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    Svil supervillin [ Mus musculus (house mouse) ]

    Gene ID: 225115, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Svilprovided by MGI
    Official Full Name
    supervillinprovided by MGI
    Primary source
    MGI:MGI:2147319
    See related
    Ensembl:ENSMUSG00000024236 AllianceGenome:MGI:2147319
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    B430302E16Rik
    Summary
    Enables actin filament binding activity. Acts upstream of or within muscle cell differentiation. Located in several cellular components, including costamere; focal adhesion; and sarcolemma. Is expressed in several structures, including exoccipital bone; gut; meninges; pharyngo-tympanic tube; and skin. Human ortholog(s) of this gene implicated in myofibrillar myopathy 10. Orthologous to human SVIL (supervillin). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in bladder adult (RPKM 33.3), heart adult (RPKM 16.5) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Svil in Genome Data Viewer
    Location:
    18 A1; 18 3.02 cM
    Exon count:
    44
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (4920497..5119290)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (4920467..5119293)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene 10556 Neighboring gene predicted gene, 34269 Neighboring gene predicted gene, 41659 Neighboring gene STARR-seq mESC enhancer starr_43686 Neighboring gene STARR-seq mESC enhancer starr_43689 Neighboring gene predicted gene, 34326 Neighboring gene STARR-seq mESC enhancer starr_43691 Neighboring gene STARR-seq mESC enhancer starr_43692 Neighboring gene STARR-seq mESC enhancer starr_43693 Neighboring gene predicted gene, 53196 Neighboring gene predicted gene, 26682

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Novel γ-sarcoglycan interactors in murine muscle membranes. Smith TC, et al. Skelet Muscle, 2022 Jan 22. PMID 35065666, Free PMC Article
    2. Human genome-wide association and mouse knockout approaches identify platelet supervillin as an inhibitor of thrombus formation under shear stress. Edelstein LC, et al. Circulation, 2012 Jun 5. PMID 22550155, Free PMC Article
    3. Archvillin, a muscle-specific isoform of supervillin, is an early expressed component of the costameric membrane skeleton. Oh SW, et al. J Cell Sci, 2003 Jun 1. PMID 12711699
    4. Supervillin Is a Component of the Hair Cell's Cuticular Plate and the Head Plates of Organ of Corti Supporting Cells. Pollock LM, et al. PLoS One, 2016. PMID 27415442, Free PMC Article
    5. Gamma-sarcoglycan is required for the response of archvillin to mechanical stimulation in skeletal muscle. Spinazzola JM, et al. Hum Mol Genet, 2015 May 1. PMID 25605665, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. supervillin, an F-actin cross-linking protein, localizes to cuticular plates in hair cells of the mouse cochlea and vestibule. Supervillin localizes near the apicolateral margins within the head plates of Deiters' cells and outer pillar cells, and proximal to the apicolateral margins of inner phalangeal cells. Overall, supervillin localization suggests this protein may shape the surface structure of the organ of Corti.
      Title: Supervillin Is a Component of the Hair Cell's Cuticular Plate and the Head Plates of Organ of Corti Supporting Cells.
    2. These results position archvillin as a mechanically sensitive component of the dystrophin complex and demonstrate that signaling defects caused by loss of gamma-SG occur both at the sarcolemma and in the nucleus.
      Title: Gamma-sarcoglycan is required for the response of archvillin to mechanical stimulation in skeletal muscle.
    3. Human genome-wide association and mouse knockout approaches identify platelet supervillin as an inhibitor of thrombus formation under shear stress.
      Title: Human genome-wide association and mouse knockout approaches identify platelet supervillin as an inhibitor of thrombus formation under shear stress.
    4. archvillin is among the first costameric proteins to assemble during myogenesis and that it contributes to myogenic membrane structure and differentiation.
      Title: Archvillin, a muscle-specific isoform of supervillin, is an early expressed component of the costameric membrane skeleton.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4)  1 citation
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables actin filament binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-4,5-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament severing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin polymerization or depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in barbed-end actin filament capping IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within muscle cell differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of cytokinesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in skeletal muscle tissue development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cleavage furrow ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in costamere IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in costamere ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in microtubule minus-end ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in midbody ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in podosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in sarcolemma IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    supervillin
    Names
    archvillin
    p205/p250

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347449.1 → NP_001334378.1  supervillin isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks multiple in-frame exons in the 5' coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
      Source sequence(s)
      AC115928, AC124770, BP761556
      Consensus CDS
      CCDS84352.1
      UniProtKB/TrEMBL
      E3VVQ8
      Conserved Domains (6) summary
      smart00153
      Location:1731 → 1766
      VHP; Villin headpiece domain
      cd11280
      Location:1115 → 1215
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:1431 → 1536
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:994 → 1086
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:1298 → 1411
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:1553 → 1675
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

    2. NM_001405277.1 → NP_001392206.1  supervillin isoform c

      Status: VALIDATED

      Source sequence(s)
      AC115928, AC124770

    3. NM_001405278.1 → NP_001392207.1  supervillin isoform d

      Status: VALIDATED

      Source sequence(s)
      AC115928, AC124770

    4. NM_001405280.1 → NP_001392209.1  supervillin isoform d

      Status: VALIDATED

      Source sequence(s)
      AC115928, AC124770

    5. NM_001405281.1 → NP_001392210.1  supervillin isoform d

      Status: VALIDATED

      Source sequence(s)
      AC115928, AC124770

    6. NM_001405282.1 → NP_001392211.1  supervillin isoform a

      Status: VALIDATED

      Source sequence(s)
      AC115928, AC124770
      UniProtKB/Swiss-Prot
      E9Q983, Q8K4L3
      Related
      ENSMUSP00000119803.2, ENSMUST00000140448.8

    7. NM_001405290.1 → NP_001392219.1  supervillin isoform d

      Status: VALIDATED

      Source sequence(s)
      AC115928, AC124770

    8. NM_153153.4 → NP_694793.1  supervillin isoform a

      See identical proteins and their annotated locations for NP_694793.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AC115928, AC124770
      Consensus CDS
      CCDS37720.1
      UniProtKB/Swiss-Prot
      E9Q983, Q8K4L3
      UniProtKB/TrEMBL
      A0A1B0GS91
      Related
      ENSMUSP00000025079.10, ENSMUST00000025079.16
      Conserved Domains (6) summary
      smart00153
      Location:2135 → 2170
      VHP; Villin headpiece domain
      cd11280
      Location:1519 → 1619
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:1835 → 1940
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:1398 → 1494
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:1702 → 1815
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:1957 → 2079
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      4920497..5119290
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161085.1 → XP_036016978.1  supervillin isoform X12

      UniProtKB/TrEMBL
      Q8K4L2
      Conserved Domains (4) summary
      cd11280
      Location:1536 → 1636
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:1415 → 1507
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:1719 → 1832
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:1852 → 1925
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

    2. XM_006525791.3 → XP_006525854.1  supervillin isoform X1

      See identical proteins and their annotated locations for XP_006525854.1

      UniProtKB/TrEMBL
      A0A1B0GS91
      Conserved Domains (6) summary
      smart00153
      Location:2152 → 2187
      VHP; Villin headpiece domain
      cd11280
      Location:1536 → 1636
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:1852 → 1957
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:1415 → 1511
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:1719 → 1832
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:1974 → 2096
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

    3. XM_030250413.2 → XP_030106273.1  supervillin isoform X13

      UniProtKB/TrEMBL
      E3VVQ8
      Conserved Domains (7) summary
      smart00153
      Location:1834 → 1869
      VHP; Villin headpiece domain
      cd11280
      Location:1218 → 1318
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:1534 → 1639
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:1097 → 1189
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:1401 → 1514
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      PTZ00441
      Location:177 → 335
      PTZ00441; sporozoite surface protein 2 (SSP2); Provisional
      cl15697
      Location:1656 → 1778
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

    4. XM_030250414.2 → XP_030106274.1  supervillin isoform X14

      UniProtKB/TrEMBL
      E3VVQ8
      Conserved Domains (6) summary
      smart00153
      Location:1779 → 1814
      VHP; Villin headpiece domain
      cd11280
      Location:1163 → 1263
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:1479 → 1584
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:1042 → 1138
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:1346 → 1459
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:1601 → 1723
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

    5. XM_036161087.1 → XP_036016980.1  supervillin isoform X17

      UniProtKB/TrEMBL
      E3VVQ8
      Related
      ENSMUSP00000119287.2, ENSMUST00000143254.8
      Conserved Domains (6) summary
      smart00153
      Location:1731 → 1766
      VHP; Villin headpiece domain
      cd11280
      Location:1115 → 1215
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:1431 → 1536
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:994 → 1086
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:1298 → 1411
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:1553 → 1675
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

    6. XM_006525789.3 → XP_006525852.1  supervillin isoform X1

      See identical proteins and their annotated locations for XP_006525852.1

      UniProtKB/TrEMBL
      A0A1B0GS91
      Conserved Domains (6) summary
      smart00153
      Location:2152 → 2187
      VHP; Villin headpiece domain
      cd11280
      Location:1536 → 1636
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:1852 → 1957
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:1415 → 1511
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:1719 → 1832
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:1974 → 2096
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

    7. XM_011246879.3 → XP_011245181.1  supervillin isoform X5

      UniProtKB/TrEMBL
      E9Q3Z5
      Conserved Domains (6) summary
      smart00153
      Location:2120 → 2155
      VHP; Villin headpiece domain
      cd11280
      Location:1504 → 1604
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:1820 → 1925
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:1383 → 1475
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:1687 → 1800
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:1942 → 2064
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

    8. XM_011246876.3 → XP_011245178.1  supervillin isoform X2

      UniProtKB/TrEMBL
      A0A1B0GS91
      Conserved Domains (6) summary
      smart00153
      Location:2151 → 2186
      VHP; Villin headpiece domain
      cd11280
      Location:1535 → 1635
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:1851 → 1956
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:1414 → 1510
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:1718 → 1831
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:1973 → 2095
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

    9. XM_006525792.3 → XP_006525855.1  supervillin isoform X1

      See identical proteins and their annotated locations for XP_006525855.1

      UniProtKB/TrEMBL
      A0A1B0GS91
      Conserved Domains (6) summary
      smart00153
      Location:2152 → 2187
      VHP; Villin headpiece domain
      cd11280
      Location:1536 → 1636
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:1852 → 1957
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:1415 → 1511
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:1719 → 1832
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:1974 → 2096
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

    10. XM_036161071.1 → XP_036016964.1  supervillin isoform X1

      UniProtKB/TrEMBL
      A0A1B0GS91
      Conserved Domains (6) summary
      smart00153
      Location:2152 → 2187
      VHP; Villin headpiece domain
      cd11280
      Location:1536 → 1636
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:1852 → 1957
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:1415 → 1511
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:1719 → 1832
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:1974 → 2096
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

    11. XM_036161078.1 → XP_036016971.1  supervillin isoform X6

      UniProtKB/TrEMBL
      E9Q3Z5
      Conserved Domains (6) summary
      smart00153
      Location:2104 → 2139
      VHP; Villin headpiece domain
      cd11280
      Location:1488 → 1588
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:1804 → 1909
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:1367 → 1459
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:1671 → 1784
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:1926 → 2048
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

    12. XM_011246881.3 → XP_011245183.1  supervillin isoform X8

      UniProtKB/TrEMBL
      E9Q3Z5
      Conserved Domains (6) summary
      smart00153
      Location:2097 → 2132
      VHP; Villin headpiece domain
      cd11280
      Location:1481 → 1581
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:1797 → 1902
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:1360 → 1456
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:1664 → 1777
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:1919 → 2041
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

    13. XM_036161081.1 → XP_036016974.1  supervillin isoform X10

      UniProtKB/TrEMBL
      E9Q3Z5
      Conserved Domains (6) summary
      smart00153
      Location:2081 → 2116
      VHP; Villin headpiece domain
      cd11280
      Location:1465 → 1565
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:1781 → 1886
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:1344 → 1440
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:1648 → 1761
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:1903 → 2025
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

    14. XM_011246878.4 → XP_011245180.1  supervillin isoform X4

      See identical proteins and their annotated locations for XP_011245180.1

      UniProtKB/Swiss-Prot
      E9Q983, Q8K4L3
      UniProtKB/TrEMBL
      A0A1B0GS91
      Related
      ENSMUSP00000115078.2, ENSMUST00000126977.8
      Conserved Domains (6) summary
      smart00153
      Location:2135 → 2170
      VHP; Villin headpiece domain
      cd11280
      Location:1519 → 1619
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:1835 → 1940
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:1398 → 1494
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:1702 → 1815
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:1957 → 2079
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

    15. XM_011246880.3 → XP_011245182.1  supervillin isoform X7

      UniProtKB/TrEMBL
      E9Q3Z5
      Conserved Domains (6) summary
      smart00153
      Location:2103 → 2138
      VHP; Villin headpiece domain
      cd11280
      Location:1487 → 1587
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:1803 → 1908
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:1366 → 1458
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:1670 → 1783
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:1925 → 2047
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

    16. XM_036161083.1 → XP_036016976.1  supervillin isoform X11

      UniProtKB/TrEMBL
      E9Q3Z5
      Conserved Domains (6) summary
      smart00153
      Location:2080 → 2115
      VHP; Villin headpiece domain
      cd11280
      Location:1464 → 1564
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:1780 → 1885
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:1343 → 1439
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:1647 → 1760
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:1902 → 2024
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

    17. XM_011246882.4 → XP_011245184.1  supervillin isoform X13

      UniProtKB/TrEMBL
      E3VVQ8
      Conserved Domains (7) summary
      smart00153
      Location:1834 → 1869
      VHP; Villin headpiece domain
      cd11280
      Location:1218 → 1318
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:1534 → 1639
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:1097 → 1189
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:1401 → 1514
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      PTZ00441
      Location:177 → 335
      PTZ00441; sporozoite surface protein 2 (SSP2); Provisional
      cl15697
      Location:1656 → 1778
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

    18. XM_006525800.5 → XP_006525863.1  supervillin isoform X14

      See identical proteins and their annotated locations for XP_006525863.1

      UniProtKB/TrEMBL
      E3VVQ8
      Conserved Domains (6) summary
      smart00153
      Location:1779 → 1814
      VHP; Villin headpiece domain
      cd11280
      Location:1163 → 1263
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:1479 → 1584
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:1042 → 1138
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:1346 → 1459
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:1601 → 1723
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

    19. XM_017317865.3 → XP_017173354.1  supervillin isoform X15

      UniProtKB/TrEMBL
      E3VVQ8
      Conserved Domains (6) summary
      smart00153
      Location:1763 → 1798
      VHP; Villin headpiece domain
      cd11280
      Location:1147 → 1247
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:1463 → 1568
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:1026 → 1122
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:1330 → 1443
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:1585 → 1707
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

    20. XM_011246884.3 → XP_011245186.1  supervillin isoform X16

      UniProtKB/TrEMBL
      E3VVQ8
      Conserved Domains (6) summary
      smart00153
      Location:1747 → 1782
      VHP; Villin headpiece domain
      cd11280
      Location:1131 → 1231
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:1447 → 1552
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:1010 → 1102
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:1314 → 1427
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:1569 → 1691
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

    21. XM_006525801.5 → XP_006525864.1  supervillin isoform X14

      See identical proteins and their annotated locations for XP_006525864.1

      UniProtKB/TrEMBL
      E3VVQ8
      Conserved Domains (6) summary
      smart00153
      Location:1779 → 1814
      VHP; Villin headpiece domain
      cd11280
      Location:1163 → 1263
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:1479 → 1584
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:1042 → 1138
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:1346 → 1459
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:1601 → 1723
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

    22. XM_030250415.2 → XP_030106275.1  supervillin isoform X17

      UniProtKB/TrEMBL
      E3VVQ8
      Conserved Domains (6) summary
      smart00153
      Location:1731 → 1766
      VHP; Villin headpiece domain
      cd11280
      Location:1115 → 1215
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:1431 → 1536
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:994 → 1086
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:1298 → 1411
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:1553 → 1675
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

    23. XM_036161086.1 → XP_036016979.1  supervillin isoform X14

      UniProtKB/TrEMBL
      E3VVQ8
      Conserved Domains (6) summary
      smart00153
      Location:1779 → 1814
      VHP; Villin headpiece domain
      cd11280
      Location:1163 → 1263
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:1479 → 1584
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:1042 → 1138
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:1346 → 1459
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:1601 → 1723
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

    24. XM_006525790.1 → XP_006525853.1  supervillin isoform X1

      See identical proteins and their annotated locations for XP_006525853.1

      UniProtKB/TrEMBL
      A0A1B0GS91
      Conserved Domains (6) summary
      smart00153
      Location:2152 → 2187
      VHP; Villin headpiece domain
      cd11280
      Location:1536 → 1636
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:1852 → 1957
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:1415 → 1511
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:1719 → 1832
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:1974 → 2096
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

    25. XM_006525793.5 → XP_006525856.1  supervillin isoform X1

      See identical proteins and their annotated locations for XP_006525856.1

      UniProtKB/TrEMBL
      A0A1B0GS91
      Conserved Domains (6) summary
      smart00153
      Location:2152 → 2187
      VHP; Villin headpiece domain
      cd11280
      Location:1536 → 1636
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:1852 → 1957
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:1415 → 1511
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:1719 → 1832
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:1974 → 2096
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

    26. XM_036161077.1 → XP_036016970.1  supervillin isoform X4

      UniProtKB/Swiss-Prot
      E9Q983, Q8K4L3
      UniProtKB/TrEMBL
      A0A1B0GS91
      Conserved Domains (6) summary
      smart00153
      Location:2135 → 2170
      VHP; Villin headpiece domain
      cd11280
      Location:1519 → 1619
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:1835 → 1940
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:1398 → 1494
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:1702 → 1815
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:1957 → 2079
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

    27. XM_036161080.1 → XP_036016973.1  supervillin isoform X9

      UniProtKB/TrEMBL
      E9Q3Z5
      Conserved Domains (6) summary
      smart00153
      Location:2096 → 2131
      VHP; Villin headpiece domain
      cd11280
      Location:1480 → 1580
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:1796 → 1901
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:1359 → 1455
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:1663 → 1776
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:1918 → 2040
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

    28. XM_036161079.1 → XP_036016972.1  supervillin isoform X6

      UniProtKB/TrEMBL
      E9Q3Z5
      Conserved Domains (6) summary
      smart00153
      Location:2104 → 2139
      VHP; Villin headpiece domain
      cd11280
      Location:1488 → 1588
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:1804 → 1909
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:1367 → 1459
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:1671 → 1784
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:1926 → 2048
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

    29. XM_036161082.1 → XP_036016975.1  supervillin isoform X10

      UniProtKB/TrEMBL
      E9Q3Z5
      Conserved Domains (6) summary
      smart00153
      Location:2081 → 2116
      VHP; Villin headpiece domain
      cd11280
      Location:1465 → 1565
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:1781 → 1886
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:1344 → 1440
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:1648 → 1761
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:1903 → 2025
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

    30. XM_036161084.1 → XP_036016977.1  supervillin isoform X11

      UniProtKB/TrEMBL
      E9Q3Z5
      Related
      ENSMUSP00000115223.2, ENSMUST00000127297.8
      Conserved Domains (6) summary
      smart00153
      Location:2080 → 2115
      VHP; Villin headpiece domain
      cd11280
      Location:1464 → 1564
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:1780 → 1885
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:1343 → 1439
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:1647 → 1760
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:1902 → 2024
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_178046.3: Suppressed sequence

      Description
      NM_178046.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K4L3.1 GenPept UniProtKB/Swiss-Prot:Q8K4L3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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