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    HEMA2 Glutamyl-tRNA reductase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837528, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HEMA2
    Official Full Name
    Glutamyl-tRNA reductase family protein
    Primary source
    TAIR:AT1G09940
    Locus tag
    AT1G09940
    See related
    Araport:AT1G09940
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F21M12.33; F21M12_33
    Summary
    Encodes glutamyl-tRNA reductase. Involved in heme biosynthesis in non-photosynthetic tissues and induced by oxidative stress in photosynthetic tissues to supply heme for defensive hemoproteins
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    Genomic context

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    See HEMA2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    3
    Sequence:
    Chromosome: 1; NC_003070.9 (3236908..3239554, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Phosphoglycerate mutase family protein Neighboring gene Phosphoglycerate mutase family protein Neighboring gene RESPONSE TO ABA AND SALT 1 Neighboring gene sucrose transporter 4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Induction of isoforms of tetrapyrrole biosynthetic enzymes, AtHEMA2 and AtFC1, under stress conditions and their physiological functions in Arabidopsis. Nagai S, et al. Plant Physiol, 2007 Jun. PMID 17416636, Free PMC Article
    2. A second and differentially expressed glutamyl-tRNA reductase gene from Arabidopsis thaliana. Kumar AM, et al. Plant Mol Biol, 1996 Feb. PMID 8605295
    3. In-depth temporal transcriptome profiling reveals a crucial developmental switch with roles for RNA processing and organelle metabolism that are essential for germination in Arabidopsis. Narsai R, et al. Plant Physiol, 2011 Nov. PMID 21908688, Free PMC Article
    4. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. induced in photosynthetic tissues under oxidative conditions to supply heme for defensive hemoproteins outside plastids
      Title: Induction of isoforms of tetrapyrrole biosynthetic enzymes, AtHEMA2 and AtFC1, under stress conditions and their physiological functions in Arabidopsis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    NM_100868.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables NADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutamyl-tRNA reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutamyl-tRNA reductase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chlorophyll biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within heme biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within porphyrin-containing compound biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in protoporphyrinogen IX biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to oxidative stress IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within tetrapyrrole biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plastid HDA PubMed 

    General protein information

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    Preferred Names
    Glutamyl-tRNA reductase family protein
    NP_172465.1
    • HEMA2; FUNCTIONS IN: glutamyl-tRNA reductase activity; INVOLVED IN: response to oxidative stress, heme biosynthetic process, tetrapyrrole biosynthetic process, porphyrin biosynthetic process; LOCATED IN: cytoplasm; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase (InterPro:IPR006151), Tetrapyrrole biosynthesis, glutamyl-tRNA reductase, conserved site (InterPro:IPR018214), Tetrapyrrole biosynthesis, glutamyl-tRNA reductase, C-terminal (InterPro:IPR015896), Tetrapyrrole biosynthesis, glutamyl-tRNA reductase (InterPro:IPR000343), Tetrapyrrole biosynthesis, glutamyl-tRNA reductase, N-terminal (InterPro:IPR015895); BEST Arabidopsis thaliana protein match is: Glutamyl-tRNA reductase family protein (TAIR:AT1G58290.1); Has 5044 Blast hits to 5020 proteins in 1819 species: Archae - 226; Bacteria - 3662; Metazoa - 1; Fungi - 0; Plants - 221; Viruses - 0; Other Eukaryotes - 934 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      3236908..3239554 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_100868.3 → NP_172465.1  Glutamyl-tRNA reductase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_172465.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O04950, P49294, Q0WQP1, Q4V3B7
      UniProtKB/TrEMBL
      A0A5S9TJA0
      Conserved Domains (1) summary
      PLN00203
      Location:1 → 519
      PLN00203; glutamyl-tRNA reductase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49294.2

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