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    CESA4 cellulose synthase A4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834426, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CESA4
    Official Full Name
    cellulose synthase A4
    Primary source
    TAIR:AT5G44030
    Locus tag
    AT5G44030
    See related
    Araport:AT5G44030
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    cellulose synthase A4; IRREGULAR XYLEM 5; IRX5; MRH10.14; MRH10_14; NWS2
    Summary
    Encodes a cellulose synthase involved in secondary cell wall biosynthesis. Confers resistance towards bacterial and fungal pathogens, independent of salicylic acid, ethylene and jasmonate signaling.
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    Genomic context

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    See CESA4 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    12
    Sequence:
    Chromosome: 5; NC_003076.8 (17714390..17719723)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene fanconi anemia group F protein (FANCF) Neighboring gene HAD superfamily, subfamily IIIB acid phosphatase Neighboring gene eisosome SEG2-like protein Neighboring gene MATE efflux family protein Neighboring gene embryo sac development arrest protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Impairment of cellulose synthases required for Arabidopsis secondary cell wall formation enhances disease resistance. Hernández-Blanco C, et al. Plant Cell, 2007 Mar. PMID 17351116, Free PMC Article
    2. Exploiting CELLULOSE SYNTHASE (CESA) Class Specificity to Probe Cellulose Microfibril Biosynthesis. Kumar M, et al. Plant Physiol, 2018 May. PMID 29523715, Free PMC Article
    3. Phylogenetically distinct cellulose synthase genes support secondary wall thickening in arabidopsis shoot trichomes and cotton fiber. Betancur L, et al. J Integr Plant Biol, 2010 Feb. PMID 20377682
    4. Interactions between membrane-bound cellulose synthases involved in the synthesis of the secondary cell wall. Timmers J, et al. FEBS Lett, 2009 Mar 18. PMID 19258017
    5. Elucidating the mechanisms of assembly and subunit interaction of the cellulose synthase complex of Arabidopsis secondary cell walls. Atanassov II, et al. J Biol Chem, 2009 Feb 6. PMID 19056734

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CESA4 role in the cellulose microfibril biosynthesis in the secondary cell wall.
      Title: Exploiting CELLULOSE SYNTHASE (CESA) Class Specificity to Probe Cellulose Microfibril Biosynthesis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001344528.1
    NM_001344529.1
    NM_123770.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables cellulose synthase (UDP-forming) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cellulose synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables glycosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    NOT involved_in cell wall thickening IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellulose biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cellulose biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cellulose biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    NOT involved_in ethylene-activated signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    NOT involved_in jasmonic acid mediated signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within plant-type cell wall biogenesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within plant-type secondary cell wall biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    NOT involved_in salicylic acid mediated signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    cellulose synthase A4
    NP_199216.2
    • cellulose synthase A4 (CESA4); FUNCTIONS IN: cellulose synthase activity, transferase activity, transferring glycosyl groups; INVOLVED IN: cellulose biosynthetic process, plant-type cell wall biogenesis, defense response to bacterium, defense response to fungus, secondary cell wall biogenesis; LOCATED IN: membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 11 growth stages; CONTAINS InterPro DOMAIN/s: Cellulose synthase (InterPro:IPR005150); BEST Arabidopsis thaliana protein match is: Cellulose synthase family protein (TAIR:AT5G05170.1); Has 3263 Blast hits to 2832 proteins in 640 species: Archae - 9; Bacteria - 1071; Metazoa - 1; Fungi - 31; Plants - 2051; Viruses - 7; Other Eukaryotes - 93 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      17714390..17719723
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_123770.4 → NP_199216.2  cellulose synthase A4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_199216.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WQW9, Q84JA6, Q8GZN8, Q9FNC3
      UniProtKB/TrEMBL
      A0A068FIL6, A0A178ULT0, A0A5S9YD41
      Conserved Domains (3) summary
      PLN02915
      Location:6 → 1049
      PLN02915; cellulose synthase A [UDP-forming], catalytic subunit
      pfam14569
      Location:16 → 81
      zf-UDP; Zinc-binding RING-finger
      cl11394
      Location:463 → 798
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

    2. NM_001344528.1 → NP_001332727.1  cellulose synthase A4 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178ULT0, A0A1R7T3H6, A0A5S9YD41

    3. NM_001344529.1 → NP_001332726.1  cellulose synthase A4 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1R7T3H5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q84JA6.1

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