BRM transcription regulatory protein SNF2 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: BRM
Official Full Name: transcription regulatory protein SNF2
Primary source: TAIR:AT2G46020
Locus tag: AT2G46020
See related: Araport:AT2G46020
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ARABIDOPSIS THALIANA BRAHMA; ATBRM; BRAHMA; CHA2; CHR2; CHROMATIN REMODELING 2; T3F17.33
Summary: Encodes a SWI/SNF chromatin remodeling ATPase that upregulates transcription of all three CUC genes and is involved in the formation and/or maintenance of boundary cells during embryogenesis. Also mediates repression of expression of seed storage proteins in vegetative tissues. Interacts strongly with AtSWI3C, also with AtSWI3B, but not with AtSWI3A or AtSWI3D.
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Genomic context

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See BRM in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 15

Sequence:: Chromosome: 2; NC_003071.7 (18922533..18932055)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Transcription elongator SPT6L regulates the occupancies of the SWI2/SNF2 chromatin remodelers SYD/BRM and nucleosomes at transcription start sites in Arabidopsis.
Title: Transcription elongator SPT6L regulates the occupancies of the SWI2/SNF2 chromatin remodelers SYD/BRM and nucleosomes at transcription start sites in Arabidopsis.
The chromatin remodelling ATPase BRAHMA interacts with GATA-family transcription factor GNC to regulate flowering time in Arabidopsis.
Title: The chromatin remodelling ATPase BRAHMA interacts with GATA-family transcription factor GNC to regulate flowering time in Arabidopsis.
Bromodomain-containing proteins BRD1, BRD2, and BRD13 are core subunits of SWI/SNF complexes and vital for their genomic targeting in Arabidopsis.
Title: Bromodomain-containing proteins BRD1, BRD2, and BRD13 are core subunits of SWI/SNF complexes and vital for their genomic targeting in Arabidopsis.
26S proteasome limits chromatin opening by BRM in conjunction with histone hyperacetylation to maintain chromatin stability and avoid DSB formation under high boron conditions.
Title: Proteasomal degradation of BRAHMA promotes Boron tolerance in Arabidopsis.
study uncovers pri-miRNAs as a substrate of CHR2, and an additional regulatory layer upstream of Microprocessor activity to control miRNA accumulation
Title: SWI2/SNF2 ATPase CHR2 remodels pri-miRNAs via Serrate to impede miRNA production.
data indicate that the chromatin-remodeling enzyme BRM modulates PORC expression through interacting with PIF1, providing a novel regulatory mechanism by which plants fine-tune chlorophyll biosynthesis
Title: The SWI2/SNF2 Chromatin-Remodeling ATPase BRAHMA Regulates Chlorophyll Biosynthesis in Arabidopsis.
Data show that mutants of Brahma (BRM) and AtMMS21 displayed a similar defect in root development.
Title: A SUMO Ligase AtMMS21 Regulates the Stability of the Chromatin Remodeler BRAHMA in Root Development.
BRM and SWN act antagonistically at the nucleosome level to fine-tune the temporal expression of miR156 to regulate vegetative phase change in Arabidopsis.
Title: Regulation of Vegetative Phase Change by SWI2/SNF2 Chromatin Remodeling ATPase BRAHMA.
while BRM predominantly regulates its target genes by binding to their promoters, many genes are bound by BRM at their 3 ends. These 3 regions serve as promoters of non-coding transcription extensively regulated by BRM.
Title: Arabidopsis SWI/SNF chromatin remodeling complex binds both promoters and terminators to regulate gene expression.
Genome-wide analyses showed that REF6 colocalizes with BRM at many genomic sites with the CTCTGYTY motif. Loss of REF6 results in decreased BRM occupancy at BRM-REF6 co-targets
Title: Concerted genomic targeting of H3K27 demethylase REF6 and chromatin-remodeling ATPase BRM in Arabidopsis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_001337166.1

Supported by ESTs:

NM_001337168.1

Supported by ESTs:

NM_001337169.1

Supported by ESTs:

NM_130165.3

Supported by ESTs:

NM_201966.2

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables ATP-dependent chromatin remodeler activity	IEA Inferred from Electronic Annotation more info
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within epigenetic regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within formation of plant organ boundary	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within organ boundary specification between lateral organs and the meristem	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of cellular response to heat	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of miRNA processing	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within root meristem growth	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within vegetative phase change	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: transcription regulatory protein SNF2

NP_001318432.1

BRAHMA (BRM); FUNCTIONS IN: helicase activity, transcription regulator activity, DNA binding, ATP binding; INVOLVED IN: ATP-dependent chromatin remodeling, organ boundary specification between lateral organs and the meristem, regulation of gene expression, epigenetic; LOCATED IN: cytosol, nucleus, chromatin remodeling complex; EXPRESSED IN: 31 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Glutamine-Leucine-Glutamine, QLQ (InterPro:IPR014978), DEAD-like helicase, N-terminal (InterPro:IPR014001), DNA/RNA helicase, C-terminal (InterPro:IPR001650), Helicase, superfamily 1/2, ATP-binding domain (InterPro:IPR014021), Bromodomain (InterPro:IPR001487), SNF2-related (InterPro:IPR000330); BEST Arabidopsis thaliana protein match is: P-loop containing nucleoside triphosphate hydrolases superfamily protein (TAIR:AT2G28290.3); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NP_973695.1

BRAHMA (BRM); FUNCTIONS IN: helicase activity, transcription regulator activity, DNA binding, ATP binding; INVOLVED IN: ATP-dependent chromatin remodeling, organ boundary specification between lateral organs and the meristem, regulation of gene expression, epigenetic; LOCATED IN: cytosol, nucleus, chromatin remodeling complex; EXPRESSED IN: 31 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: DEAD-like helicase, N-terminal (InterPro:IPR014001), DNA/RNA helicase, C-terminal (InterPro:IPR001650), Helicase, superfamily 1/2, ATP-binding domain (InterPro:IPR014021), Bromodomain (InterPro:IPR001487), SNF2-related (InterPro:IPR000330); BEST Arabidopsis thaliana protein match is: P-loop containing nucleoside triphosphate hydrolases superfamily protein (TAIR:AT2G28290.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

18922533..18932055

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001337167.1 → NP_001323762.1 transcription regulatory protein SNF2 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

O82366, O82780, Q6EVK6

UniProtKB/TrEMBL

A0A178VVS7
NM_001337166.1 → NP_001318432.1 transcription regulatory protein SNF2 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178VVS7
NM_001337168.1 → NP_001323760.1 transcription regulatory protein SNF2 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

O82366, O82780, Q6EVK6

UniProtKB/TrEMBL

A0A178VVS7
NM_001337169.1 → NP_001323761.1 transcription regulatory protein SNF2 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178VVS7
NM_201966.2 → NP_973695.1 transcription regulatory protein SNF2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_973695.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O82366, O82780, Q6EVK6

UniProtKB/TrEMBL

A0A178VVS7

Conserved Domains (5) summary

smart00297
Location:1900 → 2004

BROMO; bromo domain

smart00951
Location:462 → 497

QLQ; QLQ is named after the conserved Gln, Leu, Gln motif

cd00046
Location:1001 → 1140

DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.

pfam00176
Location:984 → 1290

SNF2_N; SNF2 family N-terminal domain

pfam00271
Location:1307 → 1422

Helicase_C; Helicase conserved C-terminal domain
NM_130165.3 → NP_182126.2 transcription regulatory protein SNF2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_182126.2

Status: REVIEWED

UniProtKB/TrEMBL

A0A178VVS7

Conserved Domains (5) summary

smart00297
Location:1899 → 2003

BROMO; bromo domain

smart00951
Location:462 → 497

QLQ; QLQ is named after the conserved Gln, Leu, Gln motif

cd00046
Location:1001 → 1139

DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.

pfam00176
Location:984 → 1289

SNF2_N; SNF2 family N-terminal domain

pfam00271
Location:1306 → 1421

Helicase_C; Helicase conserved C-terminal domain