LIN2 Coproporphyrinogen III oxidase [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: LIN2
Official Full Name: Coproporphyrinogen III oxidase
Primary source: TAIR:AT1G03475
Locus tag: AT1G03475
See related: Araport:AT1G03475
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATCPO-I; COPROPORPHYRINOGEN III OXIDASE; CPO; F21B7.10; HEMF1; LESION INITIATION 2
Summary: Encodes coproporphyrinogen III oxidase, a key enzyme in the biosynthetic pathway of chlorophyll and heme, a tetrapyrrole pathway. Mutants express cytological and molecular markers associated with the defense responses, usually activated by pathogen infection.
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Genomic context

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See LIN2 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 8

Sequence:: Chromosome: 1; NC_003070.9 (868853..871308, complement)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LIN2 negatively regulates resistance to powdery mildew and oomycete pathogens.
Title: A mutation in a coproporphyrinogen III oxidase gene confers growth inhibition, enhanced powdery mildew resistance and powdery mildew-induced cell death in Arabidopsis.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_100230.7

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables coproporphyrinogen oxidase activity	IEA Inferred from Electronic Annotation more info
enables coproporphyrinogen oxidase activity	IGI Inferred from Genetic Interaction more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in chlorophyll biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in protoporphyrinogen IX biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within tetrapyrrole biosynthetic process	IC Inferred by Curator more info

Component	Evidence Code	Pubs
located_in apoplast	HDA more info	PubMed
located_in chloroplast	HDA more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in chloroplast stroma	HDA more info	PubMed
located_in extracellular region	HDA more info	PubMed
located_in plastid	IDA Inferred from Direct Assay more info

General protein information

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Preferred Names: Coproporphyrinogen III oxidase

NP_171847.4

LESION INITIATION 2 (LIN2); FUNCTIONS IN: coproporphyrinogen oxidase activity; INVOLVED IN: tetrapyrrole biosynthetic process; LOCATED IN: apoplast, chloroplast stroma, chloroplast, plastid; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Coproporphyrinogen III oxidase (InterPro:IPR001260), Coproporphyrinogen III oxidase, conserved site (InterPro:IPR018375); BEST Arabidopsis thaliana protein match is: Coproporphyrinogen III oxidase (TAIR:AT4G03205.1); Has 4884 Blast hits to 4875 proteins in 1228 species: Archae - 0; Bacteria - 2144; Metazoa - 115; Fungi - 160; Plants - 86; Viruses - 0; Other Eukaryotes - 2379 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

868853..871308 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_100230.7 → NP_171847.4 Coproporphyrinogen III oxidase [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_171847.4

Status: REVIEWED

UniProtKB/Swiss-Prot

Q546I5, Q94JR5, Q9LR75

UniProtKB/TrEMBL

A0A178WIW9, A0A5S9SDB9

Conserved Domains (1) summary

PLN02873
Location:116 → 386

PLN02873; coproporphyrinogen-III oxidase