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    TOPP4 type one serine/threonine protein phosphatase 4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818571, updated on 18-Sep-2024

    Summary

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    Official Symbol
    TOPP4
    Official Full Name
    type one serine/threonine protein phosphatase 4
    Primary source
    TAIR:AT2G39840
    Locus tag
    AT2G39840
    See related
    Araport:AT2G39840
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    type one serine/threonine protein phosphatase 4
    Summary
    Encodes the catalytic subunit of a Type 1 phosphoprotein Ser/Thr phosphatase, expressed in roots, shoots and flowers.
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    Genomic context

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    See TOPP4 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    4
    Sequence:
    Chromosome: 2; NC_003071.7 (16627216..16629412)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene ubiquitin-protein ligase Neighboring gene Translation initiation factor IF6 Neighboring gene DA1-related protein 2 Neighboring gene Subtilisin-like serine endopeptidase family protein Neighboring gene Proteinase inhibitor, propeptide

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TOPP4 Regulates the Stability of PHYTOCHROME INTERACTING FACTOR5 during Photomorphogenesis in Arabidopsis. Yue J, et al. Plant Physiol, 2016 Mar. PMID 26704640, Free PMC Article
    2. TYPE-ONE PROTEIN PHOSPHATASE4 regulates pavement cell interdigitation by modulating PIN-FORMED1 polarity and trafficking in Arabidopsis. Guo X, et al. Plant Physiol, 2015 Mar. PMID 25560878, Free PMC Article
    3. Type one protein phosphatase regulates fixed-carbon starvation-induced autophagy in Arabidopsis. Wang Q, et al. Plant Cell, 2022 Oct 27. PMID 35961047, Free PMC Article
    4. Role of Protein Phosphatase1 Regulatory Subunit3 in Mediating the Abscisic Acid Response. Zhang J, et al. Plant Physiol, 2020 Nov. PMID 32948668, Free PMC Article
    5. Arabidopsis DELLA protein degradation is controlled by a type-one protein phosphatase, TOPP4. Qin Q, et al. PLoS Genet, 2014 Jul. PMID 25010794, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. outline a novel phytochrome signaling mechanism by which TOPP4-mediated dephosphorylation of PIF5 attenuates phytochrome-dependent light responses
      Title: TOPP4 Regulates the Stability of PHYTOCHROME INTERACTING FACTOR5 during Photomorphogenesis in Arabidopsis.
    2. TOPP4-regulated PIN1 polar targeting through direct dephosphorylation is crucial for pavement cell morphogenesis in the Arabidopsis leaf.
      Title: TYPE-ONE PROTEIN PHOSPHATASE4 regulates pavement cell interdigitation by modulating PIN-FORMED1 polarity and trafficking in Arabidopsis.
    3. These studies provide direct evidence for a crucial role of protein dephosphorylation mediated by TOPP4 in the GA signaling pathway.
      Title: Arabidopsis DELLA protein degradation is controlled by a type-one protein phosphatase, TOPP4.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_129543.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within dephosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within gibberellic acid mediated signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within protein dephosphorylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within protein phosphorylation IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within red light signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within red light signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein phosphatase type 1 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    type one serine/threonine protein phosphatase 4
    NP_181514.1
    • type one serine/threonine protein phosphatase 4 (TOPP4); CONTAINS InterPro DOMAIN/s: Metallophosphoesterase (InterPro:IPR004843), Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase (InterPro:IPR006186); BEST Arabidopsis thaliana protein match is: type one serine/threonine protein phosphatase 2 (TAIR:AT5G59160.3); Has 7176 Blast hits to 6978 proteins in 618 species: Archae - 78; Bacteria - 533; Metazoa - 2415; Fungi - 1410; Plants - 987; Viruses - 16; Other Eukaryotes - 1737 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      16627216..16629412
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_129543.3 → NP_181514.1  type one serine/threonine protein phosphatase 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_181514.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P48484, Q147H5
      UniProtKB/TrEMBL
      A0A178VUA1, A0A5S9X5I6
      Conserved Domains (1) summary
      cd07414
      Location:18 → 308
      MPP_PP1_PPKL; PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P48484.1

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