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    APY2 apyrase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831946, updated on 18-Sep-2024

    Summary

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    Official Symbol
    APY2
    Official Full Name
    apyrase 2
    Primary source
    TAIR:AT5G18280
    Locus tag
    AT5G18280
    See related
    Araport:AT5G18280
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    APYRASE; apyrase 2; ATAPY2; MRG7.24; MRG7_24
    Summary
    Encodes an enzyme with ATPase and ADPase activity (an apyrase) that when mutated in combination with ATAPY1 causes a complete inhibition of pollen germination.
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    Genomic context

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    See APY2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    9
    Sequence:
    Chromosome: 5; NC_003076.8 (6050514..6054386, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene RING/U-box superfamily protein Neighboring gene NAC domain containing protein 87 Neighboring gene Aquaporin-like superfamily protein Neighboring gene ncRNA Neighboring gene NAC domain containing protein 88

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. APYRASE1/2 mediate red light-induced de-etiolation growth in Arabidopsis seedlings. Weeraratne G, et al. Plant Physiol, 2022 Jun 27. PMID 35357495, Free PMC Article
    2. Modulation of Root Skewing in Arabidopsis by Apyrases and Extracellular ATP. Yang X, et al. Plant Cell Physiol, 2015 Nov. PMID 26412783
    3. Apyrase suppression raises extracellular ATP levels and induces gene expression and cell wall changes characteristic of stress responses. Lim MH, et al. Plant Physiol, 2014 Apr. PMID 24550243, Free PMC Article
    4. Effects of chemical inhibitors and apyrase enzyme further document a role for apyrases and extracellular ATP in the opening and closing of stomates in Arabidopsis. Clark G, et al. Plant Signal Behav, 2013 Nov. PMID 23989340, Free PMC Article
    5. Role for apyrases in polar auxin transport in Arabidopsis. Liu X, et al. Plant Physiol, 2012 Dec. PMID 23071251, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. APYRASE1/2 mediate red light-induced de-etiolation growth in Arabidopsis seedlings.
      Title: APYRASE1/2 mediate red light-induced de-etiolation growth in Arabidopsis seedlings.
    2. Study reports that APY1 and, to a lesser extent, APY2 help control root skewing, the right-slanted growth of roots, in Arabidopsis.
      Title: Modulation of Root Skewing in Arabidopsis by Apyrases and Extracellular ATP.
    3. low levels of apyrase chemical inhibitors can induce stomatal opening in the dark, while apyrase enzyme blocks abscissic acid-induced stomatal closure.
      Title: Effects of chemical inhibitors and apyrase enzyme further document a role for apyrases and extracellular ATP in the opening and closing of stomates in Arabidopsis.
    4. APY1, APY2, and extracellular ATP play important roles in the signaling steps that link biotic stresses to plant defense responses and growth changes.
      Title: Apyrase suppression raises extracellular ATP levels and induces gene expression and cell wall changes characteristic of stress responses.
    5. Suppression of APY1/APY2 expression results in a significant inhibition of polar auxin transport in Arabidopsis hypocotyls and roots.
      Title: Role for apyrases in polar auxin transport in Arabidopsis.
    6. AtAPY1 and AtAPY2 are Golgi-localized nucleotide diphosphatases and are likely to have roles in regulating UDP/GDP concentrations in the Golgi lumen.
      Title: AtAPY1 and AtAPY2 function as Golgi-localized nucleoside diphosphatases in Arabidopsis thaliana.
    7. Both short-term inhibition of ectoapyrase activity by polyclonal antibodies and long-term suppression of APY1 and APY2 transcript levels significantly disrupt normal stomatal behavior in light.
      Title: Extracellular nucleotides and apyrases regulate stomatal aperture in Arabidopsis.
    8. acts to reduce the concentration of extracellular nucleotides, highest expression in rapidly growing tissues and/or tissues that accumulate high auxin levels
      Title: Apyrases (nucleoside triphosphate-diphosphohydrolases) play a key role in growth control in Arabidopsis.
    Submit: New GeneRIF Correction

    General gene information

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    NM_121833.7

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    		  
    enables nucleoside diphosphate phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within pollen germination IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus HDA PubMed 
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi medial cisterna HDA PubMed 
    located_in Golgi medial cisterna IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in endosome HDA PubMed 
    located_in trans-Golgi network HDA PubMed 

    General protein information

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    Preferred Names
    apyrase 2
    NP_197329.5
    • apyrase 2 (APY2); CONTAINS InterPro DOMAIN/s: Nucleoside phosphatase GDA1/CD39 (InterPro:IPR000407); BEST Arabidopsis thaliana protein match is: apyrase 1 (TAIR:AT3G04080.1); Has 1437 Blast hits to 1429 proteins in 222 species: Archae - 0; Bacteria - 35; Metazoa - 609; Fungi - 299; Plants - 361; Viruses - 0; Other Eukaryotes - 133 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      6050514..6054386 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_121833.7 → NP_197329.5  apyrase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4JWK7, I1VCB1, Q8L704, Q9M7B3, Q9SPM5
      UniProtKB/TrEMBL
      A0A178U9X1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SPM5.1

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