UBC22 ubiquitin-conjugating enzyme 22 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: UBC22
Official Full Name: ubiquitin-conjugating enzyme 22
Primary source: TAIR:AT5G05080
Locus tag: AT5G05080
See related: Araport:AT5G05080
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATUBC22; MUG13.6; MUG13_6; ubiquitin-conjugating enzyme 22
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Genomic context

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See UBC22 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 7

Sequence:: Chromosome: 5; NC_003076.8 (1498438..1500784, complement)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Arabidopsis UBC22, an E2 able to catalyze lysine-11 specific ubiquitin linkage formation, has multiple functions in plant growth and immunity.
Title: Arabidopsis UBC22, an E2 able to catalyze lysine-11 specific ubiquitin linkage formation, has multiple functions in plant growth and immunity.
Arabidopsis UBC22 could catalyze ubiquitin dimer formation in vitro in a Lys11-dependent manner, suggesting that it likely catalyzes Lys11-linked ubiquitination in plants. This study has identified one biochemical property of UBC22 and revealed a novel function in female gametophyte development.
Title: Arabidopsis ubiquitin-conjugating enzyme UBC22 is required for female gametophyte development and likely involved in Lys11-linked ubiquitination.

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General gene information

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Homology

Orthologs from OrthoDB

NM_001085061.1

Supported by ESTs:

NM_001342801.1

Supported by ESTs:

NM_001342802.1

Supported by ESTs:

NM_120590.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables ubiquitin conjugating enzyme activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-protein transferase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ubiquitin-conjugating enzyme 22

NP_001078530.1

ubiquitin-conjugating enzyme 22 (UBC22); CONTAINS InterPro DOMAIN/s: Ubiquitin-conjugating enzyme/RWD-like (InterPro:IPR016135), Ubiquitin-conjugating enzyme, E2 (InterPro:IPR000608); BEST Arabidopsis thaliana protein match is: ubiquiting-conjugating enzyme 2 (TAIR:AT2G02760.1); Has 9428 Blast hits to 9407 proteins in 388 species: Archae - 0; Bacteria - 0; Metazoa - 4145; Fungi - 1971; Plants - 1789; Viruses - 23; Other Eukaryotes - 1500 (source: NCBI BLink).

NP_568148.1

ubiquitin-conjugating enzyme 22 (UBC22); CONTAINS InterPro DOMAIN/s: Ubiquitin-conjugating enzyme/RWD-like (InterPro:IPR016135), Ubiquitin-conjugating enzyme, E2 (InterPro:IPR000608); BEST Arabidopsis thaliana protein match is: ubiquiting-conjugating enzyme 2 (TAIR:AT2G02760.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

1498438..1500784 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_120590.3 → NP_568148.1 ubiquitin-conjugating enzyme 22 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_568148.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9FF66

UniProtKB/TrEMBL

A0A178UL56, A0A5S9Y1H7

Conserved Domains (1) summary

cd00195
Location:12 → 151

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
NM_001342801.1 → NP_001332674.1 ubiquitin-conjugating enzyme 22 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9FF66

UniProtKB/TrEMBL

A0A178UL56, A0A5S9Y1H7

Conserved Domains (1) summary

cd00195
Location:12 → 151

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
NM_001342802.1 → NP_001332673.1 ubiquitin-conjugating enzyme 22 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9FF66

UniProtKB/TrEMBL

A0A178UL56, A0A5S9Y1H7

Conserved Domains (1) summary

cd00195
Location:12 → 151

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
NM_001085061.1 → NP_001078530.1 ubiquitin-conjugating enzyme 22 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001078530.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9FF66

UniProtKB/TrEMBL

A0A178UL56, A0A5S9Y1H7

Conserved Domains (1) summary

cd00195
Location:12 → 151

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...