Protein kinase superfamily protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Full Name: Protein kinase superfamily protein
Primary source: TAIR:AT3G57750
Locus tag: AT3G57750
See related: Araport:AT3G57750
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: hopZ-ETI-deficient 1; ZED1
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Genomic context

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See in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 1

Sequence:: Chromosome: 3; NC_003074.8 (21393963..21395288)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A natural diversity screen in Arabidopsis thaliana reveals determinants for HopZ1a recognition in the ZAR1-ZED1 immune complex.
Title: A natural diversity screen in Arabidopsis thaliana reveals determinants for HopZ1a recognition in the ZAR1-ZED1 immune complex.
intracellular nucleotide-binding leucine-rich repeat domain-containing receptors (NLRs), SZE1 and SZE2, interact with HopZ1a and function together with ZED1 to change the intramolecular interactions of ZAR1, leading to its activation, critical for HopZ1a-triggered immunity
Title: Two Arabidopsis Receptor-like Cytoplasmic Kinases SZE1 and SZE2 Associate with the ZAR1-ZED1 Complex and Are Required for Effector-Triggered Immunity.
Pseudomonas syringae acetyltransferase HopZ1a can acetylate members of a family of 'receptor-like cytoplasmic kinases' (RLCK family VII; also known as PBS1-like kinases, or PBLs) and promote their interaction with ZED1 and ZAR1 to form a ZAR1-ZED1-PBL ternary complex.
Title: Perturbations of the ZED1 pseudokinase activate plant immunity.
ZED1 is involved in regulation of the ambient temperature-sensitive intersection of immune response and growth in the absence of pathogens.ZED1 meditates the immune response by modulating SNC1 transcription.
Title: Arabidopsis ZED1-related kinases mediate the temperature-sensitive intersection of immune response and growth homeostasis.
role in Pseudomonas syringae HopZ1a recognition
Title: The rise of the undead: pseudokinases as mediators of effector-triggered immunity.
ZED1 acts as a decoy to lure HopZ1a to the ZAR1-resistance complex, resulting in ETI activation. [ZED1] [hopZ-ETI-deficient1]
Title: The Arabidopsis ZED1 pseudokinase is required for ZAR1-mediated immunity induced by the Pseudomonas syringae type III effector HopZ1a.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_001035801.1

Supported by ESTs:

NM_115635.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
NOT enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within defense response to Gram-negative bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to temperature stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to temperature stimulus	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Protein kinase superfamily protein

NP_001030878.1

Protein kinase superfamily protein; FUNCTIONS IN: protein kinase activity, kinase activity, ATP binding; INVOLVED IN: protein amino acid phosphorylation; LOCATED IN: cellular_component unknown; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009); BEST Arabidopsis thaliana protein match is: Protein kinase superfamily protein (TAIR:AT3G57710.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NP_567053.1

Protein kinase superfamily protein; FUNCTIONS IN: protein kinase activity, kinase activity, ATP binding; INVOLVED IN: protein amino acid phosphorylation; LOCATED IN: cellular_component unknown; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009); BEST Arabidopsis thaliana protein match is: Protein kinase superfamily protein (TAIR:AT3G57710.1); Has 51261 Blast hits to 50836 proteins in 2124 species: Archae - 20; Bacteria - 5135; Metazoa - 13711; Fungi - 2551; Plants - 24631; Viruses - 129; Other Eukaryotes - 5084 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

21393963..21395288

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_115635.4 → NP_567053.1 Protein kinase superfamily protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_567053.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8LGB6, Q9SVY9

UniProtKB/TrEMBL

A0A654FIQ7

Conserved Domains (1) summary

cd14066
Location:55 → 330

STKc_IRAK; Catalytic domain of the Serine/Threonine kinases, Interleukin-1 Receptor Associated Kinases and related STKs
NM_001035801.1 → NP_001030878.1 Protein kinase superfamily protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001030878.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8LGB6, Q9SVY9

UniProtKB/TrEMBL

A0A654FIQ7

Conserved Domains (1) summary

cd14066
Location:55 → 330

STKc_IRAK; Catalytic domain of the Serine/Threonine kinases, Interleukin-1 Receptor Associated Kinases and related STKs