PYL5 Polyketide cyclase/dehydrase and lipid transport superfamily protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: PYL5
Official Full Name: Polyketide cyclase/dehydrase and lipid transport superfamily protein
Primary source: TAIR:AT5G05440
Locus tag: AT5G05440
See related: Araport:AT5G05440
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: AtPYL5; K18I23.25; K18I23_25; PYRABACTIN RESISTANCE 1-LIKE 5; RCAR8; regulatory component of ABA receptor 8
Summary: Encodes a member of the PYR (pyrabactin resistance)/PYL(PYR1-like)/RCAR (regulatory components of ABA receptor) family proteins with 14 members. PYR/PYL/RCAR family proteins function as abscisic acid sensors. Mediate ABA-dependent regulation of protein phosphatase 2Cs ABI1 and ABI2.
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Genomic context

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See PYL5 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 1

Sequence:: Chromosome: 5; NC_003076.8 (1608988..1610527)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Of the six members of the PYR/PYL/RCAR family expressed in guard cells, PYL2 is sufficient for guard cell abscisc acid-induced responses, whereas in the responses to CO2, PYL4 and PYL5 are essential.
Title: The role of Arabidopsis ABA receptors from the PYR/PYL/RCAR family in stomatal acclimation and closure signal integration.
Using molecular dynamics simulations, the complete abscisic acid recognition pathways by two subtype receptors, PYL5 and PYL10, and a modified PYL5 receptor through tyrosine nitration, have been established.
Title: Dewetting Controls Plant Hormone Perception and Initiation of Drought Resistance Signaling.
role in drought stress tolerance
Title: Overexpression of AtPYL5 under the control of guard cell specific promoter improves drought stress tolerance in Arabidopsis.
Data reveal that this CPL is an important site necessary for both the phosphatase activity of ABI2 and the functional interaction between ABI2 and PYL5/9 ABA receptors.
Title: Identification of an important site for function of the type 2C protein phosphatase ABI2 in abscisic acid signalling in Arabidopsis.
PYL5 activates abscisic acid signaling through direct inhibition of clade A PP2Cs. Over-expression leads to a globally enhanced response to abscisic acid and enhanced drought resistance. [PYL5]
Title: Modulation of drought resistance by the abscisic acid receptor PYL5 through inhibition of clade A PP2Cs.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_120626.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables abscisic acid binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables signaling receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in abscisic acid-activated signaling pathway	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: Polyketide cyclase/dehydrase and lipid transport superfamily protein

NP_196163.1

PYRABACTIN RESISTANCE 1-LIKE 5 (PYL5); CONTAINS InterPro DOMAIN/s: Polyketide cyclase/dehydrase (InterPro:IPR019587); BEST Arabidopsis thaliana protein match is: PYR1-like 6 (TAIR:AT2G40330.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

1608988..1610527

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_120626.3 → NP_196163.1 Polyketide cyclase/dehydrase and lipid transport superfamily protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_196163.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9FLB1

UniProtKB/TrEMBL

A0A178ULK5, A0A5S9Y1M7, A0A654FYQ3

Conserved Domains (1) summary

cd07821
Location:58 → 198

PYR_PYL_RCAR_like; Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins