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    EIF2 ALPHA eukaryotic translation initiation factor 2 alpha subunit [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 830430, updated on 18-Sep-2024

    Summary

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    Official Symbol
    EIF2 ALPHA
    Official Full Name
    eukaryotic translation initiation factor 2 alpha subunit
    Primary source
    TAIR:AT5G05470
    Locus tag
    AT5G05470
    See related
    Araport:AT5G05470
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATEIF2-A2; EIF2-A2; eukaryotic translation initiation factor 2 alpha subunit
    Summary
    Encodes an eIF2alpha homolog that can be phosphorylated by GCN2 in vitro.
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    Genomic context

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    See EIF2 ALPHA in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    7
    Sequence:
    Chromosome: 5; NC_003076.8 (1620458..1622340)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Glycosyl hydrolase family 85 Neighboring gene ncRNA Neighboring gene Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase A protein Neighboring gene Rad21/Rec8-like family protein Neighboring gene Pollen Ole e 1 allergen and extensin family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phosphorylation of the alpha-subunit of plant eukaryotic initiation factor 2 prevents its association with polysomes but does not considerably suppress protein synthesis. Zhigailov AV, et al. Plant Sci, 2022 Apr. PMID 35193739
    2. GCN2-dependent phosphorylation of eukaryotic translation initiation factor-2alpha in Arabidopsis. Zhang Y, et al. J Exp Bot, 2008. PMID 18603615, Free PMC Article
    3. The GCN2 homologue in Arabidopsis thaliana interacts with uncharged tRNA and uses Arabidopsis eIF2α molecules as direct substrates. Li MW, et al. Plant Biol (Stuttg), 2013 Jan. PMID 22672016
    4. Capturing the phosphorylation and protein interaction landscape of the plant TOR kinase. Van Leene J, et al. Nat Plants, 2019 Mar. PMID 30833711
    5. A Pan-plant Protein Complex Map Reveals Deep Conservation and Novel Assemblies. McWhite CD, et al. Cell, 2020 Apr 16. PMID 32191846, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Phosphorylation of the alpha-subunit of plant eukaryotic initiation factor 2 prevents its association with polysomes but does not considerably suppress protein synthesis.
      Title: Phosphorylation of the alpha-subunit of plant eukaryotic initiation factor 2 prevents its association with polysomes but does not considerably suppress protein synthesis.
    2. The in vitro assays demonstrate the binding of the C-terminus of AtGCN2 to uncharged tRNA molecules and the enzymatic activities of AtGCN2 on both eIF2alpha homologues in A. thaliana.
      Title: The GCN2 homologue in Arabidopsis thaliana interacts with uncharged tRNA and uses Arabidopsis eIF2α molecules as direct substrates.
    3. Analysis of wild-type and GT8359 (null mutant for AtGCN2) plants infected with Turnip yellow mosaic virus or Turnip crinkle virus showed that AteIF2alpha was not phosphorylated.
      Title: GCN2-dependent phosphorylation of eukaryotic translation initiation factor-2alpha in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_120629.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation initiation factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    part_of eukaryotic translation initiation factor 2 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 2 alpha subunit
    NP_196166.1
    • eukaryotic translation initiation factor 2 alpha subunit (EIF2 ALPHA); FUNCTIONS IN: RNA binding, translation initiation factor activity; INVOLVED IN: translation; LOCATED IN: eukaryotic translation initiation factor 2 complex; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Nucleic acid-binding, OB-fold-like (InterPro:IPR016027), Nucleic acid-binding, OB-fold (InterPro:IPR012340), Ribosomal protein S1, RNA-binding domain (InterPro:IPR003029), Eukaryotic translation initiation factor 2, alpha subunit (InterPro:IPR011488); BEST Arabidopsis thaliana protein match is: Eukaryotic translation initiation factor 2 subunit 1 (TAIR:AT2G40290.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      1620458..1622340
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_120629.3 → NP_196166.1  eukaryotic translation initiation factor 2 alpha subunit [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_196166.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9C5N6, Q9FE78
      UniProtKB/TrEMBL
      A0A178UAX7, A0A5S9Y2G1, A0A654FYH9
      Conserved Domains (1) summary
      PTZ00248
      Location:5 → 315
      PTZ00248; eukaryotic translation initiation factor 2 subunit 1; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FE78.1

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