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    Pus7l pseudouridylate synthase 7-like [ Mus musculus (house mouse) ]

    Gene ID: 78895, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Pus7lprovided by MGI
    Official Full Name
    pseudouridylate synthase 7-likeprovided by MGI
    Primary source
    MGI:MGI:1926145
    See related
    Ensembl:ENSMUSG00000033356 AllianceGenome:MGI:1926145
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    3000003F02Rik
    Summary
    Predicted to enable pseudouridine synthase activity. Predicted to be involved in mRNA pseudouridine synthesis. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; forelimb bud; heart ventricle; lower jaw incisor; and lung. Orthologous to human PUS7L (pseudouridine synthase 7 like). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 2.8), CNS E11.5 (RPKM 2.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pus7l in Genome Data Viewer
    Location:
    15 E3; 15 48.52 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (94420521..94441397, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (94522640..94543534, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA D630010B17 gene Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 20 Neighboring gene STARR-seq mESC enhancer starr_39547 Neighboring gene STARR-positive B cell enhancer mm9_chr15:94351032-94351333 Neighboring gene STARR-positive B cell enhancer ABC_E3153 Neighboring gene STARR-seq mESC enhancer starr_39549 Neighboring gene interleukin-1 receptor-associated kinase 4 Neighboring gene STARR-seq mESC enhancer starr_39550 Neighboring gene STARR-positive B cell enhancer ABC_E7408 Neighboring gene twinfilin actin binding protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Lewandowski JP, et al. Dev Biol, 2015 Oct 1. PMID 26238476, Free PMC Article
    2. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article
    3. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
    4. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
    5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pseudouridine synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pseudouridine synthase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables pseudouridine synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA pseudouridine synthesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA pseudouridine synthesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in pseudouridine synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    pseudouridylate synthase PUS7L
    Names
    pseudouridylate synthase 7 homolog-like protein
    NP_766025.1
    XP_006521607.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172437.3 → NP_766025.1  pseudouridylate synthase PUS7L

      See identical proteins and their annotated locations for NP_766025.1

      Status: VALIDATED

      Source sequence(s)
      AK029027, AV296268, BY780892
      Consensus CDS
      CCDS27771.1
      UniProtKB/Swiss-Prot
      Q6NY03, Q8C9X5, Q8CE46
      Related
      ENSMUSP00000044075.4, ENSMUST00000049151.4
      Conserved Domains (3) summary
      cd02576
      Location:302 → 698
      PseudoU_synth_ScPUS7; Pseudouridine synthase, TruD family
      pfam15554
      Location:50 → 170
      FSIP1; FSIP1 family
      cl00130
      Location:22 → 46
      PseudoU_synth; Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      94420521..94441397 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521544.5 → XP_006521607.1  pseudouridylate synthase PUS7L isoform X1

      Conserved Domains (1) summary
      cd02576
      Location:155 → 551
      PseudoU_synth_ScPUS7; Pseudouridine synthase, TruD family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CE46.1 GenPept UniProtKB/Swiss-Prot:Q8CE46

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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