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    PPa1 pyrophosphorylase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 839579, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PPa1
    Official Full Name
    pyrophosphorylase 1
    Primary source
    TAIR:AT1G01050
    Locus tag
    AT1G01050
    See related
    Araport:AT1G01050
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtPPa1; pyrophosphorylase 1; T25K16.5; T25K16_5
    Summary
    Encodes a soluble protein with inorganic pyrophosphatase activity that is highly specific for Mg-inorganic pyrophosphate.
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    Genomic context

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    See PPa1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    10
    Sequence:
    Chromosome: 1; NC_003070.9 (31170..33171, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene dicer-like 1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Homeodomain-like superfamily protein Neighboring gene nodulin MtN21 /EamA-like transporter family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Oil and protein accumulation in developing seeds is influenced by the expression of a cytosolic pyrophosphatase in Arabidopsis. Meyer K, et al. Plant Physiol, 2012 Jul. PMID 22566496, Free PMC Article
    2. Crystal structures of plant inorganic pyrophosphatase, an enzyme with a moonlighting autoproteolytic activity. Grzechowiak M, et al. Biochem J, 2019 Aug 22. PMID 31371393
    3. Vacuolar H(+)-Pyrophosphatase and Cytosolic Soluble Pyrophosphatases Cooperatively Regulate Pyrophosphate Levels in Arabidopsis thaliana. Segami S, et al. Plant Cell, 2018 May. PMID 29691313, Free PMC Article
    4. Virus-induced gene silencing of plastidial soluble inorganic pyrophosphatase impairs essential leaf anabolic pathways and reduces drought stress tolerance in Nicotiana benthamiana. George GM, et al. Plant Physiol, 2010 Sep. PMID 20605913, Free PMC Article
    5. High-throughput protein localization in Arabidopsis using Agrobacterium-mediated transient expression of GFP-ORF fusions. Koroleva OA, et al. Plant J, 2005 Jan. PMID 15610358

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Crystal structures of plant inorganic pyrophosphatase, an enzyme with a moonlighting autoproteolytic activity.
      Title: Crystal structures of plant inorganic pyrophosphatase, an enzyme with a moonlighting autoproteolytic activity.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001331245.1
    NM_099987.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables inorganic diphosphate phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables inorganic diphosphate phosphatase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables inorganic diphosphate phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell wall biogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within cell wall biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lipid storage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphate-containing compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of starch metabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of starch metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within sucrose metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within sucrose metabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    pyrophosphorylase 1
    NP_171613.1
    • pyrophosphorylase 1 (PPa1); FUNCTIONS IN: inorganic diphosphatase activity; INVOLVED IN: phosphate metabolic process, metabolic process; LOCATED IN: nucleus, membrane, cytoplasm; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Inorganic pyrophosphatase (InterPro:IPR008162); BEST Arabidopsis thaliana protein match is: pyrophosphorylase 3 (TAIR:AT2G46860.1); Has 5987 Blast hits to 5987 proteins in 1845 species: Archae - 172; Bacteria - 4313; Metazoa - 247; Fungi - 261; Plants - 270; Viruses - 0; Other Eukaryotes - 724 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      31170..33171 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_099987.4 → NP_171613.1  pyrophosphorylase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_171613.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q93V56, Q9MAM9
      UniProtKB/TrEMBL
      A0A178WLC4, A0A5S9XNW6
      Conserved Domains (1) summary
      PLN02373
      Location:25 → 212
      PLN02373; soluble inorganic pyrophosphatase

    2. NM_001331245.1 → NP_001322481.1  pyrophosphorylase 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q93V56, Q9MAM9
      UniProtKB/TrEMBL
      A0A178WLC4, A0A5S9XNW6
      Conserved Domains (1) summary
      PLN02373
      Location:25 → 212
      PLN02373; soluble inorganic pyrophosphatase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q93V56.1

    Gene LinkOut

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