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    AMP-dependent synthetase and ligase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 825864, updated on 18-Sep-2024

    Summary

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    Official Full Name
    AMP-dependent synthetase and ligase family protein
    Primary source
    TAIR:AT4G05160
    Locus tag
    AT4G05160
    See related
    Araport:AT4G05160
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    C17L7.80; C17L7_80
    Summary
    Encodes a peroxisomal protein involved in the activation of fatty acids through esterification with CoA. At4g05160 preferentially activates fatty acids with medium chain length (C6:0 and C7:0) as well as even-numbered long-chain fatty acids (C14:0, C16:0 and C18:0). At4g05160 was also able to catalyze the conversion of OPC-6:0 to its CoA ester and is therefore thought to be involved in the peroxisomal beta-oxidation steps of jasmonic acid biosynthesis.
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    Genomic context

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    Location:
    chromosome: 4
    Exon count:
    6
    Sequence:
    Chromosome: 4; NC_003075.7 (2664314..2666973)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Octicosapeptide/Phox/Bem1p family protein Neighboring gene basic helix-loop-helix (bHLH) DNA-binding superfamily protein Neighboring gene photosystem II subunit Q-2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new type of peroxisomal acyl-coenzyme A synthetase from Arabidopsis thaliana has the catalytic capacity to activate biosynthetic precursors of jasmonic acid. Schneider K, et al. J Biol Chem, 2005 Apr 8. PMID 15677481
    2. Jasmonates meet fatty acids: functional analysis of a new acyl-coenzyme A synthetase family from Arabidopsis thaliana. Kienow L, et al. J Exp Bot, 2008. PMID 18267944
    3. Proteome analysis of Arabidopsis leaf peroxisomes reveals novel targeting peptides, metabolic pathways, and defense mechanisms. Reumann S, et al. Plant Cell, 2007 Oct. PMID 17951448, Free PMC Article
    4. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data demonstrate that At4g05160 and At5g63380 have the capacity to contribute to jasmonic acid biosynthesis by initiating the beta-oxidative chain shortening of its precursors.
      Title: A new type of peroxisomal acyl-coenzyme A synthetase from Arabidopsis thaliana has the catalytic capacity to activate biosynthetic precursors of jasmonic acid.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    NM_116755.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 4-coumarate-CoA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables fatty-acyl-CoA synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    NOT involved_in auxin biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT involved_in auxin metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within jasmonic acid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT involved_in response to bacterium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT involved_in response to wounding IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  
    located_in peroxisome HDA PubMed 
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    AMP-dependent synthetase and ligase family protein
    NP_192425.1
    • AMP-dependent synthetase and ligase family protein; FUNCTIONS IN: 4-coumarate-CoA ligase activity, fatty-acyl-CoA synthase activity; INVOLVED IN: jasmonic acid biosynthetic process; LOCATED IN: peroxisome; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: AMP-binding, conserved site (InterPro:IPR020845), AMP-dependent synthetase/ligase (InterPro:IPR000873); BEST Arabidopsis thaliana protein match is: OPC-8:0 CoA ligase1 (TAIR:AT1G20510.1); Has 86858 Blast hits to 79133 proteins in 3797 species: Archae - 1159; Bacteria - 54259; Metazoa - 3570; Fungi - 4802; Plants - 2877; Viruses - 1; Other Eukaryotes - 20190 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      2664314..2666973
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_116755.5 → NP_192425.1  AMP-dependent synthetase and ligase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_192425.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9M0X9
      UniProtKB/TrEMBL
      A0A178UXS2, A0A5S9XQ10, A0A654FLR8
      Conserved Domains (1) summary
      cd05904
      Location:21 → 536
      4CL; 4-Coumarate-CoA Ligase (4CL)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9M0X9.1

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