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    ATSTE14B Isoprenylcysteine carboxyl methyltransferase (ICMT) family [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 830731, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ATSTE14B
    Official Full Name
    Isoprenylcysteine carboxyl methyltransferase (ICMT) family
    Primary source
    TAIR:AT5G08335
    Locus tag
    AT5G08335
    See related
    Araport:AT5G08335
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA ISOPRENYL CYSTEINE METHYLTRANSFERASE B; ATICMTB; ICMTB; ISOPRENYL CYSTEINE METHYLTRANSFERASE B
    Summary
    Encodes an isoprenyl cysteine methylatransferase (ICMT) involved in the post-translational processing of proteins that have a C-terminal CaaX box. This protein appears to have higher catalytic activity and a higher transcript expression level than the other ICMT present in Arabidopsis (At5g23320). Analysis of ICMT RNAi lines suggests that this protein is involved in flower and stem development.
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    Genomic context

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    See ATSTE14B in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    3
    Sequence:
    Chromosome: 5; NC_003076.8 (2681996..2683780)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene E2F-associated phosphoprotein Neighboring gene TCP family transcription factor Neighboring gene Nucleotidylyl transferase superfamily protein Neighboring gene GRAM domain-containing protein / ABA-responsive protein-like protein Neighboring gene Stu1, putative (DUF789) Neighboring gene alpha-galactosidase 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Prenylcysteine alpha-carboxyl methyltransferase expression and function in Arabidopsis thaliana. Narasimha Chary S, et al. Plant J, 2002 Dec. PMID 12472689
    2. Functional analysis of Arabidopsis postprenylation CaaX processing enzymes and their function in subcellular protein targeting. Bracha-Drori K, et al. Plant Physiol, 2008 Sep. PMID 18641086, Free PMC Article
    3. Evidence for network evolution in an Arabidopsis interactome map. Arabidopsis Interactome Mapping Consortium. Science, 2011 Jul 29. PMID 21798944, Free PMC Article
    4. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. major isoprenyl cysteine methyltransferase that modulates activity of prenylated proteins
      Title: Functional analysis of Arabidopsis postprenylation CaaX processing enzymes and their function in subcellular protein targeting.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001342996.1
    NM_120917.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within flower development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of abscisic acid-activated signaling pathway NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within shoot system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Isoprenylcysteine carboxyl methyltransferase (ICMT) family
    NP_568191.1
    • ATSTE14B; CONTAINS InterPro DOMAIN/s: Isoprenylcysteine carboxyl methyltransferase (InterPro:IPR007269); BEST Arabidopsis thaliana protein match is: homolog of yeast STE14 A (TAIR:AT5G23320.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      2681996..2683780
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_120917.2 → NP_568191.1  Isoprenylcysteine carboxyl methyltransferase (ICMT) family [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568191.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q93W54, Q9FTA1
      UniProtKB/TrEMBL
      A0A178UID5, A0A5S9Y2G9, A0A654FZI6
      Conserved Domains (1) summary
      COG2020
      Location:16 → 196
      STE14; Protein-S-isoprenylcysteine O-methyltransferase Ste14 [Posttranslational modification, protein turnover, chaperones]

    2. NM_001342996.1 → NP_001331317.1  Isoprenylcysteine carboxyl methyltransferase (ICMT) family [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q93W54, Q9FTA1
      UniProtKB/TrEMBL
      A0A178UID5, A0A5S9Y2G9, A0A654FZI6
      Conserved Domains (1) summary
      COG2020
      Location:16 → 196
      STE14; Protein-S-isoprenylcysteine O-methyltransferase Ste14 [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q93W54.1

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