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    CNGC5 cyclic nucleotide gated channel 5 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 835905, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CNGC5
    Official Full Name
    cyclic nucleotide gated channel 5
    Primary source
    TAIR:AT5G57940
    Locus tag
    AT5G57940
    See related
    Araport:AT5G57940
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATCNGC5; cyclic nucleotide gated channel 5; MTI20.20; MTI20_20
    Summary
    Encodes a cyclic GMP activated Ca2+-permeable cation channel in the plasma membrane of guard cells.
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    Genomic context

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    See CNGC5 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    9
    Sequence:
    Chromosome: 5; NC_003076.8 (23456565..23460621)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene early nodulin-like protein 10 Neighboring gene APO RNA-binding protein (DUF794) Neighboring gene 26S proteasome regulatory subunit Neighboring gene GTP-binding protein, HflX

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of cyclic GMP-activated nonselective Ca2+-permeable cation channels and associated CNGC5 and CNGC6 genes in Arabidopsis guard cells. Wang YF, et al. Plant Physiol, 2013 Oct. PMID 24019428, Free PMC Article
    2. Three CNGC Family Members, CNGC5, CNGC6, and CNGC9, Are Required for Constitutive Growth of Arabidopsis Root Hairs as Ca(2+)-Permeable Channels. Tan YQ, et al. Plant Commun, 2020 Jan 13. PMID 33404548, Free PMC Article
    3. Genes encoding calmodulin-binding proteins in the Arabidopsis genome. Reddy VS, et al. J Biol Chem, 2002 Mar 22. PMID 11782485
    4. Uncovering Arabidopsis membrane protein interactome enriched in transporters using mating-based split ubiquitin assays and classification models. Chen J, et al. Front Plant Sci, 2012. PMID 22737156, Free PMC Article
    5. 14-3-3 proteins fine-tune plant nutrient metabolism. Shin R, et al. FEBS Lett, 2011 Jan 3. PMID 21094157

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Three CNGC Family Members, CNGC5, CNGC6, and CNGC9, Are Required for Constitutive Growth of Arabidopsis Root Hairs as Ca(2+)-Permeable Channels.
      Title: Three CNGC Family Members, CNGC5, CNGC6, and CNGC9, Are Required for Constitutive Growth of Arabidopsis Root Hairs as Ca(2+)-Permeable Channels.
    2. The CNGC5 and CNGC6 genes encode unique cyclic GMP-activated nonselective Ca(2+)-permeable cation channels in the plasma membrane of Arabidopsis guard cells.
      Title: Identification of cyclic GMP-activated nonselective Ca2+-permeable cation channels and associated CNGC5 and CNGC6 genes in Arabidopsis guard cells.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_125179.5
    NM_180878.2
    NM_203224.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables calcium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calmodulin binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables intracellularly cGMP-activated cation channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in root hair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cyclic nucleotide gated channel 5
    NP_200602.2
    • cyclic nucleotide gated channel 5 (CNGC5); FUNCTIONS IN: cyclic nucleotide binding, calmodulin binding, potassium channel activity; INVOLVED IN: ion transport, transmembrane transport; LOCATED IN: membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Cyclic nucleotide-binding (InterPro:IPR000595), Ion transport (InterPro:IPR005821), Cyclic nucleotide-binding-like (InterPro:IPR018490), RmlC-like jelly roll fold (InterPro:IPR014710), IQ calmodulin-binding region (InterPro:IPR000048); BEST Arabidopsis thaliana protein match is: cyclic nucleotide-gated channel 6 (TAIR:AT2G23980.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_851209.1
    • cyclic nucleotide gated channel 5 (CNGC5); FUNCTIONS IN: cyclic nucleotide binding, calmodulin binding, potassium channel activity; INVOLVED IN: ion transport, transmembrane transport; LOCATED IN: membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Cyclic nucleotide-binding (InterPro:IPR000595), Ion transport (InterPro:IPR005821), Cyclic nucleotide-binding-like (InterPro:IPR018490), RmlC-like jelly roll fold (InterPro:IPR014710), IQ calmodulin-binding region (InterPro:IPR000048); BEST Arabidopsis thaliana protein match is: cyclic nucleotide-gated channel 6 (TAIR:AT2G23980.1); Has 3705 Blast hits to 3494 proteins in 271 species: Archae - 0; Bacteria - 60; Metazoa - 1584; Fungi - 66; Plants - 1032; Viruses - 0; Other Eukaryotes - 963 (source: NCBI BLink).
    NP_974953.1
    • cyclic nucleotide gated channel 5 (CNGC5); FUNCTIONS IN: cyclic nucleotide binding, calmodulin binding, potassium channel activity; INVOLVED IN: ion transport, transmembrane transport; LOCATED IN: membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Cyclic nucleotide-binding (InterPro:IPR000595), Ion transport (InterPro:IPR005821), Cyclic nucleotide-binding-like (InterPro:IPR018490), RmlC-like jelly roll fold (InterPro:IPR014710), IQ calmodulin-binding region (InterPro:IPR000048); BEST Arabidopsis thaliana protein match is: cyclic nucleotide-gated channel 6 (TAIR:AT2G23980.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      23456565..23460621
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_125179.5 → NP_200602.2  cyclic nucleotide gated channel 5 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_200602.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8RWS9, Q9XFS3
      UniProtKB/TrEMBL
      A0A5S9YF62, A0A7G2FK21, B9DGT1
      Conserved Domains (2) summary
      PLN03192
      Location:84 → 550
      PLN03192; Voltage-dependent potassium channel; Provisional
      cd00038
      Location:498 → 629
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

    2. NM_180878.2 → NP_851209.1  cyclic nucleotide gated channel 5 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_851209.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8RWS9, Q9XFS3
      UniProtKB/TrEMBL
      A0A5S9YF62, A0A7G2FK21, B9DGT1
      Conserved Domains (2) summary
      PLN03192
      Location:84 → 550
      PLN03192; Voltage-dependent potassium channel; Provisional
      cd00038
      Location:498 → 629
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

    3. NM_203224.1 → NP_974953.1  cyclic nucleotide gated channel 5 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974953.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2FK21
      Conserved Domains (3) summary
      COG0664
      Location:485 → 610
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:491 → 622
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      pfam00520
      Location:135 → 420
      Ion_trans; Ion transport protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8RWS9.1

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