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    NCOR2 nuclear receptor corepressor 2 [ Homo sapiens (human) ]

    Gene ID: 9612, updated on 9-Dec-2024

    Summary

    Official Symbol
    NCOR2provided by HGNC
    Official Full Name
    nuclear receptor corepressor 2provided by HGNC
    Primary source
    HGNC:HGNC:7673
    See related
    Ensembl:ENSG00000196498 MIM:600848; AllianceGenome:HGNC:7673
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SMRT; TRAC; CTG26; SMRTE; TRAC1; N-CoR2; TNRC14; TRAC-1; SMAP270; SMRTE-tau
    Summary
    This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes. Aberrant expression of this gene is associated with certain cancers. Alternate splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Apr 2011]
    Expression
    Ubiquitous expression in fat (RPKM 14.9), lung (RPKM 14.3) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See NCOR2 in Genome Data Viewer
    Location:
    12q24.31
    Exon count:
    49
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (124324415..124567612, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (124326823..124572906, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (124808961..125052158, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:124456863-124457600 Neighboring gene ZNF664-RFLNA readthrough Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5053 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5054 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5055 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7276 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5056 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7277 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7278 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7279 Neighboring gene zinc finger protein 664 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr12:124556312-124557118 Neighboring gene NANOG hESC enhancer GRCh37_chr12:124594949-124595450 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:124600014-124600560 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:124601106-124601651 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:124601652-124602196 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:124608857-124609358 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr12:124624781-124625523 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:124625524-124626265 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:124630091-124630857 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:124666563-124667068 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:124672143-124672663 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:124672664-124673183 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:124673184-124673704 Neighboring gene Sharpr-MPRA regulatory region 13038 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:124725860-124726762 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7280 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:124786919-124787420 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:124801665-124802264 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7281 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7282 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7283 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:124821000-124821180 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:124828658-124829158 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:124829159-124829659 Neighboring gene Sharpr-MPRA regulatory region 3491 Neighboring gene refilin A Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:124853631-124854132 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:124866685-124867231 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:124866136-124866684 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:124868677-124869413 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:124869414-124870149 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:124870150-124870886 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:124870887-124871621 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5057 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7284 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:124876499-124877188 Neighboring gene microRNA 6880 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:124879259-124879948 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:124879949-124880636 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:124883733-124884232 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:124887188-124887832 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:124887833-124888476 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:124896741-124897368 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:124897369-124897997 Neighboring gene Sharpr-MPRA regulatory region 11802 Neighboring gene uncharacterized LOC124903044 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:124911835-124912374 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:124912375-124912913 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:124917115-124917722 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:124917723-124918330 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7285 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:124924007-124924726 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:124924727-124925447 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:124937508-124938346 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5058 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5059 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:124947144-124947710 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:124947711-124948278 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7287 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5060 Neighboring gene conserved acetylation island sequence 32 enhancer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:124963398-124963907 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:124964417-124964926 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:124964927-124965434 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7288 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7289 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:124975405-124975905 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:124979536-124980495 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:124980496-124981454 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr12:124988989-124990188 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:124992013-124992598 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:124992911-124993125 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:124993187-124993772 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:124996849-124997397 Neighboring gene uncharacterized LOC105370047 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:124997398-124997946 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:125005559-125006111 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125012056-125013044 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125016945-125017877 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125024060-125024769 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125026984-125027517 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125028586-125029120 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7292 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125035807-125036625 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:125040245-125041002 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:125042521-125043280 Neighboring gene Sharpr-MPRA regulatory region 1212 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7293 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5065 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5064 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5062 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5063 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5061 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125052750-125053610 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125053611-125054471 Neighboring gene Sharpr-MPRA regulatory region 12812 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:125077891-125078394 Neighboring gene uncharacterized LOC101927436 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7294 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:125106212-125107104 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:125107105-125107998 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:125117605-125118804 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:125120143-125120783 Neighboring gene Sharpr-MPRA regulatory region 4504 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125130641-125131250 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:125136287-125136800 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:125136801-125137314 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_25120 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:125158286-125158903 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:125160065-125160662 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125161261-125161858 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7296 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7297 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125169354-125169898 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125169899-125170441 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125172481-125173202 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:125179365-125179866 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125197387-125198032 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125198033-125198677 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125215664-125216268 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125216269-125216872 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:125218412-125219186 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:125219187-125219961 Neighboring gene uncharacterized LOC124903045

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB.
    EBI GWAS Catalog
    Genome-wide association study identifies new disease loci for isolated clubfoot.
    EBI GWAS Catalog
    Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan.
    EBI GWAS Catalog
    Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of nuclear receptor corepressor 2 (NCOR2) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ25011

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables Notch binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables chromatin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables enzyme activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone deacetylase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables nuclear glucocorticoid receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nuclear retinoid X receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription corepressor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane HDA PubMed 
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IC
    Inferred by Curator
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of transcription repressor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    nuclear receptor corepressor 2
    Names
    CTG repeat protein 26
    T3 receptor-associating factor
    silencing mediator for retinoid and thyroid hormone receptors
    thyroid-, retinoic-acid-receptor-associated corepressor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_022928.2 RefSeqGene

      Range
      4853..248050
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001077261.4NP_001070729.2  nuclear receptor corepressor 2 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has multiple difference in the coding region, but maintains the reading frame, compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter than isoform 1.
      Source sequence(s)
      AC069261, AC073592, AC073916
      Consensus CDS
      CCDS41857.2
      UniProtKB/TrEMBL
      C9JE98
      Related
      ENSP00000384202.1, ENST00000404621.5
      Conserved Domains (4) summary
      smart00717
      Location:613658
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam00249
      Location:613656
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam15784
      Location:142228
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
      cl21498
      Location:431474
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    2. NM_001206654.2NP_001193583.1  nuclear receptor corepressor 2 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has multiple difference in the coding region, but maintains the reading frame, compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter than isoform 1.
      Source sequence(s)
      AC069261, AC073592, AC073916
      Consensus CDS
      CCDS55892.1
      UniProtKB/TrEMBL
      C9J0Q5
      Related
      ENSP00000400281.2, ENST00000429285.6
      Conserved Domains (4) summary
      smart00717
      Location:613658
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam00249
      Location:613656
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam15784
      Location:142228
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
      cl21498
      Location:431474
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    3. NM_006312.6NP_006303.4  nuclear receptor corepressor 2 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC069261, AC073592, AC073916
      Consensus CDS
      CCDS41858.2
      UniProtKB/Swiss-Prot
      O00613, O15416, O15421, Q13354, Q56D06, Q59GM0, Q9Y5U0, Q9Y618
      Related
      ENSP00000384018.1, ENST00000405201.6
      Conserved Domains (6) summary
      pfam00249
      Location:614657
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam15784
      Location:142228
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
      cl21498
      Location:432475
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      cl25732
      Location:100458
      SMC_N; RecF/RecN/SMC N terminal domain
      cl26464
      Location:9091192
      Atrophin-1; Atrophin-1 family
      cl27154
      Location:541649
      SWIRM; SWIRM domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      124324415..124567612 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      124326823..124572906 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)