Ust uronyl-2-sulfotransferase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ustprovided by MGI
Official Full Name: uronyl-2-sulfotransferaseprovided by MGI
Primary source: MGI:MGI:2442406
See related: Ensembl:ENSMUSG00000047712 AllianceGenome:MGI:2442406
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: UA2OST; D930010O20Rik
Summary: Predicted to enable sulfotransferase activity. Acts upstream of or within establishment of cell polarity and regulation of axonogenesis. Predicted to be located in Golgi membrane. Is expressed in brain and limb bud. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder. Orthologous to human UST (uronyl 2-sulfotransferase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in cerebellum adult (RPKM 6.7), limb E14.5 (RPKM 2.7) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 A1; 10 2.65 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (8068499..8394701, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (8204753..8518825, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This is the first study showing that Ust, and consequently 2-O sulfation of the low affinity receptor for FgfR CS/DS, reduces Itga5 and leads to an impaired adhesion and migration of melanoma cells
Title: Melanoma Cell Adhesion and Migration Is Modulated by the Uronyl 2-O Sulfotransferase.
analysis of the three CS sulfotransferases in the developing neocortex: uronyl 2-O-sulfotransferase (UST), N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase (4,6-ST) and dermatan 4-O-sulfotransferase-1 (D4-ST)
Title: Oversulfated chondroitin sulfate plays critical roles in the neuronal migration in the cerebral cortex.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Markers

D10Mit76 (e-PCR), detects polymorphism
- UniSTS:126258

Ust (e-PCR), detects polymorphism
- UniSTS:516442

Ust (e-PCR), detects polymorphism
- UniSTS:516443

38.MMHAP53FRE11.seq (e-PCR)
- UniSTS:124284

NoName (e-PCR)
- UniSTS:493307

NoName (e-PCR)
- UniSTS:495103

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3'-phosphoadenosine 5'-phosphosulfate binding	ISS Inferred from Sequence or Structural Similarity more info
enables chondroitin 2-O-sulfotransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables sulfotransferase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within establishment of cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: uronyl 2-sulfotransferase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.