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    TIL2 DNA polymerase epsilon catalytic subunit [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 817254, updated on 18-Sep-2024

    Summary

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    Official Symbol
    TIL2
    Official Full Name
    DNA polymerase epsilon catalytic subunit
    Primary source
    TAIR:AT2G27120
    Locus tag
    AT2G27120
    See related
    Araport:AT2G27120
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    POL2B; T20P8.17; T20P8_17; TILTED 2
    Summary
    Encodes a protein with similarity to DNA polymerase epsilon catalytic subunit. Based on yeast two hybrid analysis, not predicted to be a subunit of the DNA polymerase epsilon complex. No phenotype observed in homozygous mutant embryos or plants but in combination with TIL1-1/til1-1 heterozygotes arrest earlier than til1 homozygotes suggesting TIL2 functions redundantly with TIL1.
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    Genomic context

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    See TIL2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    49
    Sequence:
    Chromosome: 2; NC_003071.7 (11581214..11594397)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene C2H2 zinc-finger protein SERRATE (SE) Neighboring gene FAR1-related sequence 3 Neighboring gene Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein Neighboring gene HSP20-like chaperones superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Function of the Plant DNA Polymerase Epsilon in Replicative Stress Sensing, a Genetic Analysis. Pedroza-García JA, et al. Plant Physiol, 2017 Mar. PMID 28153919, Free PMC Article
    2. Genetic analysis of two Arabidopsis DNA polymerase epsilon subunits during early embryogenesis. Ronceret A, et al. Plant J, 2005 Oct. PMID 16212602
    3. Interactions between the cell cycle and embryonic patterning in Arabidopsis uncovered by a mutation in DNA polymerase epsilon. Jenik PD, et al. Plant Cell, 2005 Dec. PMID 16278345, Free PMC Article
    4. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results indicate that the role of Pol epsilon in replicative stress sensing is conserved in plants.
      Title: Function of the Plant DNA Polymerase Epsilon in Replicative Stress Sensing, a Genetic Analysis.
    2. role of DNA polymerase epsilon during gametophyte and seed development in A. thaliana, encoded by POL2a and POl2b, with a main regulatory subunit DPB2, is reported
      Title: Genetic analysis of two Arabidopsis DNA polymerase epsilon subunits during early embryogenesis.
    Submit: New GeneRIF Correction

    General gene information

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    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-directed DNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of epsilon DNA polymerase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of epsilon DNA polymerase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    DNA polymerase epsilon catalytic subunit
    NP_180280.2
    • TILTED 2 (TIL2); FUNCTIONS IN: DNA-directed DNA polymerase activity, DNA binding, nucleotide binding, zinc ion binding, nucleic acid binding; INVOLVED IN: DNA replication; EXPRESSED IN: leaf whorl, sperm cell, male gametophyte, flower, pollen tube; EXPRESSED DURING: M germinated pollen stage, 4 anthesis; CONTAINS InterPro DOMAIN/s: DNA polymerase, family B (InterPro:IPR022762), DNA-directed DNA polymerase, family B, exonuclease domain (InterPro:IPR006133), Domain of unknown function DUF1744 (InterPro:IPR013697), Polynucleotidyl transferase, ribonuclease H fold (InterPro:IPR012337), DNA-directed DNA polymerase, family B, conserved region (InterPro:IPR006134); BEST Arabidopsis thaliana protein match is: DNA polymerase epsilon catalytic subunit (TAIR:AT1G08260.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      11581214..11594397
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001336102.1 → NP_001325161.1  DNA polymerase epsilon catalytic subunit [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B2E1, A0A654EWK3

    2. NM_128270.3 → NP_180280.2  DNA polymerase epsilon catalytic subunit [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_180280.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4IFN6, Q9ZVC8
      UniProtKB/TrEMBL
      A0A654EWK3
      Conserved Domains (4) summary
      cd05779
      Location:232 → 436
      DNA_polB_epsilon_exo; DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase epsilon, a family-B DNA polymerase
      cd05535
      Location:495 → 1114
      POLBc_epsilon; DNA polymerase type-B epsilon subfamily catalytic domain. Three DNA-dependent DNA polymerases type B (alpha, delta, and epsilon) have been identified as essential for nuclear DNA replication in eukaryotes. DNA polymerase (Pol) epsilon has been proposed ...
      COG0417
      Location:114 → 1125
      PolB; DNA polymerase elongation subunit (family B) [Replication, recombination and repair]
      pfam08490
      Location:1475 → 1848
      DUF1744; Domain of unknown function (DUF1744)

    3. NM_001336103.1 → NP_001325160.1  DNA polymerase epsilon catalytic subunit [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B2B9, A0A654EWK3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4IFN6.1

    Gene LinkOut

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