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    TRIM25 tripartite motif containing 25 [ Homo sapiens (human) ]

    Gene ID: 7706, updated on 4-Jan-2025

    Summary

    Official Symbol
    TRIM25provided by HGNC
    Official Full Name
    tripartite motif containing 25provided by HGNC
    Primary source
    HGNC:HGNC:12932
    See related
    Ensembl:ENSG00000121060 MIM:600453; AllianceGenome:HGNC:12932
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EFP; Z147; RNF147; ZNF147
    Summary
    The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein is an RNA binding protein, functions as a ubiquitin E3 ligase and is involved in multiple cellular processes, including regulation of antiviral innate immunity. [provided by RefSeq, Sep 2021]
    Annotation information
    Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
    Expression
    Ubiquitous expression in bone marrow (RPKM 21.8), skin (RPKM 15.8) and 25 other tissues See more
    Orthologs
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    Genomic context

    See TRIM25 in Genome Data Viewer
    Location:
    17q22
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (56887909..56914049, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (57765556..57791697, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (54965270..54991410, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904037 Neighboring gene RNA, U6 small nuclear 1158, pseudogene Neighboring gene mouse mammary tumor virus receptor homolog 2 Neighboring gene microRNA 3614 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12419 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:54990878-54991548 Neighboring gene MPRA-validated peak2907 silencer Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr17:55002389-55002923 Neighboring gene ribosomal protein S15a pseudogene Neighboring gene coilin Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8742 Neighboring gene Sharpr-MPRA regulatory region 7909 Neighboring gene uncharacterized LOC105371836

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (20 hits/1327 screens)

    EBI GWAS Catalog

    Description
    Many sequence variants affecting diversity of adult human height.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of tripartite motif containing 25 (TRIM25) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag Gene silencing of endogenously expressed TRIM 25 inhibits viral release, suggesting the interaction between HIV-1 Gag and TRIM25 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in ERAD pathway PubMed 
    NOT involved_in RIG-I signaling pathway PubMed 
    involved_in antiviral innate immune response PubMed 
    involved_in cellular response to leukemia inhibitory factor  
    involved_in cytoplasmic pattern recognition receptor signaling pathway PubMed 
    involved_in innate immune response PubMed 
    involved_in innate immune response  
    involved_in negative regulation of viral entry into host cell  
    involved_in positive regulation of DNA-binding transcription factor activity PubMed 
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of NF-kappaB transcription factor activity PubMed 
    involved_in positive regulation of canonical NF-kappaB signal transduction PubMed 
    involved_in protein K48-linked ubiquitination PubMed 
    involved_in protein monoubiquitination PubMed 
    involved_in regulation of protein localization  
    involved_in regulation of viral entry into host cell PubMed 
    involved_in response to estrogen PubMed 
    involved_in response to oxidative stress PubMed 
    involved_in response to vitamin D  
    involved_in suppression of viral release by host  
    involved_in ubiquitin-dependent protein catabolic process PubMed 
    involved_in viral release from host cell PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm PubMed 
    located_in cytoplasmic stress granule PubMed 
    located_in cytosol  
    located_in cytosol  
    located_in nuclear body  
    located_in nucleoplasm  
    located_in nucleoplasm  

    General protein information

    Preferred Names
    E3 ubiquitin/ISG15 ligase TRIM25
    Names
    RING finger protein 147
    RING-type E3 ubiquitin transferase TRIM25
    estrogen-responsive finger protein
    tripartite motif protein TRIM25
    tripartite motif-containing protein 25
    ubiquitin/ISG15-conjugating enzyme TRIM25
    zinc finger protein 147 (estrogen-responsive finger protein)
    zinc finger protein-147
    NP_005073.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005082.5 → NP_005073.2  E3 ubiquitin/ISG15 ligase TRIM25

      See identical proteins and their annotated locations for NP_005073.2

      Status: REVIEWED

      Source sequence(s)
      AC015912, BC042541, BM146967, CF121587
      Consensus CDS
      CCDS11591.1
      UniProtKB/Swiss-Prot
      Q14258
      UniProtKB/TrEMBL
      Q59GW5
      Related
      ENSP00000323889.4, ENST00000316881.9
      Conserved Domains (3) summary
      cd13736
      Location:459 → 627
      SPRY_PRY_TRIM25; PRY/SPRY domain in tripartite motif-containing domain 25 (TRIM25)
      cl00087
      Location:180 → 252
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
      cl17238
      Location:13 → 53
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      56887909..56914049 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      57765556..57791697 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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