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    HKL1 hexokinase-like 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 841468, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HKL1
    Official Full Name
    hexokinase-like 1
    Primary source
    TAIR:AT1G50460
    Locus tag
    AT1G50460
    See related
    Araport:AT1G50460
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATHKL1; F11F12.18; F11F12_18; hexokinase-like 1
    Summary
    Involved in glucose-ethylene crosstalk.
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    Genomic context

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    See HKL1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    10
    Sequence:
    Chromosome: 1; NC_003070.9 (18693644..18697709)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene RING/FYVE/PHD zinc finger superfamily protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Saccharopine dehydrogenase Neighboring gene F-box associated ubiquitination effector family protein Neighboring gene 10-formyltetrahydrofolate synthetase Neighboring gene ubiquitin-conjugating enzyme 20

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Function of Arabidopsis hexokinase-like1 as a negative regulator of plant growth. Karve A, et al. J Exp Bot, 2009. PMID 19706780, Free PMC Article
    2. Arabidopsis Hexokinase-Like1 and Hexokinase1 form a critical node in mediating plant glucose and ethylene responses. Karve A, et al. Plant Physiol, 2012 Apr. PMID 22366209, Free PMC Article
    3. Isozymes of plant hexokinase: occurrence, properties and functions. Claeyssen E, et al. Phytochemistry, 2007 Mar. PMID 17234224
    4. Functional analysis of the Hikeshi-like protein and its interaction with HSP70 in Arabidopsis. Koizumi S, et al. Biochem Biophys Res Commun, 2014 Jul 18. PMID 24942879
    5. Expression and evolutionary features of the hexokinase gene family in Arabidopsis. Karve A, et al. Planta, 2008 Aug. PMID 18481082, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HKL1 and HXK1 can interact, these two proteins likely form a critical node in Glc signaling that mediates overlapping, but also distinct, cellular responses to Glc and ethylene treatments.
      Title: Arabidopsis Hexokinase-Like1 and Hexokinase1 form a critical node in mediating plant glucose and ethylene responses.
    2. hexokinase-like1 acts as a negative regulator of plant growth.
      Title: Function of Arabidopsis hexokinase-like1 as a negative regulator of plant growth.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001333439.1
    NM_103929.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables D-glucose binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables fructokinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables glucokinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glycolytic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in hexose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular glucose homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to cold IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to osmotic stress IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to salt stress IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within root hair cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    hexokinase-like 1
    NP_175463.1
    • hexokinase-like 1 (HKL1); FUNCTIONS IN: hexokinase activity, ATP binding; INVOLVED IN: response to salt stress, response to cold, response to osmotic stress; LOCATED IN: mitochondrion, plastid; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Hexokinase, N-terminal (InterPro:IPR022672), Hexokinase, C-terminal (InterPro:IPR022673), Hexokinase (InterPro:IPR001312); BEST Arabidopsis thaliana protein match is: Hexokinase (TAIR:AT3G20040.1); Has 2396 Blast hits to 2128 proteins in 324 species: Archae - 0; Bacteria - 92; Metazoa - 1286; Fungi - 598; Plants - 287; Viruses - 0; Other Eukaryotes - 133 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      18693644..18697709
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001333438.1 → NP_001322009.1  hexokinase-like 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8ASN0

    2. NM_103929.4 → NP_175463.1  hexokinase-like 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_175463.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LPS1
      UniProtKB/TrEMBL
      A0A178W513, A0A5S9WNI8
      Conserved Domains (1) summary
      PLN02362
      Location:1 → 498
      PLN02362; hexokinase

    3. NM_001333439.1 → NP_001322008.1  hexokinase-like 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8ASQ8, A0A7G2DZZ5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LPS1.1

    Gene LinkOut

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