NEW
Try the new Transcript table
These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_023295.2Â RefSeqGene
- Range
-
4976..326820
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
NM_198834.3 → NP_942131.1  acetyl-CoA carboxylase 1 isoform 1
See identical proteins and their annotated locations for NP_942131.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) encodes the longest isoform (1).
- Source sequence(s)
-
AB371587, AC243654, AY315625, BC041598, CF454424
- Consensus CDS
-
CCDS42302.1
- UniProtKB/TrEMBL
-
A2NX49
- Related
- ENSP00000483300.1, ENST00000616317.5
- Conserved Domains (8) summary
-
- COG0439
Location:155 → 657
- AccC; Biotin carboxylase [Lipid transport and metabolism]
- COG0511
Location:708 → 855
- AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
- pfam00289
Location:155 → 274
- CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
- pfam00364
Location:790 → 855
- Biotin_lipoyl; Biotin-requiring enzyme
- pfam01039
Location:1706 → 2254
- Carboxyl_trans; Carboxyl transferase domain
- pfam02785
Location:544 → 651
- Biotin_carb_C; Biotin carboxylase C-terminal domain
- pfam08326
Location:857 → 1606
- ACC_central; Acetyl-CoA carboxylase, central region
- cl17255
Location:316 → 507
- ATP-grasp_4; ATP-grasp domain
-
NM_198836.3 → NP_942133.1  acetyl-CoA carboxylase 1 isoform 2
See identical proteins and their annotated locations for NP_942133.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (3) has an alternate 5' UTR exon, and uses a downstream start codon, as compared to variant (1). The resulting isoform (2) has a shorter N-terminus, as compared to isoform 1.
- Source sequence(s)
-
AB371587, AY315621, BC041598
- Consensus CDS
-
CCDS11317.1
- UniProtKB/Swiss-Prot
- B2RP68, B2ZZ90, Q13085, Q6KEV6, Q6XDA8, Q7Z2G8, Q7Z561, Q7Z563, Q7Z564, Q86WB2, Q86WB3
- UniProtKB/TrEMBL
-
A2NX49
- Related
- ENSP00000478547.1, ENST00000614428.4
- Conserved Domains (5) summary
-
- COG0439
Location:118 → 620
- AccC; Biotin carboxylase [Lipid transport and metabolism]
- COG0511
Location:671 → 818
- AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
- pfam00364
Location:754 → 818
- Biotin_lipoyl; Biotin-requiring enzyme
- pfam01039
Location:1669 → 2217
- Carboxyl_trans; Carboxyl transferase domain
- pfam08326
Location:820 → 1569
- ACC_central; Acetyl-CoA carboxylase, central region
-
NM_198837.2 → NP_942134.1  acetyl-CoA carboxylase 1 isoform 3
See identical proteins and their annotated locations for NP_942134.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (4) has a shorter and alternate 5' sequence, as compared to variant 1. The resulting isoform (3) has a distinct and shorter N-terminus, as compared to isoform 1.
- Source sequence(s)
-
AY315620, AY315627, BC031485, BC041598, U19822
- Consensus CDS
-
CCDS11318.1
- UniProtKB/TrEMBL
-
A2NX49
- Related
- ENSP00000482269.1, ENST00000612895.4
- Conserved Domains (8) summary
-
- COG0439
Location:60 → 562
- AccC; Biotin carboxylase [Lipid transport and metabolism]
- COG0511
Location:613 → 760
- AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
- pfam00289
Location:60 → 179
- CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
- pfam00364
Location:695 → 760
- Biotin_lipoyl; Biotin-requiring enzyme
- pfam01039
Location:1611 → 2159
- Carboxyl_trans; Carboxyl transferase domain
- pfam02785
Location:449 → 556
- Biotin_carb_C; Biotin carboxylase C-terminal domain
- pfam08326
Location:762 → 1511
- ACC_central; Acetyl-CoA carboxylase, central region
- cl17255
Location:221 → 412
- ATP-grasp_4; ATP-grasp domain
-
NM_198838.2 → NP_942135.1  acetyl-CoA carboxylase 1 isoform 4
See identical proteins and their annotated locations for NP_942135.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (5) has a shorter and alternate 5' sequence and uses a downstream start codon, as compared to variant 1. The resulting isoform (4) has a shorter N-terminus, as compared to isoform 1.
- Source sequence(s)
-
AY315619, AY315627, BC031485, BC041598, U19822
- Consensus CDS
-
CCDS42303.1
- UniProtKB/TrEMBL
-
A2NX49
- Related
- ENSP00000482368.1, ENST00000617649.4
- Conserved Domains (8) summary
-
- COG0439
Location:40 → 542
- AccC; Biotin carboxylase [Lipid transport and metabolism]
- COG0511
Location:593 → 740
- AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
- pfam00289
Location:40 → 159
- CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
- pfam00364
Location:675 → 740
- Biotin_lipoyl; Biotin-requiring enzyme
- pfam01039
Location:1591 → 2139
- Carboxyl_trans; Carboxyl transferase domain
- pfam02785
Location:429 → 536
- Biotin_carb_C; Biotin carboxylase C-terminal domain
- pfam08326
Location:742 → 1491
- ACC_central; Acetyl-CoA carboxylase, central region
- cl17255
Location:201 → 392
- ATP-grasp_4; ATP-grasp domain
-
NM_198839.3 → NP_942136.1  acetyl-CoA carboxylase 1 isoform 2
See identical proteins and their annotated locations for NP_942136.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) is the longest transcript, which has several additional exons in the 5' region, as compared to variant 1. It uses a downstream start codon and the resulting isoform (2) has a shorter N-terminus, as compared to isoform 1.
- Source sequence(s)
-
AB371587, AC243654, AY315623, BC041598, CF454424
- Consensus CDS
-
CCDS11317.1
- UniProtKB/Swiss-Prot
- B2RP68, B2ZZ90, Q13085, Q6KEV6, Q6XDA8, Q7Z2G8, Q7Z561, Q7Z563, Q7Z564, Q86WB2, Q86WB3
- UniProtKB/TrEMBL
-
A2NX49
- Conserved Domains (5) summary
-
- COG0439
Location:118 → 620
- AccC; Biotin carboxylase [Lipid transport and metabolism]
- COG0511
Location:671 → 818
- AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
- pfam00364
Location:754 → 818
- Biotin_lipoyl; Biotin-requiring enzyme
- pfam01039
Location:1669 → 2217
- Carboxyl_trans; Carboxyl transferase domain
- pfam08326
Location:820 → 1569
- ACC_central; Acetyl-CoA carboxylase, central region
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000017.11Â Reference GRCh38.p14 Primary Assembly
- Range
-
37084992..37406836 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_011524701.2 → XP_011523003.1  acetyl-CoA carboxylase 1 isoform X2
See identical proteins and their annotated locations for XP_011523003.1
- UniProtKB/TrEMBL
-
A2NX49
- Conserved Domains (8) summary
-
- COG0439
Location:125 → 627
- AccC; Biotin carboxylase [Lipid transport and metabolism]
- COG0511
Location:678 → 825
- AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
- pfam00289
Location:125 → 244
- CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
- pfam00364
Location:760 → 825
- Biotin_lipoyl; Biotin-requiring enzyme
- pfam01039
Location:1676 → 2224
- Carboxyl_trans; Carboxyl transferase domain
- pfam02785
Location:514 → 621
- Biotin_carb_C; Biotin carboxylase C-terminal domain
- pfam08326
Location:827 → 1576
- ACC_central; Acetyl-CoA carboxylase, central region
- cl17255
Location:286 → 477
- ATP-grasp_4; ATP-grasp domain
-
XM_006721853.2 → XP_006721916.1  acetyl-CoA carboxylase 1 isoform X1
- UniProtKB/TrEMBL
-
A2NX49
- Conserved Domains (8) summary
-
- COG0439
Location:155 → 657
- AccC; Biotin carboxylase [Lipid transport and metabolism]
- COG0511
Location:708 → 855
- AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
- pfam00289
Location:155 → 274
- CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
- pfam00364
Location:790 → 855
- Biotin_lipoyl; Biotin-requiring enzyme
- pfam01039
Location:1698 → 2246
- Carboxyl_trans; Carboxyl transferase domain
- pfam02785
Location:544 → 651
- Biotin_carb_C; Biotin carboxylase C-terminal domain
- pfam08326
Location:857 → 1598
- ACC_central; Acetyl-CoA carboxylase, central region
- cl17255
Location:316 → 507
- ATP-grasp_4; ATP-grasp domain
-
XM_047435882.1 → XP_047291838.1  acetyl-CoA carboxylase 1 isoform X3
- UniProtKB/Swiss-Prot
- B2RP68, B2ZZ90, Q13085, Q6KEV6, Q6XDA8, Q7Z2G8, Q7Z561, Q7Z563, Q7Z564, Q86WB2, Q86WB3
- UniProtKB/TrEMBL
-
A2NX49
-
XM_047435883.1 → XP_047291839.1  acetyl-CoA carboxylase 1 isoform X3
- UniProtKB/Swiss-Prot
- B2RP68, B2ZZ90, Q13085, Q6KEV6, Q6XDA8, Q7Z2G8, Q7Z561, Q7Z563, Q7Z564, Q86WB2, Q86WB3
- UniProtKB/TrEMBL
-
A2NX49
-
XM_047435881.1 → XP_047291837.1  acetyl-CoA carboxylase 1 isoform X3
- UniProtKB/Swiss-Prot
- B2RP68, B2ZZ90, Q13085, Q6KEV6, Q6XDA8, Q7Z2G8, Q7Z561, Q7Z563, Q7Z564, Q86WB2, Q86WB3
- UniProtKB/TrEMBL
-
A2NX49
-
XM_047435879.1 → XP_047291835.1  acetyl-CoA carboxylase 1 isoform X3
- UniProtKB/Swiss-Prot
- B2RP68, B2ZZ90, Q13085, Q6KEV6, Q6XDA8, Q7Z2G8, Q7Z561, Q7Z563, Q7Z564, Q86WB2, Q86WB3
- UniProtKB/TrEMBL
-
A2NX49
-
XM_047435880.1 → XP_047291836.1  acetyl-CoA carboxylase 1 isoform X3
- UniProtKB/Swiss-Prot
- B2RP68, B2ZZ90, Q13085, Q6KEV6, Q6XDA8, Q7Z2G8, Q7Z561, Q7Z563, Q7Z564, Q86WB2, Q86WB3
- UniProtKB/TrEMBL
-
A2NX49
-
XM_047435878.1 → XP_047291834.1  acetyl-CoA carboxylase 1 isoform X3
- UniProtKB/Swiss-Prot
- B2RP68, B2ZZ90, Q13085, Q6KEV6, Q6XDA8, Q7Z2G8, Q7Z561, Q7Z563, Q7Z564, Q86WB2, Q86WB3
- UniProtKB/TrEMBL
-
A2NX49
-
XM_047435892.1 → XP_047291848.1  acetyl-CoA carboxylase 1 isoform X7
- UniProtKB/TrEMBL
-
A2NX49
-
XM_005257267.6 → XP_005257324.1  acetyl-CoA carboxylase 1 isoform X6
See identical proteins and their annotated locations for XP_005257324.1
- UniProtKB/TrEMBL
-
A2NX49
- Conserved Domains (8) summary
-
- COG0439
Location:40 → 542
- AccC; Biotin carboxylase [Lipid transport and metabolism]
- COG0511
Location:593 → 740
- AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
- pfam00289
Location:40 → 159
- CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
- pfam00364
Location:675 → 740
- Biotin_lipoyl; Biotin-requiring enzyme
- pfam01039
Location:1591 → 2139
- Carboxyl_trans; Carboxyl transferase domain
- pfam02785
Location:429 → 536
- Biotin_carb_C; Biotin carboxylase C-terminal domain
- pfam08326
Location:742 → 1491
- ACC_central; Acetyl-CoA carboxylase, central region
- cl17255
Location:201 → 392
- ATP-grasp_4; ATP-grasp domain
-
XM_047435891.1 → XP_047291847.1  acetyl-CoA carboxylase 1 isoform X7
- UniProtKB/TrEMBL
-
A2NX49
-
XM_011524704.3 → XP_011523006.1  acetyl-CoA carboxylase 1 isoform X6
See identical proteins and their annotated locations for XP_011523006.1
- UniProtKB/TrEMBL
-
A2NX49
- Conserved Domains (8) summary
-
- COG0439
Location:40 → 542
- AccC; Biotin carboxylase [Lipid transport and metabolism]
- COG0511
Location:593 → 740
- AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
- pfam00289
Location:40 → 159
- CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
- pfam00364
Location:675 → 740
- Biotin_lipoyl; Biotin-requiring enzyme
- pfam01039
Location:1591 → 2139
- Carboxyl_trans; Carboxyl transferase domain
- pfam02785
Location:429 → 536
- Biotin_carb_C; Biotin carboxylase C-terminal domain
- pfam08326
Location:742 → 1491
- ACC_central; Acetyl-CoA carboxylase, central region
- cl17255
Location:201 → 392
- ATP-grasp_4; ATP-grasp domain
-
XM_047435884.1 → XP_047291840.1  acetyl-CoA carboxylase 1 isoform X4
- UniProtKB/TrEMBL
-
A2NX49
-
XM_047435893.1 → XP_047291849.1  acetyl-CoA carboxylase 1 isoform X7
- UniProtKB/TrEMBL
-
A2NX49
-
XM_047435890.1 → XP_047291846.1  acetyl-CoA carboxylase 1 isoform X6
- UniProtKB/TrEMBL
-
A2NX49
-
XM_047435885.1 → XP_047291841.1  acetyl-CoA carboxylase 1 isoform X4
- UniProtKB/TrEMBL
-
A2NX49
-
XM_011524703.1 → XP_011523005.1  acetyl-CoA carboxylase 1 isoform X3
See identical proteins and their annotated locations for XP_011523005.1
- UniProtKB/Swiss-Prot
- B2RP68, B2ZZ90, Q13085, Q6KEV6, Q6XDA8, Q7Z2G8, Q7Z561, Q7Z563, Q7Z564, Q86WB2, Q86WB3
- UniProtKB/TrEMBL
-
A2NX49
- Conserved Domains (5) summary
-
- COG0439
Location:118 → 620
- AccC; Biotin carboxylase [Lipid transport and metabolism]
- COG0511
Location:671 → 818
- AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
- pfam00364
Location:754 → 818
- Biotin_lipoyl; Biotin-requiring enzyme
- pfam01039
Location:1669 → 2217
- Carboxyl_trans; Carboxyl transferase domain
- pfam08326
Location:820 → 1569
- ACC_central; Acetyl-CoA carboxylase, central region
-
XM_047435888.1 → XP_047291844.1  acetyl-CoA carboxylase 1 isoform X5
- UniProtKB/TrEMBL
-
A2NX49
-
XM_047435886.1 → XP_047291842.1  acetyl-CoA carboxylase 1 isoform X8
- UniProtKB/TrEMBL
-
A2NX49
-
XM_047435889.1 → XP_047291845.1  acetyl-CoA carboxylase 1 isoform X5
- UniProtKB/TrEMBL
-
A2NX49
-
XM_047435894.1 → XP_047291850.1  acetyl-CoA carboxylase 1 isoform X9
Reference GRCh38.p14 ALT_REF_LOCI_1
Genomic
-
NT_187614.1Â Reference GRCh38.p14 ALT_REF_LOCI_1
- Range
-
1320992..1645992 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_054329294.1 → XP_054185269.1  acetyl-CoA carboxylase 1 isoform X6
- UniProtKB/TrEMBL
-
A2NX49
-
XM_054329286.1 → XP_054185261.1  acetyl-CoA carboxylase 1 isoform X2
- UniProtKB/TrEMBL
-
A2NX49
-
XM_054329285.1 → XP_054185260.1  acetyl-CoA carboxylase 1 isoform X1
- UniProtKB/TrEMBL
-
A2NX49
-
XM_054329287.1 → XP_054185262.1  acetyl-CoA carboxylase 1 isoform X3
- UniProtKB/Swiss-Prot
- B2RP68, B2ZZ90, Q13085, Q6KEV6, Q6XDA8, Q7Z2G8, Q7Z561, Q7Z563, Q7Z564, Q86WB2, Q86WB3
- UniProtKB/TrEMBL
-
A2NX49
-
XM_054329296.1 → XP_054185271.1  acetyl-CoA carboxylase 1 isoform X3
- UniProtKB/Swiss-Prot
- B2RP68, B2ZZ90, Q13085, Q6KEV6, Q6XDA8, Q7Z2G8, Q7Z561, Q7Z563, Q7Z564, Q86WB2, Q86WB3
- UniProtKB/TrEMBL
-
A2NX49
-
XM_054329288.1 → XP_054185263.1  acetyl-CoA carboxylase 1 isoform X4
- UniProtKB/TrEMBL
-
A2NX49
-
XM_054329295.1 → XP_054185270.1  acetyl-CoA carboxylase 1 isoform X7
- UniProtKB/TrEMBL
-
A2NX49
-
XM_054329292.1 → XP_054185267.1  acetyl-CoA carboxylase 1 isoform X6
- UniProtKB/TrEMBL
-
A2NX49
-
XM_054329293.1 → XP_054185268.1  acetyl-CoA carboxylase 1 isoform X6
- UniProtKB/TrEMBL
-
A2NX49
-
XM_054329289.1 → XP_054185264.1  acetyl-CoA carboxylase 1 isoform X4
- UniProtKB/TrEMBL
-
A2NX49
-
XM_054329291.1 → XP_054185266.1  acetyl-CoA carboxylase 1 isoform X5
- UniProtKB/TrEMBL
-
A2NX49
-
XM_054329290.1 → XP_054185265.1  acetyl-CoA carboxylase 1 isoform X5
- UniProtKB/TrEMBL
-
A2NX49
-
XM_054329297.1 → XP_054185272.1  acetyl-CoA carboxylase 1 isoform X10
Alternate T2T-CHM13v2.0
Genomic
-
NC_060941.1Â Alternate T2T-CHM13v2.0
- Range
-
38071975..38396996 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_054315907.1 → XP_054171882.1  acetyl-CoA carboxylase 1 isoform X6
- UniProtKB/TrEMBL
-
A2NX49
-
XM_054315898.1 → XP_054171873.1  acetyl-CoA carboxylase 1 isoform X2
- UniProtKB/TrEMBL
-
A2NX49
-
XM_054315897.1 → XP_054171872.1  acetyl-CoA carboxylase 1 isoform X1
- UniProtKB/TrEMBL
-
A2NX49
-
XM_054315896.1 → XP_054171871.1  acetyl-CoA carboxylase 1 isoform X12
- UniProtKB/TrEMBL
-
A2NX49
-
XM_054315895.1 → XP_054171870.1  acetyl-CoA carboxylase 1 isoform X11
- UniProtKB/TrEMBL
-
A2NX49
-
XM_054315899.1 → XP_054171874.1  acetyl-CoA carboxylase 1 isoform X3
- UniProtKB/Swiss-Prot
- B2RP68, B2ZZ90, Q13085, Q6KEV6, Q6XDA8, Q7Z2G8, Q7Z561, Q7Z563, Q7Z564, Q86WB2, Q86WB3
- UniProtKB/TrEMBL
-
A2NX49
-
XM_054315911.1 → XP_054171886.1  acetyl-CoA carboxylase 1 isoform X3
- UniProtKB/Swiss-Prot
- B2RP68, B2ZZ90, Q13085, Q6KEV6, Q6XDA8, Q7Z2G8, Q7Z561, Q7Z563, Q7Z564, Q86WB2, Q86WB3
- UniProtKB/TrEMBL
-
A2NX49
-
XM_054315901.1 → XP_054171876.1  acetyl-CoA carboxylase 1 isoform X4
- UniProtKB/TrEMBL
-
A2NX49
-
XM_054315910.1 → XP_054171885.1  acetyl-CoA carboxylase 1 isoform X7
- UniProtKB/TrEMBL
-
A2NX49
-
XM_054315908.1 → XP_054171883.1  acetyl-CoA carboxylase 1 isoform X7
- UniProtKB/TrEMBL
-
A2NX49
-
XM_054315904.1 → XP_054171879.1  acetyl-CoA carboxylase 1 isoform X6
- UniProtKB/TrEMBL
-
A2NX49
-
XM_054315909.1 → XP_054171884.1  acetyl-CoA carboxylase 1 isoform X7
- UniProtKB/TrEMBL
-
A2NX49
-
XM_054315905.1 → XP_054171880.1  acetyl-CoA carboxylase 1 isoform X6
- UniProtKB/TrEMBL
-
A2NX49
-
XM_054315900.1 → XP_054171875.1  acetyl-CoA carboxylase 1 isoform X4
- UniProtKB/TrEMBL
-
A2NX49
-
XM_054315906.1 → XP_054171881.1  acetyl-CoA carboxylase 1 isoform X6
- UniProtKB/TrEMBL
-
A2NX49
-
XM_054315903.1 → XP_054171878.1  acetyl-CoA carboxylase 1 isoform X5
- UniProtKB/TrEMBL
-
A2NX49
-
XM_054315902.1 → XP_054171877.1  acetyl-CoA carboxylase 1 isoform X5
- UniProtKB/TrEMBL
-
A2NX49
-
XM_054315912.1 → XP_054171887.1  acetyl-CoA carboxylase 1 isoform X13
The following Reference Sequences have been suppressed. Explain
These RefSeqs were suppressed for the
cited reason(s). Suppressed RefSeqs do not appear in BLAST databases, related
sequence links, or BLAST links (BLink), but may still be retrieved by clicking on
their accession.version below.
-
NM_000664.3: Suppressed sequence
- Description
- NM_000664.3: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
-
NM_198835.1: Suppressed sequence
- Description
- NM_198835.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.