NmrA-like negative transcriptional regulator family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Full Name: NmrA-like negative transcriptional regulator family protein
Primary source: TAIR:AT4G39230
Locus tag: AT4G39230
See related: Araport:AT4G39230
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: T22F8.130; T22F8_130
Summary: encodes a protein whose sequence is similar to phenylcoumaran benzylic ether reductase (PCBER), which catalyzes NADPH-dependent reduction of 8-5' linked lignans such as dehydrodiconiferyl alcohol to give isodihydrodehydrodiconiferyl alcohol.
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Genomic context

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See in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 5

Sequence:: Chromosome: 4; NC_003075.7 (18265735..18267829, complement)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate that At4g39230, designated AtPCBER1, encodes a polypeptide with benzylic ether reductase (PCBER) activity and has a critical role in the biosynthesis of secondary metabolites.
Title: Expression and functional analyses of a putative phenylcoumaran benzylic ether reductase in Arabidopsis thaliana.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_120083.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor	IDA Inferred from Direct Assay more info	PubMed
enables phenylcoumaran benzylic ether reductase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in lignan biosynthetic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: NmrA-like negative transcriptional regulator family protein

NP_195634.1

NmrA-like negative transcriptional regulator family protein; FUNCTIONS IN: phenylcoumaran benzylic ether reductase activity; INVOLVED IN: response to cadmium ion; LOCATED IN: cellular_component unknown; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: NAD(P)-binding domain (InterPro:IPR016040), NmrA-like (InterPro:IPR008030); BEST Arabidopsis thaliana protein match is: NmrA-like negative transcriptional regulator family protein (TAIR:AT1G75280.1); Has 1665 Blast hits to 1661 proteins in 371 species: Archae - 16; Bacteria - 474; Metazoa - 2; Fungi - 521; Plants - 522; Viruses - 3; Other Eukaryotes - 127 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

18265735..18267829 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_120083.5 → NP_195634.1 NmrA-like negative transcriptional regulator family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_195634.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8RXS0, Q9T030

UniProtKB/TrEMBL

A0A178V352, A0A5S9Y0N1, A0A7G2F749

Conserved Domains (1) summary

pfam05368
Location:7 → 237

NmrA; NmrA-like family