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    HAM2 histone acetyltransferase of the MYST family 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 830834, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HAM2
    Official Full Name
    histone acetyltransferase of the MYST family 2
    Primary source
    TAIR:AT5G09740
    Locus tag
    AT5G09740
    See related
    Araport:AT5G09740
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F17I14.70; F17I14_70; HAC11; HAG05; HAG5; HISTONE ACETYLTRANSFERASE OF THE CBP FAMILY 11; HISTONE ACETYLTRANSFERASE OF THE GNAT/MYST SUPERFAMILY 5; histone acetyltransferase of the MYST family 2
    Summary
    Encodes an enzyme with histone acetyltransferase activity. HAM2 primarily acetylate histone H4, but also display some ability to acetylate H3. Prior acetylation of lysine 5 on histone H4 reduces radioactive acetylation by either HAM2.
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    Genomic context

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    See HAM2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    9
    Sequence:
    Chromosome: 5; NC_003076.8 (3021932..3024763, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Magnesium transporter CorA-like family protein Neighboring gene beta-xylosidase 3 Neighboring gene basic helix-loop-helix (bHLH) DNA-binding superfamily protein Neighboring gene tRNA-Glu

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Requirement of histone acetyltransferases HAM1 and HAM2 for epigenetic modification of FLC in regulating flowering in Arabidopsis. Xiao J, et al. J Plant Physiol, 2013 Mar 1. PMID 23273925
    2. Arabidopsis MRG domain proteins bridge two histone modifications to elevate expression of flowering genes. Xu Y, et al. Nucleic Acids Res, 2014. PMID 25183522, Free PMC Article
    3. Participation of chromatin-remodeling proteins in the repair of ultraviolet-B-damaged DNA. Campi M, et al. Plant Physiol, 2012 Feb. PMID 22170978, Free PMC Article
    4. In vitro specificities of Arabidopsis co-activator histone acetyltransferases: implications for histone hyperacetylation in gene activation. Earley KW, et al. Plant J, 2007 Nov. PMID 17877703
    5. Erasure of histone acetylation by Arabidopsis HDA6 mediates large-scale gene silencing in nucleolar dominance. Earley K, et al. Genes Dev, 2006 May 15. PMID 16648464, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HAM2 may affect flowering time in Arabidopsis by epigenetic modification of FLOWERING LOCUS C and MADS-box Affecting Flowering genes 3/4 chromatins at H4K5 acetylation.
      Title: Requirement of histone acetyltransferases HAM1 and HAM2 for epigenetic modification of FLC in regulating flowering in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001085089.1
    NM_121011.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables histone acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to UV-B IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of NuA4 histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    histone acetyltransferase of the MYST family 2
    NP_001078558.1
    • histone acetyltransferase of the MYST family 2 (HAM2); FUNCTIONS IN: histone acetyltransferase activity, zinc ion binding, nucleic acid binding; INVOLVED IN: chromatin assembly or disassembly, regulation of transcription; LOCATED IN: nucleus; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Winged helix-turn-helix transcription repressor DNA-binding (InterPro:IPR011991), Chromo domain (InterPro:IPR000953), Acyl-CoA N-acyltransferase (InterPro:IPR016181), MOZ/SAS-like protein (InterPro:IPR002717); BEST Arabidopsis thaliana protein match is: histone acetyltransferase of the MYST family 1 (TAIR:AT5G64610.1); Has 1870 Blast hits to 1533 proteins in 232 species: Archae - 0; Bacteria - 4; Metazoa - 1014; Fungi - 461; Plants - 151; Viruses - 0; Other Eukaryotes - 240 (source: NCBI BLink).
    NP_196536.1
    • histone acetyltransferase of the MYST family 2 (HAM2); FUNCTIONS IN: histone acetyltransferase activity, zinc ion binding, nucleic acid binding; INVOLVED IN: chromatin assembly or disassembly, regulation of transcription; LOCATED IN: nucleus; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Winged helix-turn-helix transcription repressor DNA-binding (InterPro:IPR011991), Acyl-CoA N-acyltransferase (InterPro:IPR016181), MOZ/SAS-like protein (InterPro:IPR002717), Chromo domain (InterPro:IPR000953); BEST Arabidopsis thaliana protein match is: histone acetyltransferase of the MYST family 1 (TAIR:AT5G64610.1); Has 1635 Blast hits to 1565 proteins in 235 species: Archae - 0; Bacteria - 4; Metazoa - 872; Fungi - 459; Plants - 89; Viruses - 0; Other Eukaryotes - 211 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      3021932..3024763 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_121011.4 → NP_196536.1  histone acetyltransferase of the MYST family 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_196536.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C0SVP1, F4KE11, Q8GZ97, Q8LCD4, Q9LXD7
      UniProtKB/TrEMBL
      A0A178U8L6, A0A5S9Y3C3, A0A7G2F698
      Conserved Domains (1) summary
      PLN00104
      Location:1 → 445
      PLN00104; MYST -like histone acetyltransferase; Provisional

    2. NM_001085089.1 → NP_001078558.1  histone acetyltransferase of the MYST family 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001078558.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2F698
      Conserved Domains (3) summary
      PLN00104
      Location:1 → 367
      PLN00104; MYST -like histone acetyltransferase; Provisional
      pfam11717
      Location:60 → 118
      Tudor-knot; RNA binding activity-knot of a chromodomain
      cl17182
      Location:172 → 344
      NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LXD7.1

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