U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CLV1 Leucine-rich receptor-like protein kinase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 843915, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    CLV1
    Official Full Name
    Leucine-rich receptor-like protein kinase family protein
    Primary source
    TAIR:AT1G75820
    Locus tag
    AT1G75820
    See related
    Araport:AT1G75820
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATCLV1; CLAVATA 1; CLV1 RECEPTOR KINASE PRECURSOR; FAS3; FASCIATA 3; FLO5; FLOWER DEVELOPMENT 5; T4O12.5; T4O12_5
    Summary
    Putative receptor kinase with an extracellular leucine-rich domain. Controls shoot and floral meristem size, and contributes to establish and maintain floral meristem identity. Negatively regulated by KAPP (kinase-associated protein phosphatase). CLV3 peptide binds directly CLV1 ectodomain.
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See CLV1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    2
    Sequence:
    Chromosome: 1; NC_003070.9 (28463344..28466971, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Pathogenesis-related thaumatin superfamily protein Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The CLAVATA1 gene encodes a putative receptor kinase that controls shoot and floral meristem size in Arabidopsis. Clark SE, et al. Cell, 1997 May 16. PMID 9160749
    2. Genetic and physical characterization of a region of Arabidopsis chromosome 1 containing the CLAVATA1 gene. Williams RW, et al. Plant Mol Biol, 1999 Jan. PMID 10080719
    3. CLAVATA1 controls distinct signaling outputs that buffer shoot stem cell proliferation through a two-step transcriptional compensation loop. Nimchuk ZL. PLoS Genet, 2017 Mar. PMID 28355208, Free PMC Article
    4. Plant stem cell maintenance by transcriptional cross-regulation of related receptor kinases. Nimchuk ZL, et al. Development, 2015 Mar 15. PMID 25758219, Free PMC Article
    5. CLE-CLAVATA1 peptide-receptor signaling module regulates the expansion of plant root systems in a nitrogen-dependent manner. Araya T, et al. Proc Natl Acad Sci U S A, 2014 Feb 4. PMID 24449877, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TPLATE complex-dependent endocytosis attenuates CLAVATA1 signaling for shoot apical meristem maintenance.
      Title: TPLATE complex-dependent endocytosis attenuates CLAVATA1 signaling for shoot apical meristem maintenance.
    2. CLE3 and its homologs share overlapping functions in the modulation of lateral root formation through CLV1 and BAM1 in Arabidopsis thaliana.
      Title: CLE3 and its homologs share overlapping functions in the modulation of lateral root formation through CLV1 and BAM1 in Arabidopsis thaliana.
    3. The S-acylated form of C4 interacts with CLAVATA 1 (CLV1), an important receptor kinase in meristem maintenance, and consequentially affects the expression of WUSCHEL, a major target of CLV1.
      Title: S-acylation of a geminivirus C4 protein is essential for regulating the CLAVATA pathway in symptom determination.
    4. CLV1 and GCN5 are regulators of apical-basal and mediolateral polarity of the Arabidopsis gynoecium.
      Title: Synergistic action of GCN5 and CLAVATA1 in the regulation of gynoecium development in Arabidopsis thaliana.
    5. CLV signaling involves the secretion of the CLV3 peptide and its perception by a number of Leucine-Rich-Repeat (LRR) receptors, including the receptor-like kinase CLV1 and the receptor-like protein CLV2 coupled with the CORYNE (CRN) pseudokinase. CLV2, and its maize ortholog FASCIATED EAR2 (FEA2) appear to function in signaling by CLV3 and several related CLV3/EMBRYO-SURROUNDING REGION (CLE) peptide ligands.
      Title: The CLAVATA receptor FASCIATED EAR2 responds to distinct CLE peptides by signaling through two downstream effectors.
    6. CLV1 and CLV2, two receptors involved in CLV3 perception during plant development, contribute to bacterial wilt through a signalling pathway involving the miR169/NF-YA module.
      Title: Arabidopsis CLAVATA1 and CLAVATA2 receptors contribute to Ralstonia solanacearum pathogenicity through a miR169-dependent pathway.
    7. Data indicate a role for transmembrane receptor kinase CLV1 (CLV1) separable from other stem cell receptors and provides a framework for dissecting the signaling outputs in stem cell regulation.
      Title: CLAVATA1 controls distinct signaling outputs that buffer shoot stem cell proliferation through a two-step transcriptional compensation loop.
    8. CLV3 ligand/CLV1 receptor system initiates a signaling cascade that elevates cytosolic Ca(2+). This cytosolic secondary messenger is involved in the signal transduction cascade linking CLV3/CLV1 to control of gene expression and stem cell fate in the shoot apical meristem (SAM).
      Title: The CLAVATA signaling pathway mediating stem cell fate in shoot meristems requires Ca(2+) as a secondary cytosolic messenger.
    9. signals from the CLV transduction pathway reach the GCN5-containing complexes in the nucleus and alter the histone acetylation status of ethylene-responsive genes.
      Title: Synergistic action of histone acetyltransferase GCN5 and receptor CLAVATA1 negatively affects ethylene responses in Arabidopsis thaliana.
    10. The interplay between cytokinin signaling, WUS/CLV feedback loop and boundary signals can account for positioning of the WUS expression in the process of Arabidopsis thaliana shoot apical meristem patterning.
      Title: Centering the Organizing Center in the Arabidopsis thaliana Shoot Apical Meristem by a Combination of Cytokinin Signaling and Self-Organization.
    Submit: New GeneRIF Correction See all GeneRIFs (22)

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    NM_106232.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables receptor serine/threonine kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within peptidyl-serine autophosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of meristem structural organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within signal complex assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in plant-type vacuole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasmodesma IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    Leucine-rich receptor-like protein kinase family protein
    NP_177710.1
    • CLAVATA 1 (CLV1); CONTAINS InterPro DOMAIN/s: Serine/threonine-protein kinase domain (InterPro:IPR002290), Leucine-rich repeat-containing N-terminal domain, type 2 (InterPro:IPR013210), Leucine-rich repeat (InterPro:IPR001611), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase-like domain (InterPro:IPR011009), Protein kinase, catalytic domain (InterPro:IPR000719), Leucine-rich repeat, typical subtype (InterPro:IPR003591), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635); BEST Arabidopsis thaliana protein match is: Leucine-rich receptor-like protein kinase family protein (TAIR:AT5G65700.2); Has 209359 Blast hits to 134993 proteins in 4611 species: Archae - 138; Bacteria - 19949; Metazoa - 62202; Fungi - 10385; Plants - 91018; Viruses - 406; Other Eukaryotes - 25261 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      28463344..28466971 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_106232.4 → NP_177710.1  Leucine-rich receptor-like protein kinase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_177710.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O04380, Q56Y00, Q9LQT2, Q9SYQ8
      UniProtKB/TrEMBL
      A0A178W3N9, A0A384L048, C0LGJ2
      Conserved Domains (2) summary
      PLN00113
      Location:22 → 973
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00033
      Location:267 → 290
      LRR_RI; leucine-rich repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SYQ8.3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools