AT1G13710
    See related
    Araport:AT1G13710
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ''cytochrome P450; cytochrome P450; F21F23.15; F21F23_15; family 78; KLU; KLUH; polypeptide 5; polypeptide 5''; subfamily A
    Summary
    Encodes the cytochrome P450 CYP78A5 monooxygenase. Contributes to the generation of a growth-stimulating signal distinct from the classical phytohormones that prevents proliferation arrest, promoting organ growth.
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See CYP78A5 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    2
    Sequence:
    Chromosome: 1; NC_003070.9 (4702657..4704694, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene 6-phosphogluconolactonase 1 Neighboring gene ncRNA Neighboring gene tRNA-Thr Neighboring gene Nuclear transport factor 2 (NTF2) family protein with RNA binding (RRM-RBD-RNP motifs) domain-containing protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Multi-omics approach reveals the contribution of KLU to leaf longevity and drought tolerance. Jiang L, et al. Plant Physiol, 2021 Mar 15. PMID 33721894, Free PMC Article
    2. KLUH/CYP78A5 promotes organ growth without affecting the size of the early primordium. Stransfeld L, et al. Plant Signal Behav, 2010 Aug. PMID 20657185, Free PMC Article
    3. The mechanism of cell cycle arrest front progression explained by a KLUH/CYP78A5-dependent mobile growth factor in developing leaves of Arabidopsis thaliana. Kazama T, et al. Plant Cell Physiol, 2010 Jun. PMID 20395288
    4. KLUH/CYP78A5-dependent growth signaling coordinates floral organ growth in Arabidopsis. Eriksson S, et al. Curr Biol, 2010 Mar 23. PMID 20188559
    5. Control of plant organ size by KLUH/CYP78A5-dependent intercellular signaling. Anastasiou E, et al. Dev Cell, 2007 Dec. PMID 18061566

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Multi-omics approach reveals the contribution of KLU to leaf longevity and drought tolerance.
      Title: Multi-omics approach reveals the contribution of KLU to leaf longevity and drought tolerance.
    2. AMP1 and CYP78A5/7 act through a common pathway to govern cell fate maintenance in Arabidopsis thaliana.
      Title: AMP1 and CYP78A5/7 act through a common pathway to govern cell fate maintenance in Arabidopsis thaliana.
    3. we show that CUC2 acts as a trigger to promote growth through the activation of three functional relays. In particular, we show that KLUH acts downstream of CUC2 to modulate auxin response and that expressing KLUH can compensate for deficient CUC2 expression during tooth growth.
      Title: Dissecting the pathways coordinating patterning and growth by plant boundary domains.
    4. These findings show how somatic cells in ovule primordia cooperatively use chromatin remodeling to restrict germ-line cell specification to a single cell.
      Title: KLU suppresses megasporocyte cell fate through SWR1-mediated activation of WRKY28 expression in Arabidopsis.
    5. KLU is required for chromosome pairing and organization at female meiosis I.KLU is required for normal DMC1 expression pattern in ovules undergoing megasporogenesis.
      Title: Comparative expression profiling reveals gene functions in female meiosis and gametophyte development in Arabidopsis.
    6. the genetic and molecular mechanisms of SOD7, DPA4, and KLU in seed size regulation, are reported.
      Title: Transcription factors SOD7/NGAL2 and DPA4/NGAL3 act redundantly to regulate seed size by directly repressing KLU expression in Arabidopsis thaliana.
    7. The overall activity level of KLU is integrated across an inflorescence to determine individual organ size, and growth is coordinated by a mobile KLU-dependent growth signal.
      Title: KLUH/CYP78A5 promotes organ growth without affecting the size of the early primordium.
    8. KLU generated a mobile growth factor gradient field in leaves.
      Title: The mechanism of cell cycle arrest front progression explained by a KLUH/CYP78A5-dependent mobile growth factor in developing leaves of Arabidopsis thaliana.
    9. the KLUH-dependent signal appears to move beyond individual organs in a flower, providing a mechanism for coordinating their growth and ensuring floral symmetry as an important determinant of a plant's attractiveness to pollinators
      Title: KLUH/CYP78A5-dependent growth signaling coordinates floral organ growth in Arabidopsis.
    10. Inactivation of CYP78A5, which is expressed at the periphery of the shoot apical meristem, accelerates the leaf initiation rate, whereas cyp78a5 cyp78a7 double mutants often die as embryos with supernumerary cotyledon primordia.
      Title: Dual effects of miR156-targeted SPL genes and CYP78A5/KLUH on plastochron length and organ size in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help
    NM_101240.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within floral organ development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within leaf formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within organ growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of organ growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of growth rate IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of meristem growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    cytochrome P450, family 78, subfamily A, polypeptide 5
    NP_172827.1
    • ''cytochrome P450, family 78, subfamily A, polypeptide 5'' (CYP78A5); FUNCTIONS IN: electron carrier activity, monooxygenase activity, iron ion binding, oxygen binding, heme binding; INVOLVED IN: in 7 processes; LOCATED IN: endoplasmic reticulum; EXPRESSED IN: 10 plant structures; EXPRESSED DURING: F mature embryo stage, petal differentiation and expansion stage, E expanded cotyledon stage, D bilateral stage; CONTAINS InterPro DOMAIN/s: Cytochrome P450 (InterPro:IPR001128), Cytochrome P450, E-class, group I (InterPro:IPR002401), Cytochrome P450, conserved site (InterPro:IPR017972); BEST Arabidopsis thaliana protein match is: cytochrome P450, family 78, subfamily A, polypeptide 10 (TAIR:AT1G74110.1); Has 31179 Blast hits to 31066 proteins in 1571 species: Archae - 49; Bacteria - 2905; Metazoa - 11364; Fungi - 6716; Plants - 9120; Viruses - 3; Other Eukaryotes - 1022 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      4702657..4704694 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_101240.4 → NP_172827.1  cytochrome P450, family 78, subfamily A, polypeptide 5 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_172827.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LMX7
      UniProtKB/TrEMBL
      A0A178WF71, A0A5S9UAP0, A0A654EAM2
      Conserved Domains (1) summary
      cd11076
      Location:81 → 505
      CYP78; cytochrome P450 family 78
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LMX7.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools