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    DRIP2 DREB2A-interacting protein 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 817608, updated on 18-Sep-2024

    Summary

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    Official Symbol
    DRIP2
    Official Full Name
    DREB2A-interacting protein 2
    Primary source
    TAIR:AT2G30580
    Locus tag
    AT2G30580
    See related
    Araport:AT2G30580
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    BMI1A; DREB2A-interacting protein 2; T6B20.7; T6B20_7
    Summary
    Encodes a C3HC4 RING-domain-containing ubiquitin E3 ligase capable of interacting with DREB2A. DRIP2 seems to be involved in regulating stress-related transcriptional changes and drought tolerance.
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    Genomic context

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    See DRIP2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    7
    Sequence:
    Chromosome: 2; NC_003071.7 (13025911..13030661)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene photosystem II reaction center W Neighboring gene los glycosyltransferase 5 Neighboring gene WRKY DNA-binding protein 21 Neighboring gene BTB/POZ domain-containing protein Neighboring gene F-box/LRR protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome-wide association study identifies a novel BMI1A QTL allele that confers FLC expression diversity in Arabidopsis thaliana. Wang X, et al. J Exp Bot, 2024 Feb 2. PMID 36995968
    2. The Arabidopsis Polycomb Repressive Complex 1 (PRC1) Components AtBMI1A, B, and C Impact Gene Networks throughout All Stages of Plant Development. Merini W, et al. Plant Physiol, 2017 Jan. PMID 27837089, Free PMC Article
    3. Arabidopsis DREB2A-interacting proteins function as RING E3 ligases and negatively regulate plant drought stress-responsive gene expression. Qin F, et al. Plant Cell, 2008 Jun. PMID 18552202, Free PMC Article
    4. The repressive role of Arabidopsis H2A.Z in transcriptional regulation depends on AtBMI1 activity. Gómez-Zambrano Á, et al. Nat Commun, 2019 Jun 27. PMID 31249301, Free PMC Article
    5. CrY2H-seq: a massively multiplexed assay for deep-coverage interactome mapping. Wanamaker SA, et al. Nat Methods, 2017 Aug. PMID 28650476, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Genome-wide association study identifies a novel BMI1A QTL allele that confers FLC expression diversity in Arabidopsis thaliana.
      Title: Genome-wide association study identifies a novel BMI1A QTL allele that confers FLC expression diversity in Arabidopsis thaliana.
    2. H2A.Z can be monoubiquitinated by the PRC1 components AtBMI1A/B/C.
      Title: The repressive role of Arabidopsis H2A.Z in transcriptional regulation depends on AtBMI1 activity.
    3. BMI1a expression and role in the plant development
      Title: The Arabidopsis Polycomb Repressive Complex 1 (PRC1) Components AtBMI1A, B, and C Impact Gene Networks throughout All Stages of Plant Development.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001336273.1
    NM_001336274.1
    NM_128610.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein autoubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to water deprivation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    DREB2A-interacting protein 2
    NP_565702.1
    • DREB2A-interacting protein 2 (DRIP2); CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type, conserved site (InterPro:IPR017907), Zinc finger, RING-type (InterPro:IPR001841), Zinc finger, C3HC4 RING-type (InterPro:IPR018957); BEST Arabidopsis thaliana protein match is: DREB2A-interacting protein 1 (TAIR:AT1G06770.1); Has 1631 Blast hits to 1626 proteins in 163 species: Archae - 0; Bacteria - 2; Metazoa - 1227; Fungi - 58; Plants - 232; Viruses - 0; Other Eukaryotes - 112 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      13025911..13030661
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_128610.3 → NP_565702.1  DREB2A-interacting protein 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565702.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O04337, Q94AY3
      UniProtKB/TrEMBL
      A0A178VRI3, A0A5S9X2M6, A0A7G2EGC6
      Conserved Domains (3) summary
      cd00162
      Location:20 → 60
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      cd17087
      Location:310 → 412
      RAWUL_DRIP_like; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in DREB2A-interacting protein (DRIP) and similar proteins
      cl17238
      Location:19 → 61
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    2. NM_001336273.1 → NP_001323803.1  DREB2A-interacting protein 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O04337, Q94AY3
      UniProtKB/TrEMBL
      A0A178VRI3, A0A5S9X2M6, A0A7G2EGC6
      Conserved Domains (3) summary
      cd00162
      Location:20 → 60
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      cd17087
      Location:310 → 412
      RAWUL_DRIP_like; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in DREB2A-interacting protein (DRIP) and similar proteins
      cl17238
      Location:19 → 61
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    3. NM_001336274.1 → NP_001323802.1  DREB2A-interacting protein 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AY60, A0A7G2EGC6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q94AY3.1

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