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    PDE135 Xanthine/uracil permease family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 817192, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PDE135
    Official Full Name
    Xanthine/uracil permease family protein
    Primary source
    TAIR:AT2G26510
    Locus tag
    AT2G26510
    See related
    Araport:AT2G26510
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    NAT3; nucleobase ascorbate transporter 3; pigment defective embryo 135; T9J22.18; T9J22_18
    Summary
    Encodes a plasma-membrane localized nucleobase transporter capable of transporting adenine, guanine, uracil and hypoxanthine. Likely to be a proton-nucleobase symporter.
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    Genomic context

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    See PDE135 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    13
    Sequence:
    Chromosome: 2; NC_003071.7 (11273842..11277783)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Transducin/WD40 repeat-like superfamily protein Neighboring gene cytochrome b6f complex subunit (petM) Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Biochemical characterization and structure-function relationship of two plant NCS2 proteins, the nucleobase transporters NAT3 and NAT12 from Arabidopsis thaliana. Niopek-Witz S, et al. Biochim Biophys Acta, 2014 Dec. PMID 25135661
    2. Novel Aquaporin Regulatory Mechanisms Revealed by Interactomics. Bellati J, et al. Mol Cell Proteomics, 2016 Nov. PMID 27609422, Free PMC Article
    3. Arabidopsis plasmodesmal proteome. Fernandez-Calvino L, et al. PLoS One, 2011 Apr 20. PMID 21533090, Free PMC Article
    4. Putative glycosyltransferases and other plant Golgi apparatus proteins are revealed by LOPIT proteomics. Nikolovski N, et al. Plant Physiol, 2012 Oct. PMID 22923678, Free PMC Article
    5. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001202680.1
    NM_128208.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables adenine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables guanine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables solute:monoatomic cation symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables uracil transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within adenine import across plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within guanine import across plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within hypoxanthine transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within uracil import across plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasmodesma HDA PubMed 

    General protein information

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    Preferred Names
    Xanthine/uracil permease family protein
    NP_001189609.1
    • pigment defective embryo 135 (PDE135); FUNCTIONS IN: transmembrane transporter activity; INVOLVED IN: transport, transmembrane transport; LOCATED IN: membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Xanthine/uracil/vitamin C permease (InterPro:IPR006043); BEST Arabidopsis thaliana protein match is: Xanthine/uracil permease family protein (TAIR:AT2G05760.1).
    NP_180219.1
    • pigment defective embryo 135 (PDE135); FUNCTIONS IN: transmembrane transporter activity; INVOLVED IN: transport, transmembrane transport; LOCATED IN: plasma membrane, membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Xanthine/uracil/vitamin C permease (InterPro:IPR006043); BEST Arabidopsis thaliana protein match is: Xanthine/uracil permease family protein (TAIR:AT2G34190.1); Has 9126 Blast hits to 9110 proteins in 1899 species: Archae - 65; Bacteria - 7470; Metazoa - 356; Fungi - 126; Plants - 439; Viruses - 1; Other Eukaryotes - 669 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      11273842..11277783
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001336072.1 → NP_001325095.1  Xanthine/uracil permease family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B238
      Conserved Domains (1) summary
      cl23746
      Location:55 → 409
      Xan_ur_permease; Permease family

    2. NM_128208.5 → NP_180219.1  Xanthine/uracil permease family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_180219.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O48718, Q8GZD4
      UniProtKB/TrEMBL
      A0A178VZK9, A0A5S9X1P8
      Conserved Domains (2) summary
      pfam00860
      Location:55 → 461
      Xan_ur_permease; Permease family
      cl23746
      Location:52 → 505
      HCO3_cotransp; HCO3- transporter family

    3. NM_001202680.1 → NP_001189609.1  Xanthine/uracil permease family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001189609.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4IUL2
      Conserved Domains (1) summary
      cl23746
      Location:52 → 385
      HCO3_cotransp; HCO3- transporter family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8GZD4.2

    Gene LinkOut

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