TIP1 Ankyrin repeat family protein with DHHC zinc finger domain-containing protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: TIP1
Official Full Name: Ankyrin repeat family protein with DHHC zinc finger domain-containing protein
Primary source: TAIR:AT5G20350
Locus tag: AT5G20350
See related: Araport:AT5G20350
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: F5O24.240; F5O24_240; TIP GROWTH DEFECTIVE 1
Summary: Encodes a protein containing ankyrin and DHHC-CRD domain. Acts to restrict the size of the swelling that forms at the beginning of root hair cell growth, possibly by a mechanism that requires RHD1. Mutant displays defects in both root hair and pollen tube growth.
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Genomic context

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See TIP1 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 13

Sequence:: Chromosome: 5; NC_003076.8 (6876441..6881506)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tip Growth Defective1 interacts with the cellulose synthase complex to regulate cellulose synthesis in Arabidopsis thaliana.
Title: Tip Growth Defective1 interacts with the cellulose synthase complex to regulate cellulose synthesis in Arabidopsis thaliana.
Results demonstrate that S-acylation is essential for normal plant cell growth and identify TIP GROWTH DEFECTIVE1 (TIP1), a plant S-acyl transferase.
Title: The TIP GROWTH DEFECTIVE1 S-acyl transferase regulates plant cell growth in Arabidopsis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_122042.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables S-acyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables S-acyltransferase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables acyl binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-cysteine S-palmitoyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell tip growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cellulose biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of secondary cell wall biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	HDA more info	PubMed
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in endosome	HDA more info	PubMed
located_in trans-Golgi network	HDA more info	PubMed

General protein information

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Preferred Names: Ankyrin repeat family protein with DHHC zinc finger domain-containing protein

NP_197535.2

TIP GROWTH DEFECTIVE 1 (TIP1); FUNCTIONS IN: acyl binding, S-acyltransferase activity; INVOLVED IN: response to salt stress, cell tip growth; EXPRESSED IN: 28 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Zinc finger, DHHC-type (InterPro:IPR001594), Ankyrin repeat-containing domain (InterPro:IPR020683), Ankyrin repeat (InterPro:IPR002110); BEST Arabidopsis thaliana protein match is: Ankyrin repeat family protein with DHHC zinc finger domain (TAIR:AT2G14255.1); Has 74376 Blast hits to 32836 proteins in 1312 species: Archae - 100; Bacteria - 6632; Metazoa - 35576; Fungi - 7192; Plants - 4422; Viruses - 788; Other Eukaryotes - 19666 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

6876441..6881506

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_122042.4 → NP_197535.2 Ankyrin repeat family protein with DHHC zinc finger domain-containing protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_197535.2

Status: REVIEWED

UniProtKB/Swiss-Prot

I1VCB2, Q0WQT8, Q52T38

UniProtKB/TrEMBL

A0A5S9Y6A0, A0A654G2X5

Conserved Domains (4) summary

PHA03095
Location:55 → 252

PHA03095; ankyrin-like protein; Provisional

sd00045
Location:64 → 95

ANK; ANK repeat [structural motif]

pfam12796
Location:38 → 128

Ank_2; Ankyrin repeats (3 copies)

cl19890
Location:256 → 506

DHHC; DHHC palmitoyltransferase