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    PWP2 periodic tryptophan protein 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 838115, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PWP2
    Official Full Name
    periodic tryptophan protein 2
    Primary source
    TAIR:AT1G15440
    Locus tag
    AT1G15440
    See related
    Araport:AT1G15440
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    (PERIODIC TRYPTOPHAN PROTEIN 2; ATPWP2; F9L1.40; F9L1_40; periodic tryptophan protein 2; PERIODIC TRYPTOPHAN PROTEIN 2
    Summary
    Encodes a nucleolar protein that is a ribosome biogenesis co-factor. Mutants display aberrant RNA processing and female gametophyte development.
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    Genomic context

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    See PWP2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    7
    Sequence:
    Chromosome: 1; NC_003070.9 (5306027..5309558, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene aspartate-glutamate racemase family Neighboring gene late embryogenesis abundant-like protein Neighboring gene WD repeat protein Neighboring gene hypothetical protein (DUF1644) Neighboring gene tRNA-Trp Neighboring gene HCO3- transporter family

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A comparative study of the Arabidopsis thaliana guard-cell transcriptome and its modulation by sucrose. Bates GW, et al. PLoS One, 2012. PMID 23185391, Free PMC Article
    2. Detection of protein-protein interactions in plants using the transrepressive activity of the EAR motif repression domain. Matsui K, et al. Plant J, 2010 Feb. PMID 19929880
    3. 40S ribosome biogenesis co-factors are essential for gametophyte and embryo development. Missbach S, et al. PLoS One, 2013. PMID 23382868, Free PMC Article
    4. Characterization of Arabidopsis and rice DWD proteins and their roles as substrate receptors for CUL4-RING E3 ubiquitin ligases. Lee JH, et al. Plant Cell, 2008 Jan. PMID 18223036, Free PMC Article
    5. Arabidopsis DDB1-CUL4 ASSOCIATED FACTOR1 forms a nuclear E3 ubiquitin ligase with DDB1 and CUL4 that is involved in multiple plant developmental processes. Zhang Y, et al. Plant Cell, 2008 Jun. PMID 18552200, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_101414.4
    NM_202107.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within embryo sac development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within rRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of stomatal movement IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to sucrose IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Cul4-RING E3 ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    periodic tryptophan protein 2
    NP_172998.1
    • periodic tryptophan protein 2 (PWP2); FUNCTIONS IN: nucleotide binding; INVOLVED IN: biological_process unknown; LOCATED IN: CUL4 RING ubiquitin ligase complex; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), WD40 repeat, conserved site (InterPro:IPR019775), WD40 repeat (InterPro:IPR001680), Small-subunit processome, Utp12 (InterPro:IPR007148), G-protein beta WD-40 repeat, region (InterPro:IPR020472), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: Transducin/WD40 repeat-like superfamily protein (TAIR:AT1G11160.1); Has 76374 Blast hits to 32281 proteins in 860 species: Archae - 60; Bacteria - 9617; Metazoa - 31125; Fungi - 15572; Plants - 10039; Viruses - 0; Other Eukaryotes - 9961 (source: NCBI BLink).
    NP_973836.1
    • periodic tryptophan protein 2 (PWP2); FUNCTIONS IN: nucleotide binding; INVOLVED IN: biological_process unknown; LOCATED IN: CUL4 RING ubiquitin ligase complex; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), WD40 repeat, conserved site (InterPro:IPR019775), WD40 repeat (InterPro:IPR001680), Small-subunit processome, Utp12 (InterPro:IPR007148), G-protein beta WD-40 repeat, region (InterPro:IPR020472), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: Transducin/WD40 repeat-like superfamily protein (TAIR:AT1G11160.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      5306027..5309558 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_101414.4 → NP_172998.1  periodic tryptophan protein 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_172998.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4HZM8, Q8VYZ5, Q9XI24
      UniProtKB/TrEMBL
      A0A178WGT8, A0A5S9UJ78, A0A654EB48, A0A7G2DTX9
      Conserved Domains (4) summary
      cd00200
      Location:338 → 599
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:393 → 429
      7WD40; WD40 repeat [structural motif]
      pfam04003
      Location:790 → 895
      Utp12; Dip2/Utp12 Family
      cl29593
      Location:93 → 459
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_202107.1 → NP_973836.1  periodic tryptophan protein 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_973836.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WGT8, A0A5S9UJ78, A0A7G2DTX9
      Conserved Domains (5) summary
      COG2319
      Location:295 → 622
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:298 → 559
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam04003
      Location:751 → 853
      Utp12; Dip2/Utp12 Family
      sd00039
      Location:353 → 389
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:55 → 419
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VYZ5.1

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