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    ZYP1b Myosin heavy chain-related protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 838834, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ZYP1b
    Official Full Name
    Myosin heavy chain-related protein
    Primary source
    TAIR:AT1G22275
    Locus tag
    AT1G22275
    See related
    Araport:AT1G22275
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ZYP1
    Summary
    One of two nearly identical proteins (ZYP1a) identified by similarity to transverse filament (TF) proteins. These proteins are involved in chromosome synapsis during meiosis I and localize to the synaptonemal complex (SC). Single mutants have reduced fertility and double mutants (induced by RNAi) have severely reduced fertility.
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    Genomic context

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    See ZYP1b in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    19
    Sequence:
    Chromosome: 1; NC_003070.9 (7867067..7872715)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Myosin heavy chain-related protein Neighboring gene Trm112p-like protein Neighboring gene ncRNA Neighboring gene phytochrome-associated protein phosphatase type 2C

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ZYP1 is required for obligate cross-over formation and cross-over interference in Arabidopsis. France MG, et al. Proc Natl Acad Sci U S A, 2021 Apr 6. PMID 33782125, Free PMC Article
    2. The Arabidopsis synaptonemal complex protein ZYP1 is required for chromosome synapsis and normal fidelity of crossing over. Higgins JD, et al. Genes Dev, 2005 Oct 15. PMID 16230536, Free PMC Article
    3. ZYP1-mediated recruitment of PCH2 to the synaptonemal complex remodels the chromosome axis leading to crossover restriction. Yang C, et al. Nucleic Acids Res, 2022 Dec 9. PMID 36504011, Free PMC Article
    4. Proteomic profiling of tandem affinity purified 14-3-3 protein complexes in Arabidopsis thaliana. Chang IF, et al. Proteomics, 2009 Jun. PMID 19452453, Free PMC Article
    5. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZYP1-mediated recruitment of PCH2 to the synaptonemal complex remodels the chromosome axis leading to crossover restriction.
      Title: ZYP1-mediated recruitment of PCH2 to the synaptonemal complex remodels the chromosome axis leading to crossover restriction.
    2. ZYP1 is required for obligate cross-over formation and cross-over interference in Arabidopsis.
      Title: ZYP1 is required for obligate cross-over formation and cross-over interference in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables molecular adaptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within homologous chromosome pairing at meiosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within reciprocal meiotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within synaptonemal complex assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in synaptonemal complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Myosin heavy chain-related protein
    NP_564164.1
    • ZYP1b; BEST Arabidopsis thaliana protein match is: Myosin heavy chain-related protein (TAIR:AT1G22260.1); Has 145563 Blast hits to 75800 proteins in 3137 species: Archae - 2001; Bacteria - 27401; Metazoa - 61286; Fungi - 11195; Plants - 7048; Viruses - 666; Other Eukaryotes - 35966 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      7867067..7872715
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_102078.3 → NP_564164.1  Myosin heavy chain-related protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564164.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P61430, Q4TWG1, Q9LME3
      UniProtKB/TrEMBL
      A0A654EDZ9
      Conserved Domains (2) summary
      COG1196
      Location:332 → 665
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:48 → 718
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    2. NM_001332545.1 → NP_001323354.1  Myosin heavy chain-related protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AWY4, A0A654EDZ9

    3. NM_001332546.1 → NP_001323355.1  Myosin heavy chain-related protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AWS1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P61430.1

    Gene LinkOut

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